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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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XIAP

X-linked inhibitor of apoptosis

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.

Gene Name: X-linked inhibitor of apoptosis
Family/Subfamily: Apoptosis
Synonyms: XIAP, API3, BIRC4, HILP, IAP-like protein, IAP3, HIAP-3, HIAP3, IAP-3, ILP, ILP1, MIHA, X-linked IAP, XLP2
Target Sequences: NM_001167 NP_001158.2 P98170

Filtered by: None
Target
XIAP (92)
Reactivity
Human (82)
Mouse (47)
Rat (20)
Dog (2)
Gerbil (8)
Pig (8)
Rabbit (2)
Application
IHC (60)
IHC-Fr (6)
IHC-P (18)
WB (84)
ELISA (28)
ICC (7)
IF (8)
IP (12)
Peptide-ELISA (2)
Host
rabbit (80)
mouse (12)
Isotype
IgG (36)
IgG1 (6)
IgG1,k (1)
IgG2a (2)
IgG2a,k (1)
IgG2b (1)
Clonality
monoclonal mc (12)
polyclonal pc (80)
Clone
1020CT7.2.2 (1)
2B3 (1)
2D2-C3-D12 (2)
2F1 (1)
2G1-H10-D9 (2)
5C1-E2-G8-G4-G4 (2)
Format
AP Conjugated (3)
APC (2)
APC Conjugated (3)
Azide-free (7)
Biotin Conjugated (11)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (7)
HRP Conjugated (5)
PE Conjugated (4)
Unconjugated (55)
Epitope
aa1-497 (14)
aa8-219 (10)
aa1-30 (8)
aa163-230 (4)
30-110 aa (2)
C-Terminus (2)
aa359-497 (2)
pSer87 (2)
Gly81 (1)
Internal (1)
aa1-200 (1)
aa14-34 (1)
aa240 (1)
aa241-260 (1)
aa306 (1)
aa53-102 (1)
Publications
No (91)
Yes (1)
Showing 1-25 of 92 results

XIAP Antibody IHC-plus™ LS-B4870
Rabbit Polyclonal to Human XIAP
Human
ICC IF IHC IHC-P WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-XIAP antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Immunofluorescence of methanol-fixed HeLa, using BIRC4 antibody at 1:100 dilution.

XIAP Antibody (aa163-230) LS-C148307
Rabbit Polyclonal to Human XIAP
Mouse, Rat, Gerbil, Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
50µl  $335.00
IHC of XIAP in formalin-fixed, paraffin-embedded human breast carcinoma using Polyclonal Antibody to XIAP at 1:2000. A-A3, successively higher magnifications of the breast carcinoma tissue section. Hematoxylin-Eosin counterstain.
Western blot of XIAP in various tumor cell lines recombinant Polyclonal Antibody to XIAP at 1:2000.

XIAP Antibody (aa1-30) LS-C100373
Publications (1)
Publications (1)
Rabbit Polyclonal to Human XIAP
Mouse, Human
IHC IHC-P WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with BIRC4 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
The anti-BIRC4 antibody is used in Western blot to detect BIRC4 in mouse liver tissue lysate.

XIAP Antibody IHC-plus™ LS-B702
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Human
ELISA IF IHC IHC-P WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-XIAP antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
Anti-XIAP antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.

XIAP Antibody (aa241-260) LS-C148311
Rabbit Polyclonal to Human XIAP
Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
50µl  $335.00
IHC of XIAP in formalin-fixed, paraffin-embedded human small cell lung carcinoma using Polyclonal Antibody to XIAP at 1:2000. A, low magnification. A1, high magnification. Hematoxylin-Eosin counterstain.

XIAP Antibody (aa163-230) LS-C148309
Rabbit Polyclonal to Human XIAP
Mouse, Rat, Gerbil, Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
50µl  $335.00
Western blot of XIAP using in human embryonic kidney 293 cells using Polyclonal Antibody to XIAP at 1:2000.
Western blot of XIAP in various tumor cell lines recombinant Polyclonal Antibody to XIAP at 1:2000.

XIAP Antibody LS-C48229
Rabbit Polyclonal to Human XIAP
Mouse, Rat, Human
IHC IP WB
Unconjugated
30µg  $245.00; 100µg 500µl  $415.00

XIAP Antibody LS-C748335
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Human
IF WB
Unconjugated
50µl  $235.00
Immunofluorescence analysis of HeLa cells using XIAP antibody. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using XIAP antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 10s.

XIAP Antibody (aa1-497) LS-C373001
Rabbit Polyclonal to Human XIAP
Pig, Human
ICC IHC IP WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $305.00; 1ml 0.5mg/ml  $530.00; 10ml 0.5mg/ml  $2,100.00
Immunohistochemistry - Paraffin Image
Immunohistochemistry - Paraffin Image

XIAP Antibody (clone 1020CT7.2.2) LS-C392572
Mouse Monoclonal [clone 1020CT7.2.2] (IgG1,k) to Human XIAP
Human
IF IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl  $215.00; 200µl  $325.00
Antibody staining XIAP in human kidney sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH 6). Samples were incubated with primary antibody (1:25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized HeLa (human cervical epithelial adenocarcinoma cell line) cells labeling Pdx1 with antibody at 1:25 dilution, followed by Dylight 488-conjugated goat anti-mouse IgG secondary antibody at 1:200 dilution (green). Immunofluorescence image showing cytoplasm staining on HeLa cell line. Cytoplasmic actin is detected with Dylight 554 Phalloidin (PD18466410) at 1:100 dilution (red). The nuclear counter stain is DAPI (blue).

XIAP Antibody LS-C393415
Rabbit Polyclonal to Mouse XIAP
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
100µl  $305.00

XIAP Antibody LS-C660647
Rabbit Polyclonal (IgG) to Human XIAP
Human
ELISA IF IHC WB
Unconjugated
100µg  $405.00

XIAP Antibody LS-C346128
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Rat, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunohistochemistry of paraffin-embedded human kidney tissue.
Immunohistochemistry of paraffin-embedded mouse kidney tissue.

XIAP Antibody IHC-plus™ LS-B13363
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
50µl  $425.00
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot analysis of extracts of various cell lines, using XIAP antibody. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.

XIAP Antibody (aa1-200) LS-C377017
Rabbit Polyclonal (IgG) to Human XIAP
Human
ELISA IHC IHC-P WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Immunohistochemistry of paraffin-embedded human rectal cancer using antibody at 1:100 dilution.
Immunohistochemistry of paraffin-embedded human melanoma using antibody at 1:100 dilution.

XIAP Antibody LS-C497979
Mouse Monoclonal (IgG) to Human XIAP
Human
IF IHC WB
Unconjugated
100µl  $295.00; 200µl  $385.00
Western blot analysis of extracts of HeLa cells.

XIAP Antibody (C-Terminus) LS-C18565
Rabbit Polyclonal to Human XIAP
Mouse, Human
IHC IHC-Fr IHC-P WB
Unconjugated
100µg  $605.00

XIAP Antibody (aa163-230) LS-C148310
Rabbit Polyclonal to Human XIAP
Mouse, Rat, Gerbil, Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
50µl  $335.00
IHC of XIAP in formalin-fixed, paraffin-embedded human prostate carcinoma using Polyclonal Antibody to XIAP at 1:2000. A, low magnification. A1, high magnification. Hematoxylin-Eosin counterstain.

XIAP Antibody (aa53-102) LS-C117731
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human skeletal muscle tissue, using XIAP Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from 293 cells, using XIAP Antibody. The lane on the right is blocked with the synthesized peptide.

XIAP Antibody (aa163-230) LS-C148308
Rabbit Polyclonal to Human XIAP
Mouse, Rat, Gerbil, Human
IHC IHC-Fr IHC-P IP WB
Unconjugated
50µl  $335.00
IHC of XIAP in formalin-fixed, paraffin-embedded human esophageal carcinoma using Polyclonal Antibody to XIAP at 1:2000. Hematoxylin-Eosin counterstain.
Western blot of XIAP in various tumor cell lines recombinant Polyclonal Antibody to XIAP at 1:2000.

XIAP Antibody (aa1-30) LS-C329123
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Human
ELISA IHC WB
Unconjugated
200µl  $590.00

XIAP Antibody (30-110 aa) LS-C381277
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of Phospho-XIAP (S87) antibody

XIAP Antibody (30-110 aa) LS-C386686
Rabbit Polyclonal (IgG) to Human XIAP
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of XIAP antibody
Western blot of XIAP antibody

XIAP Antibody LS-C358732
Rabbit Polyclonal to Human XIAP
Mouse, Rat, Gerbil, Human
IHC IP WB
Unconjugated
50µl  $315.00

XIAP Antibody LS-C358733
Rabbit Polyclonal to Human XIAP
Human
IHC IP WB
Unconjugated
50µl  $315.00
Showing 1-25 of 92 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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