Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Mouse Monoclonal [clone B400] (IgG2b) to Human CD53
Immunoprecipitation, Flow Cytometry
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [B400]
Specificity and Use
CD53 antibody was raised against sezary Syndrome cells.
This antibody reacts with a 33-55kD protein closely related to human CD53 expressed on all leucocytes. Platelets, erythrocytes and non hematopoietic cells do not express this protein. Compatibility: N/A.
50 mM sodium borate, 150 mM sodium chloride, 20% glycerol, 0.05% sodium azide, pH 8.0
CD53 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins.