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Anti-CCND1 / Cyclin D1 Antibody LS-C41861

Ordering

Wt. Vol. Conc. Price
- 100 µl - $635
Inquire for larger quantities

LSBio (Direct) LSBio (Direct)
206-374-1102
866-206-6909
Orders@LSBio.com
 

Most Popular CCND1 / Cyclin D1 Antibodies

Anti-CCND1 / Cyclin D1 Antibody (clone DCS-6, Biotin) LS-C87941
Mouse Monoclonal [clone DCS-6] (IgG2a,k) to Human CCND1 / Cyclin D1
Human, Monkey, Mouse, Rat, Dog
Immunofluorescence, Western blot, Immunoprecipitation, Flow Cytometry, Blocking
Biotin Conjugated

100% Guaranteed 100% Guaranteed
Rabbit Polyclonal (IgG) to Human CCND1 / Cyclin D1
Human, Mouse, Rat
Western blot, ELISA
Unconjugated

Details

Human CCND1 / Cyclin D1
Rabbit
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Dog, Zebrafish, Amphibian (at least 90% immunogen sequence identity)
IgG Polyclonal
Unconjugated
Sterile filtered
Unmodified

Applications

  • Western blot (1:500 - 1:1000)
  • ELISA (1:2000 - 1:10000)

Specificity and Use

CCND1 / Cyclin D1 antibody was raised against gST fusion protein corresponding to the full length human Cyclin D1 amino acid sequence (SwissProt ID: P24385 ).
Cyclin D1, a member of the cyclin family that function as CKD regulators. Cyclin D1 is involved in cell cycle transition and has been shown to interact with the retinoblastoma protein. The unprocessed precursor is 295 amino acids long. It is expressed in abnormally high levels in a number of cancers and is specifically implicated in breast cancer development.
Western Blot: When used on asynchronous HN30 cell lysates, a band was observed at approximately 34 kD corresponding to Cyclin D1.

Packaging

Serum, 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
For research use only.

About CCND1 / Cyclin D1

P24385 NM_053056 NP_444284.1

CCND1 Antibody, B-cell lymphoma 1 protein Antibody, BCL-1 oncogene Antibody, B-cell CLL/lymphoma 1 Antibody, BCL-1 Antibody, Cyclin D1 Antibody, G1/S-specific cyclin-D1 Antibody, U21B31 Antibody, PRAD1 Antibody, BCL1 Antibody, D11S287E Antibody, PRAD1 oncogene Antibody

Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase.

Requested From: United States
Date Requested: 12/6/2016

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