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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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XIAP

X-linked inhibitor of apoptosis

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.

Gene Name: X-linked inhibitor of apoptosis
Family/Subfamily: Apoptosis
Synonyms: XIAP, API3, BIRC4, HILP, IAP-like protein, IAP3, HIAP-3, HIAP3, IAP-3, ILP, ILP1, MIHA, X-linked IAP, XLP2
Target Sequences: NM_001167 NP_001158.2 P98170

Viewing 1-25 of 96 items
XIAP Antibody - Anti-XIAP antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Rabbit Polyclonal to Human XIAP
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
XIAP Antibody - Anti-XIAP antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   1mg/ml   $545.00
XIAP Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl   $425.00
XIAP Antibody - IHC of XIAP in formalin-fixed, paraffin-embedded human breast carcinoma using Polyclonal Antibody to XIAP at 1:2000. A-A3, successively higher magnifications of the breast carcinoma tissue section. Hematoxylin-Eosin counterstain.
Select
Rabbit Polyclonal to Human XIAP
Mouse, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl   $335.00
XIAP Antibody - Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with BIRC4 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
(1) Publication(s)
Rabbit Polyclonal to Human XIAP
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
XIAP Antibody - IHC of XIAP in formalin-fixed, paraffin-embedded human small cell lung carcinoma using Polyclonal Antibody to XIAP at 1:2000. A, low magnification. A1, high magnification. Hematoxylin-Eosin counterstain.
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Rabbit Polyclonal to Human XIAP
Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl   $335.00
XIAP Antibody - Western blot of XIAP using in human embryonic kidney 293 cells using Polyclonal Antibody to XIAP at 1:2000.
Select
Rabbit Polyclonal to Human XIAP
Mouse, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl   $335.00
Select
Rabbit Polyclonal to Human XIAP
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
30µg   $245.00; 100µg   500µl   $385.00
XIAP Antibody - Immunofluorescence analysis of HeLa cells using XIAP antibody. Blue: DAPI for nuclear staining.
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Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Human
IF, WB
Unconjugated
50µl   $235.00; 100µl   $295.00; 200µl   $385.00
XIAP Antibody
Select
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
XIAP Antibody
Select
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
XIAP Antibody - Antibody staining XIAP in human kidney sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH 6). Samples were incubated with primary antibody (1:25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
Select
Mouse Monoclonal [clone 1020CT7.2.2] (IgG1,k) to Human XIAP
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
200µl   $325.00
XIAP Antibody - Immunohistochemistry of paraffin-embedded human rectal cancer using antibody at 1:100 dilution.
Select
Rabbit Polyclonal (IgG) to Human XIAP
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $285.00; 100µl   $385.00
Select
Rabbit Polyclonal (IgG) to Human XIAP
Human
ELISA, IF, IHC, WB
Unconjugated
100µg   $405.00
XIAP Antibody - Immunohistochemistry of paraffin-embedded human kidney tissue.
Select
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µl   $275.00; 100µl   $355.00; 200µl   $455.00
Select
Rabbit Polyclonal (IgG) to Human XIAP
Human
ELISA, ICC, IF, IHC-P
Unconjugated, Preservative Free
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
XIAP Antibody - Western blot analysis of extracts of HeLa cells.
Select
Mouse Monoclonal (IgG) to Human XIAP
Human
IF, IHC, WB
Unconjugated
100µl   $295.00; 200µl   $385.00
Select
Rabbit Polyclonal to Human XIAP
Mouse, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg   $620.00
XIAP Antibody - IHC of XIAP in formalin-fixed, paraffin-embedded human prostate carcinoma using Polyclonal Antibody to XIAP at 1:2000. A, low magnification. A1, high magnification. Hematoxylin-Eosin counterstain.
Select
Rabbit Polyclonal to Human XIAP
Mouse, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl   $335.00
XIAP Antibody - Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using XIAP Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
XIAP Antibody - IHC of XIAP in formalin-fixed, paraffin-embedded human esophageal carcinoma using Polyclonal Antibody to XIAP at 1:2000. Hematoxylin-Eosin counterstain.
Select
Rabbit Polyclonal to Human XIAP
Mouse, Rat, Gerbil, Human
IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µl   $335.00
XIAP Antibody - XIAP antibody. IHC(P): Human Intestinal Cancer Tissue.
Select
Rabbit Polyclonal to Human XIAP
Human
IHC, IHC-P, WB
Unconjugated
100µg   200µl   0.5mg/ml   $355.00
Select
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
XIAP Antibody - Western blot analysis of extracts from 293 cells, using XIAP (Ab-87) antibody.
Select
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µg   $305.00
XIAP Antibody - Western blot of Phospho-XIAP (S87) antibody
Select
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00

Viewing 1-25 of 96 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).