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VCAN / Versican

versican

VCAN / Versican is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: versican
Synonyms: VCAN, CSPG2, ERVR, GHAP, Large fibroblast proteoglycan, PG-M, Versican, WGN, Versican core protein, Versican proteoglycan, WGN1
Target Sequences: NM_004385 NP_004376.2 P13611

Publications (4)

1
Repression of versican expression by microRNA-143. Wang X, Hu G, Zhou J. The Journal of biological chemistry. 2010 285:23241-50. (WB; Mouse, Rat) [Full Text Article] [PubMed:20489207] [PMC:PMC2906317] Related Antibodies: LS-C25140.
2
A 3'-untranslated region (3'UTR) induces organ adhesion by regulating miR-199a* functions. Lee DY, Shatseva T, Jeyapalan Z, Du WW, Deng Z, Yang BB. PloS one. 2009 4:e4527. (WB; Mouse) [Full Text Article] [PubMed:19223980] [PMC:PMC2638016] Related Antibodies: LS-C25140.
3
Estradiol induces transcriptional and posttranscriptional modifications in versican expression in the mouse uterus. Salgado RM, Covarrubias AC, Favaro RR, Serrano-Nascimento C, Nunes MT, Zorn TM. Journal of molecular histology. 2013 44:221-9. (IF; Mouse) [Full Text Article] [PubMed:23271141] [PMC:PMC3617353] Related Antibodies: LS-C25140.
4
Inhibitor of DASH proteases affects expression of adhesion molecules in osteoclasts and reduces myeloma growth and bone disease. Pennisi A, Li X, Ling W, Khan S, Gaddy D, Suva LJ, Barlogie B, Shaughnessy JD, Aziz N, Yaccoby S. British journal of haematology. 2009 Jun;145:775-87. [Full Text Article] [PubMed:19388929] [PMC:PMC2748971] Related Antibodies: LS-C37153.
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Products
Proteins (10)
Over-Expression Cell Culture Supernatant (1)
Over-Expression Lysate (1)
Recombinant (8)
VCAN / Versican (10)
No (10)
10His, N-terminus + Myc, C-terminus (1)
10His-B2M, N-terminus + Myc, C-terminus (1)
6His, N-terminus (2)
GST (1)
His, N-Terminal (5)
Human (8)
Mouse (2)
293F Cells (1)
E. coli (5)
HEK 293 Cells (3)
Wheat Germ Extract (1)
Purified (6)
VCAN / Versican Protein - Recombinant Versican By SDS-PAGE
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E. coli
His, N-Terminal
31.7 kDa
10 µg/$282; 50 µg/$450; 100 µg/$717; 200 µg/$897; 1 mg/$2,010; 500 µg/$1,547; 5 mg/$3,137; 2 mg/$2,198
VCAN / Versican Protein
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E. coli
His, N-Terminal
31.1 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
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HEK 293 Cells
6His, N-terminus
39 kDa
100 µg/$298
VCAN / Versican Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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HEK 293 Cells
His, N-Terminal
39.2 kDa
10 µg/$289; 50 µg/$360; 200 µg/$646
VCAN / Versican Protein - Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of Recombinant Mouse Versican core protein(Vcan),partial could indicate that this peptide derived from E.coli-expressed Mus musculus (Mouse) Vcan.
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E. coli
10His, N-terminus + Myc, C-terminus
20.9 kDa
20 µg/$405; 1 mg/$1,679; 100 µg/$598
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293F Cells
His, N-Terminal
50kDa
10 µg/$275; 50 µg/$402; 200 µg/$802; 100 µg/$642; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
VCAN / Versican Protein - 12.5% SDS-PAGE of human CSPG2 stained with Coomassie Blue
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Wheat Germ Extract
GST
65.7 kDa
2 µg/$439
VCAN / Versican Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His-B2M, N-terminus + Myc, C-terminus
1 mg/$1,486; 100 µg/$451; 20 µg/$339
VCAN / Versican Protein
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E. coli
His, N-Terminal
43 kDa
10 µg/$265; 100 µg/$365; 50 µg/$315
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HEK 293 Cells
6His, N-terminus
39 kDa
200 µl/$283
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).