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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TLK1

tousled-like kinase 1

Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'.

Gene Name: tousled-like kinase 1
Family/Subfamily: Protein Kinase , TLK
Synonyms: TLK1, KIAA0137, Tousled-like kinase 1, Snare kinase snak, PKU-beta, SNARE protein kinase SNAK
Target Sequences: NM_012290 NP_036422.3 Q9UKI8

Filtered By: None
Target
TLK1 (41)
Reactivity
Human (33)
Mouse (22)
Rat (13)
Bat (4)
Bovine (9)
Chicken (1)
Chimpanzee (6)
Dog (11)
Gibbon (6)
Guinea pig (4)
Hamster (4)
Horse (10)
Monkey (10)
Orangutan (6)
Pig (9)
Rabbit (10)
Zebrafish (8)
Application
IHC (11)
IHC-P (3)
WB (39)
ELISA (19)
IF (2)
IP (2)
Peptide-ELISA (2)
PLA (1)
Host
rabbit (40)
mouse (1)
Isotype
IgG (23)
IgG3,k (1)
Clonality
monoclonal mc (1)
polyclonal pc (40)
Clone
4B3 (1)
Format
AP Conjugated (2)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (2)
Unconjugated (23)
Epitope
aa701-728 (8)
aa720-750 (8)
aa108-157 (4)
aa251-300 (4)
Internal (2)
pSer743 (2)
180-260 aa, Internal (1)
680-760 aa (1)
aa150-200 (1)
aa201-250 (1)
aa716-766 (1)
aa730-779 (1)
aa737-751 (1)
Publications
No (41)
Showing 1-25 of 41 results

TLK1 Antibody (aa730-779) IHC-plus™ LS-B9860
Rabbit Polyclonal (IgG) to Human TLK1
Mouse, Human
IF IHC IHC-P Peptide-ELISA
Unconjugated
50µl 1mg/ml  $425.00
Anti-TLK1 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Immunofluorescence analysis of COS7 cells, using TLK1 Antibody. The picture on the right is blocked with the synthesized peptide.
Anti-TLK1 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Immunofluorescence analysis of COS7 cells, using TLK1 Antibody. The picture on the right is blocked with the synthesized peptide.

TLK1 Antibody (clone 4B3) LS-C133607
Mouse Monoclonal [clone 4B3] (IgG3,k) to Human TLK1
Human
ELISA IHC IHC-P WB
Unconjugated
100µg  $355.00
Immunoperoxidase of monoclonal antibody to TLK1 on formalin-fixed paraffin-embedded human testis. [antibody concentration 1 ug/ml]
TLK1 monoclonal antibody (M01), clone 4B3 Western blot of TLK1 expression in HeLa NE.
Immunoperoxidase of monoclonal antibody to TLK1 on formalin-fixed paraffin-embedded human testis. [antibody concentration 1 ug/ml]
TLK1 monoclonal antibody (M01), clone 4B3 Western blot of TLK1 expression in HeLa NE.

TLK1 Antibody (aa720-750) LS-C328901
Rabbit Polyclonal (IgG) to Human TLK1
Human
ELISA IHC WB
Unconjugated
200µl  $530.00

TLK1 Antibody (aa720-750, Biotin) LS-C283632
Rabbit Polyclonal (IgG) to Human TLK1
Human
ELISA IHC WB
Biotin Conjugated
200µl  $680.00

TLK1 Antibody (aa720-750, FITC) LS-C283633
Rabbit Polyclonal (IgG) to Human TLK1
Human
ELISA IHC WB
FITC Conjugated
200µl  $680.00

TLK1 Antibody (aa720-750, AP) LS-C283630
Rabbit Polyclonal (IgG) to Human TLK1
Human
ELISA IHC WB
AP Conjugated
200µl  $680.00

TLK1 Antibody (aa720-750, APC) LS-C283631
Rabbit Polyclonal (IgG) to Human TLK1
Human
ELISA IHC WB
APC Conjugated
200µl  $680.00

TLK1 Antibody (aa720-750, Azide-free, HRP) LS-C283634
Rabbit Polyclonal (IgG) to Human TLK1
Human
ELISA IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

TLK1 Antibody (aa720-750, PE) LS-C283636
Rabbit Polyclonal (IgG) to Human TLK1
Human
ELISA IHC WB
PE Conjugated
200µl  $680.00

TLK1 Antibody (aa720-750) LS-C101204
Rabbit Polyclonal to Human TLK1
Human
IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of hTLK1-L687 in K562 cell line lysates (35 ug/lane). TLK1 (arrow) was detected using the purified antibody.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Western blot of hTLK1-L687 in K562 cell line lysates (35 ug/lane). TLK1 (arrow) was detected using the purified antibody.

TLK1 Antibody (680-760 aa) LS-C386436
Rabbit Polyclonal (IgG) to Human TLK1
Mouse, Human
ELISA IF
Unconjugated
100µl 1mg/ml  $265.00

TLK1 Antibody (aa701-728) LS-C325749
Rabbit Polyclonal (IgG) to Mouse TLK1
Mouse
ELISA WB
Unconjugated
200µl  $530.00

TLK1 Antibody (aa701-728, Biotin) LS-C271586
Rabbit Polyclonal (IgG) to Mouse TLK1
Mouse
ELISA WB
Biotin Conjugated
200µl  $680.00

TLK1 Antibody (aa701-728, FITC) LS-C271587
Rabbit Polyclonal (IgG) to Mouse TLK1
Mouse
ELISA WB
FITC Conjugated
200µl  $680.00

TLK1 Antibody (aa701-728, APC) LS-C271585
Rabbit Polyclonal (IgG) to Mouse TLK1
Mouse
ELISA WB
APC Conjugated
200µl  $680.00

TLK1 Antibody (aa701-728, PE) LS-C271589
Rabbit Polyclonal (IgG) to Mouse TLK1
Mouse
ELISA WB
PE Conjugated
200µl  $680.00

TLK1 Antibody (aa701-728, Azide-free, HRP) LS-C271588
Rabbit Polyclonal (IgG) to Mouse TLK1
Mouse
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

TLK1 Antibody (aa701-728, AP) LS-C271584
Rabbit Polyclonal (IgG) to Mouse TLK1
Mouse
ELISA WB
AP Conjugated
200µl  $680.00

TLK1 Antibody LS-C410446
Rabbit Polyclonal (IgG) to Human TLK1
Human
IHC WB
Unconjugated
100µl  $295.00; 200µl  $385.00

TLK1 Antibody (aa150-200) LS-C288066
Rabbit Polyclonal (IgG) to Human TLK1
Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Horse, Human
IP PLA WB
Unconjugated
100µl 0.2mg/ml  $395.00

TLK1 Antibody LS-C661054
Rabbit Polyclonal (IgG) to Human TLK1
Human
ELISA WB
Unconjugated
100µg  $435.00

TLK1 Antibody (aa737-751) LS-C18924
Rabbit Polyclonal to Human TLK1
Dog, Human
ELISA WB
Unconjugated
100µg  $425.00
Anti-Tlk-1 Antibody - Western Blot. Western blot of Affinity Purified anti-Tlk-1 antibody shows detection of a band ~64 kD corresponding to isoform 3 of human Tlk-1 (arrowhead). Specific reactivity with this band is blocked when the antibody is pre-incubated with the immunizing peptide (data not shown). Approximately 30 ug of a HeLa nuclear extract was separated by SDS-PAGE and transferred onto nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:250 for 2h at room temperature followed by washes and reaction with a 1:10000 dilution of IRDye 800 conjugated Gt-a-Rabbit IgG [H&L] MX ( for 45 min at room temperature. IRDye800 fluorescence image was captured using the Odyssey Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results.
Anti-Tlk-1 Antibody - Western Blot. Western blot of Affinity Purified anti-Tlk-1 antibody shows detection of a band ~64 kD corresponding to isoform 3 of human Tlk-1 (arrowhead). Specific reactivity with this band is blocked when the antibody is pre-incubated with the immunizing peptide (data not shown). Approximately 30 ug of a HeLa nuclear extract was separated by SDS-PAGE and transferred onto nitrocellulose. After blocking the membrane was probed with the primary antibody diluted to 1:250 for 2h at room temperature followed by washes and reaction with a 1:10000 dilution of IRDye 800 conjugated Gt-a-Rabbit IgG [H&L] MX ( for 45 min at room temperature. IRDye800 fluorescence image was captured using the Odyssey Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results.

TLK1 Antibody (180-260 aa, Internal) LS-C386437
Rabbit Polyclonal (IgG) to Human TLK1
Human
ELISA WB
Unconjugated
100µl 1mg/ml  $265.00
Western blot of TLK1 antibody
Western blot of TLK1 antibody

TLK1 Antibody (aa716-766) LS-C288067
Rabbit Polyclonal (IgG) to Human TLK1
Rabbit, Mouse, Dog, Rat, Pig, Horse, Human
IP WB
Unconjugated
100µl 0.2mg/ml  $395.00

TLK1 Antibody (aa201-250) LS-C291452
Rabbit Polyclonal (IgG) to Human TLK1
Human
Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Showing 1-25 of 41 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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