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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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TNFSF9 / CD137L

tumor necrosis factor (ligand) superfamily, member 9

TNFSF9 / CD137L is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

Gene Name: tumor necrosis factor (ligand) superfamily, member 9
Family/Subfamily: TNF , not assigned-TNF
Synonyms: TNFSF9, 4-1BBL, 4-1BB ligand, 4-1BB-L, CD137L, Homolog of mouse 4-1BB-L, Receptor 4-1BB ligand
Target Sequences: NM_003811 NP_003802.1 P41273

Publications (2)

1
Induction of proliferation and monocytic differentiation of human CD34+ cells by CD137 ligand signaling. Jiang D, Yue PS, Drenkard D, Schwarz H. Stem cells (Dayton, Ohio). 2008 26:2372-81. [PubMed:18566330] Related Antibodies: LS-C41003.
2
Expression of CD137 on Hodgkin and Reed-Sternberg cells inhibits T-cell activation by eliminating CD137 ligand expression. Ho WT, Pang WL, Chong SM, Castella A, Al-Salam S, Tan TE, Moh MC, Koh LK, Gan SU, Cheng CK, Schwarz H. Cancer research. 2013 73:652-61. [PubMed:23204227] Related Antibodies: LS-C41003.

Viewing 1-25 of 68 items
TNFSF9 / CD137L Antibody - Anti-4-1BBL / CD137L antibody IHC of human kidney, glomeruli. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $425.00
TNFSF9 / CD137L Antibody - Anti-TNFSF9 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $425.00
TNFSF9 / CD137L Antibody - Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human TNFSF9 / CD137L
Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   $485.00
TNFSF9 / CD137L Antibody - Western blot analysis of human CD137L using anti-CD137L (human), mAb (41B436) at 1:2,000dilution. 1: Recombinant humanCD137L (FLAG-tagged). 2: Recombinant mouse CD137L (FLAG-tagged).
Select
Mouse Monoclonal [clone 41B436] (IgG1,k) to Human TNFSF9 / CD137L
Human
ELISA, Flo, ICC, WB
Unconjugated
50µg   $295.00; 100µg   1mg/ml   $345.00
Select
Mouse Monoclonal [clone 5F4] (IgG1,k) to Human TNFSF9 / CD137L
Human
Flo
FITC Conjugated
1000µl   0.05mg/ml   $335.00
TNFSF9 / CD137L Antibody - HuT 78 (T lymphoma cell line) stained with purified 5F4, then detected with biotinylated antimouse IgG followed by Sav-PE.
Select
Mouse Monoclonal [clone 5F4] (IgG1) to Human TNFSF9 / CD137L
Human
Flo
Unconjugated
100µg   0.5mg/ml   $235.00
Select
Rat Monoclonal [clone AT113-2] (IgG1) to Mouse TNFSF9 / CD137L
Mouse
Flo, IP
Unconjugated
0.25mg   $395.00
TNFSF9 / CD137L Antibody - Western blot analysis of CD137L expression in HeLa (A); SP2/0 (B); H9C2 (C); rat liver (D) whole cell lysates.
Select
Rabbit Polyclonal to Human TNFSF9 / CD137L
Mouse, Rat, Human
WB
Unconjugated
100µl   1mg/ml   $245.00
Select
Rat Monoclonal (IgG2b) to Mouse TNFSF9 / CD137L
Mouse
ELISA, Flo, WB
Unconjugated
500µg   $815.00
TNFSF9 / CD137L Antibody - Flow cytometry of TNFSF9 / CD137L antibody
Select
Mouse Monoclonal [clone ANC5D6] (IgG2a,k) to Human TNFSF9 / CD137L
Human
ELISA, Flo, WB
Unconjugated
100µg   1mg/ml   $345.00
TNFSF9 / CD137L Antibody - Flow cytometry of TNFSF9 / CD137L antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone ANC5D6] (IgG2a,k) to Human TNFSF9 / CD137L
Human
ELISA, Flo, Func, WB
Biotin Conjugated
100µg   1mg/ml   $435.00
TNFSF9 / CD137L Antibody - Flow cytometry of TNFSF9 / CD137L antibody This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone ANC5D6] (IgG2a,k) to Human TNFSF9 / CD137L
Human
ELISA, Flo, WB
RPE Conjugated
120tst   $465.00
TNFSF9 / CD137L Antibody - Flow cytometry of TNFSF9 / CD137L antibody This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
Mouse Monoclonal [clone ANC5D6] (IgG2a,k) to Human TNFSF9 / CD137L
Human
ELISA, Flo, WB
Unconjugated, Azide-free
100µg   1mg/ml   $345.00
Select
Mouse Monoclonal [clone ANC5D6] (IgG2a,k) to Human TNFSF9 / CD137L
Human
ELISA, Flo, WB
Biotin Conjugated
100µg   $635.00
TNFSF9 / CD137L Antibody - Immunohistochemistry of paraffin-embedded human placenta tissue using TNFSF9 Antibody at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IHC, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IHC, WB
HRP Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IHC, WB
Biotin Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IHC, WB
FITC Conjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal to Mouse TNFSF9 / CD137L
Mouse
ELISA, Flo, ICC, IF
Unconjugated
50µl   $245.00; 100µl   $305.00
TNFSF9 / CD137L Antibody - Western blot analysis of extracts of various cell lines, using TNFSF9 antibody at 1:1000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 10s.
Select
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Mouse, Human
WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $295.00; 200µl   $385.00
Select
Mouse Monoclonal (IgG2b) to Human TNFSF9 / CD137L
Human
ELISA, Flo, WB
Unconjugated
100µg   $650.00
Select
Mouse Monoclonal (IgG2b) to Human TNFSF9 / CD137L
Human
ELISA, Flo, WB
Unconjugated
100µg   $680.00; 500µg   $1,410.00
TNFSF9 / CD137L Antibody - Western blot of CD137L antibody
Select
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IF, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
TNFSF9 / CD137L Antibody - Staining HuvEc cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
Select
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
TNFSF9 / CD137L Antibody - Immunofluorescence analysis of HeLa cells, using TNFSF9 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human TNFSF9 / CD137L
Human
IF, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00

Viewing 1-25 of 68 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).