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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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UBC / Ubiquitin C

ubiquitin C

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Gene Name: ubiquitin C
Synonyms: UBC, HUBCEP52, L40, HMG20, RPL40, Ubiquitin, Polyubiquitin-C, CEP52, Ubiquitin C
Target Sequences: M26880 AAA36789.1 P0CG48

Publications (5)

1
Induction of inclusion formation and disruption of lamin A/C structure by premutation CGG-repeat RNA in human cultured neural cells. Arocena DG, Iwahashi CK, Won N, Beilina A, Ludwig AL, Tassone F, Schwartz PH, Hagerman PJ. Human molecular genetics. 2005 14:3661-71. [PubMed:16239243]
2
Protein composition of the intranuclear inclusions of FXTAS. Iwahashi CK, Yasui DH, An HJ, Greco CM, Tassone F, Nannen K, Babineau B, Lebrilla CB, Hagerman RJ, Hagerman PJ. Brain : a journal of neurology. 2006 129:256-71. [PubMed:16246864]
3
Regulation of phosphoglucose isomerase/autocrine motility factor activities by the poly(ADP-ribose) polymerase family-14. Yanagawa T, Funasaka T, Tsutsumi S, Hu H, Watanabe H, Raz A. Cancer research. 2007 67:8682-9. [PubMed:17875708]
4
CGG-repeat length threshold for FMR1 RNA pathogenesis in a cellular model for FXTAS. Hoem G, Raske CR, Garcia-Arocena D, Tassone F, Sanchez E, Ludwig AL, Iwahashi CK, Kumar M, Yang JE, Hagerman PJ. Human molecular genetics. 2011 20:2161-70. [PubMed:21389081] [PMC:PMC3090194]
5
Protein aggregates are recruited to aggresome by histone deacetylase 6 via unanchored ubiquitin C termini. Ouyang H, Ali YO, Ravichandran M, Dong A, Qiu W, MacKenzie F, Dhe-Paganon S, Arrowsmith CH, Zhai RG. The Journal of biological chemistry. 2012 287:2317-27. [PubMed:22069321] [PMC:PMC3268394] Related Antibodies: LS-B3386.
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Filtered by: None
Target
UBC / Ubiquitin C (9)
Reactivity
Human (9)
Mouse (5)
Rat (5)
Bovine (3)
C. elegans (1)
Chicken (1)
Drosophila (1)
Pig (1)
Application
IHC (7)
IHC-P (4)
WB (9)
ELISA (2)
IF (5)
Host
rabbit (7)
mouse (2)
Isotype
IgG (2)
IgG2a (2)
Clonality
monoclonal mc (2)
polyclonal pc (7)
Clone
5B9.B3 (1)
Format
Unconjugated (9)
Epitope
aa1-32 (1)
aa36-66 (1)
Publications
No (8)
Yes (1)
Showing 1-9 of 9 results

IHC-plus™ UBC / Ubiquitin C Antibody (aa1-32) LS-B3386
Publications (1)
Publications (1)
Rabbit Polyclonal to Human UBC / Ubiquitin C
Human
IHC, IHC-P, WB
Unconjugated
200µl  $425.00
Anti-UBC / Ubiquitin C antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot of anti-Ubiquitin antibody in HeLa cell lysate. Ubiquitin (Arrow) was detected using purified antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.

IHC-plus™ UBC / Ubiquitin C Antibody (aa36-66) LS-B3621
Rabbit Polyclonal to Human UBC / Ubiquitin C
Human
IF, IHC, IHC-P, WB
Unconjugated
200µl  $425.00
Anti-UBC / Ubiquitin C antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-UBC / Ubiquitin C antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

UBC / Ubiquitin C Antibody LS-C2924
Rabbit Polyclonal to Human UBC / Ubiquitin C
Chicken, Drosophila, Bovine, Mouse, Rat, Human, C. elegans
IF, IHC, WB
Unconjugated
50µl  $335.00
Immunofluorescent staining of aggresomes of mouse L-cells treated with lactacysteine.

UBC / Ubiquitin C Antibody LS-C393210
Rabbit Polyclonal to Human UBC / Ubiquitin C
Mouse, Rat, Pig, Human
IF, IHC, IHC-P, WB
Unconjugated
100µl  $325.00

UBC / Ubiquitin C Antibody LS-C755367
Rabbit Polyclonal (IgG) to Human UBC / Ubiquitin C
Human
ELISA, IHC, WB
Unconjugated
100µg  $355.00

UBC / Ubiquitin C Antibody (clone 5B9.B3) LS-C760046
Mouse Monoclonal [clone 5B9.B3] (IgG2a) to Bovine UBC / Ubiquitin C
Mouse, Bovine, Rat, Human
ELISA, IF, WB
Unconjugated
100µg  $375.00
2% formaldehyde-fixed HeLa cells, 100X magnification.
(1) HeLa whole cell lysate, (2) Jurkat whole cell lysate.

UBC / Ubiquitin C Antibody LS-C667678
Rabbit Polyclonal to Human UBC / Ubiquitin C
Human
IHC, IHC-P, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $275.00
Immunohistochemistry - Paraffin Image
Western blot Image

UBC / Ubiquitin C Antibody LS-C771557
Rabbit Polyclonal (IgG) to Human UBC / Ubiquitin C
Mouse, Rat, Human
IHC, WB
Unconjugated
60µl 1mg/ml  $235.00; 120µl 1mg/ml  $295.00; 200µl 1mg/ml  $395.00

UBC / Ubiquitin C Antibody LS-C760045
Mouse Monoclonal (IgG2a) to Bovine UBC / Ubiquitin C
Mouse, Bovine, Rat, Human
IF, WB
Unconjugated
100µg  $375.00
2% formaldehyde-fixed HeLa cells, 100X magnification
HeLa whole cell lysate
Showing 1-9 of 9 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).