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YES1 / c-Yes

v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1

Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

Gene Name: v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Family/Subfamily: Protein Kinase , Src
Synonyms: YES1, C-yes, Cyes, Cellular yes-1 protein, HsT441, Oncogene kinase yes1, p61-YES, p61yes, p62c-yes, Proto-oncogene c-Yes, Tyrosine-protein kinase Yes, Yes kinase, v-yes, Yes, Yamaguchi sarcoma oncogene
Target Sequences: NM_005433 NP_005424.1 P07947

Publications (1)

1
Phosphorylation of collapsin response mediator protein 2 on Tyr-479 regulates CXCL12-induced T lymphocyte migration. Varrin-Doyer M, Vincent P, Cavagna S, Auvergnon N, Noraz N, Rogemond V, Honnorat J, Moradi-Amli M, Giraudon P. The Journal of biological chemistry. 2009 284:13265-76. [PubMed:19276087] [PMC:PMC2676058]

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
YES1 / c-Yes (6)
No (6)
GST (1)
GST, N-terminus (1)
His-GST (1)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
Baculovirus (1)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (1)
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Baculovirus
His-GST
Less than 1.0 EU/µg protein (determined by LAL method).
88.5 kDa
50 µg/$707
YES1 / c-Yes Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
60.6 kDa
100 µg/$494
YES1 / c-Yes Protein - Purified recombinant protein YES1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
60.6 kDa
20 µg/$1,107
YES1 / c-Yes Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
60.6 kDa
20 µg/$150
YES1 / c-Yes Protein - 12.5% SDS-PAGE of human YES1 stained with Coomassie Blue
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Wheat Germ Extract
GST
85.58 kDa
2 µg/$439
YES1 / c-Yes Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).