Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
IHC, Western blot, Immunoprecipitation, Flow Cytometry
Mouse Monoclonal [clone B400] (IgG2b) to Human CD53
Immunoprecipitation, Flow Cytometry
Human (tested or 100% immunogen sequence identity)
IgG2b Monoclonal [B400]
Specificity and Use
CD53 antibody was raised against sezary Syndrome cells.
This antibody reacts with a 33-55kD protein closely related to human CD53 expressed on all leucocytes. Platelets, erythrocytes and non hematopoietic cells do not express this protein. Compatibility: N/A.
50 mM sodium borate, 150 mM sodium chloride, 20% glycerol, 0.05% sodium azide, pH 8.0
CD53 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins.