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TNFRSF1B / TNFR2

tumor necrosis factor receptor superfamily, member 1B

Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.

Gene Name: tumor necrosis factor receptor superfamily, member 1B
Family/Subfamily: TNF Receptor , not assigned-TNF Receptor
Synonyms: TNFRSF1B, CD120b antigen, CD120b, p75 TNF receptor, Soluble TNFR1B variant 1, TNFBR, Tumor necrosis factor receptor, TNF-R-II, TNF-R75, TNFR2, p75TNFR, p80 TNF-alpha receptor, TBPII, TNF-R2, TNFR80, TNF-RII, TNFR-II, TNFR1B
Target Sequences: NM_001066 NP_001057.1 P20333

Publications (1)

1
Selective inhibition of soluble tumor necrosis factor signaling reduces abdominal aortic aneurysm progression. Silke Griepke, Emilie Grupe, Jes Sanddal Lindholt, Elizabeth Hvitfeldt Fuglsang, Lasse Bach Steffensen, Hans Christian Beck, Mia Dupont Larsen, Sissel Karoline Bang-Møller, Martin Overgaard, Lars Melholt Rasmussen, Kate Lykke Lambertsen, Jane Stubbe. Frontiers in cardiovascular medicine. 2022 October;9:942342. [Full Text Article] [PubMed:36186984] [PMC:PMC9523116]

☰ Filters
Products
Proteins (31)
Over-Expression Lysate (2)
Recombinant (29)
TNFRSF1B / TNFR2 (31)
No (31)
6His, C-terminus (7)
AVI-6His, C-terminus (1)
Fc (1)
Fc, C-terminus (4)
GST (2)
His (2)
His, N-Terminal (1)
His,C-terminus (3)
His-Fc (1)
His-GST (1)
mFc, C-terminus (1)
Myc-DDK (Flag) (2)
Human (20)
Mouse (7)
Rat (1)
Rhesus monkey (2)
293T Cells (1)
E. coli (8)
HEK 293 Cells (3)
Human (4)
Human Cells (7)
Mammalian Cells (6)
Wheat Germ Extract (1)
Purified (6)
Low endotoxin level (22)
Biologically active (6)
TNFRSF1B / TNFR2 Protein - Recombinant  Tumor Necrosis Factor Receptor Superfamily, Member 1B By SDS-PAGE
Select
E. coli
His, N-Terminal
25.8 kDa
10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231
TNFRSF1B / TNFR2 Protein
Select
E. coli
None
Biologically active
20.0 kDa
5 µg/$282; 100 µg/$957; 500 µg/$1,747
Select
Human Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
51.9kD
10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157
TNFRSF1B / TNFR2 Protein - Recombinant Tumor Necrosis Factor Receptor Superfamily, Member 1B By SDS-PAGE
Select
E. coli
His
19.4 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
26.7 kDa
100 µg/$721
TNFRSF1B / TNFR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
48.29 kDa
20 µg/$150
TNFRSF1B / TNFR2 Protein - Recombinant Mouse TNF Receptor II/TNF RII/TNFRSF1B/CD120b (C-6His-Avi) Biotinylated
Select
Human
AVI-6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
28.2 kDa
20 µg/$416; 100 µg/$910
TNFRSF1B / TNFR2 Protein - Recombinant Mouse TNF Receptor II/TNF RII/TNFRSF1B/CD120b (C-Fc)
Select
Human
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52.3 kDa
10 µg/$317; 50 µg/$529
TNFRSF1B / TNFR2 Protein - Recombinant Rhesus Macaque TNF Receptor II/TNF RII/TNFRSF1B/CD120b (C-Fc)
Select
Human
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
52 kDa
10 µg/$322; 50 µg/$546
TNFRSF1B / TNFR2 Protein - Recombinant Rhesus Macaque TNF Receptor II/TNF RII/TNFRSF1B/CD120b (C-6His)
Select
Human
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
25.9 kDa
10 µg/$319; 50 µg/$535
TNFRSF1B / TNFR2 Protein - 12.5% SDS-PAGE of human TNFRSF1B stained with Coomassie Blue
Select
Wheat Germ Extract
GST
74.03 kDa
10 µg/$479; 25 µg/$670
TNFRSF1B / TNFR2 Protein - Recombinant  Tumor Necrosis Factor Receptor Superfamily, Member 1B By SDS-PAGE
Select
E. coli
His-GST
44.8 kDa
10 µg/$272; 50 µg/$387; 100 µg/$620; 200 µg/$772; 1 mg/$1,834; 500 µg/$1,393; 5 mg/$2,794; 2 mg/$2,016
TNFRSF1B / TNFR2 Protein
Select
E. coli
GST
46.65 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Select
None
Biologically active
18.9 kD
20 µg/$476
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
26.8 kDa
100 µg/$721
TNFRSF1B / TNFR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
48.29 kDa
100 µg/$494
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
18.9 kDa
5 µg/$268; 20 µg/$349
TNFRSF1B / TNFR2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
26.2 kDa
50 µg/$516; 10 µg/$313; 1 mg/$2,837; 500 µg/$1,987
Select
HEK 293 Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
27.7 kDa
100 µg/$721
Select
Mammalian Cells
Fc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
51.9 kDa
10 µg/$281; 50 µg/$389
TNFRSF1B / TNFR2 Protein - Inhibition of TNFα-induced cytotoxicity in L929 cells by soluble TNF-RII.
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg (determined by LAL method).
The 184 amino acid recombinant protein has a predicted molecular mass of approximately 20 kD. The DTT-reduced protein migrates at approximately 21 kD and the non-reduced protein migrates at approximately 19 kD by SDS-PAGE. The N-terminal amino acid is Met
10 µg/$306; 25 µg/$375; 100 µg/$731
Select
Mammalian Cells
His,C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
26.2 kDa
10 µg/$288; 50 µg/$436
Select
Mammalian Cells
mFc, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.44 kDa
10 µg/$288; 50 µg/$436
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
26.4 kDa
10 µg/$281; 50 µg/$389
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
19.0 kDa
10 µg/$288; 50 µg/$436
Viewing 1-25 of 31 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).