YES1 / c-Yes

v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

YES1 / c-Yes (6)

Publications

No (6)

Tag

GST (1)

GST, N-terminus (1)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

Baculovirus (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human YES1 / c-Yes Protein (Recombinant GST, N-terminus) (aa1-80) - LS-G60535

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human YES1 / c-Yes Protein (Recombinant GST) (Full Length) - LS-G30921

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

85.58 kDa

Price:

2 µg/$439

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Human YES1 / c-Yes Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69874

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.6 kDa

Price:

20 µg/$1,107

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Human YES1 / c-Yes Protein (Recombinant His-GST) (Gly2-Leu543) - LS-G98028

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

88.5 kDa

Price:

50 µg/$707

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Human YES1 / c-Yes Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85735

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.6 kDa

Price:

20 µg/$150

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YES1 / c-Yes Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100548

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

60.6 kDa

Price:

100 µg/$494

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