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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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THRA / THR Alpha

Thyroid Hormone Receptor, Alpha

Thyroid hormone receptor alpha (TR alpha), a NR1 Thyroid Hormone-Like Receptor, mediates the diverse actions of thyroid hormone in development, differentiation, and metabolism. Four protein isoforms are encoded by the same TR alpha genomic locus: TR alpha1 (410 aa) (Nakai et al. 1988), TR alpha2 (490 aa) ( Nakai et al. 1988), TR deltaalpha1 (~154 aa), and TR deltaalpha2 (~237 aa); however, only TR alpha1 is able to bind the ligand ( Lazar et al. 1988). TR alpha1 and TR alpha2 are products of alternative splicing of the primary TR alpha mRNA, whereas TR deltaalpha1 and TR deltaalpha2 arise from transcription of an internal promoter in intron 7 of the TR alpha gene. A truncated form of TR alpha, called p43 for 43-kD, has been shown to regulate mitochondrial transcription Casas et al. 2003. Mice lacking all forms of TR alpha have been shown to be viable, but show reduced linear growth, delayed bone maturation, increased hypothermia, reduced thickness of the intestinal mucosa, lowered heart rates, and lowered serum T4. TR alpha has been linked to chronic fatigue Englebienne et al. 2003.

Gene Name: Thyroid Hormone Receptor, Alpha
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: THRA, AR7, C-ERBA-1, C-erbaalpha, EAR-7.1/EAR-7.2, ERB-T-1, ERBA1, EAR-7, ERBA-related 7, HTR alpha 1, HTR alpha 2, THRA1, Thyroid hormone receptor alpha, T3R, Tralpha2, Triiodothyronine receptor, V-erbA-related protein 7, Thyroid hormone receptor, Tralpha1, NR1A1, THRA3, C-erbA-alpha, CHNG6, EAR7, ERBA, Erba-alpha, THRA2, TR alpha, Tralpha
Target Sequences: NM_003250 NP_003241.2 P10827

Viewing 1-25 of 64 items
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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Goat Polyclonal to Human THRA / THR Alpha
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
THRA / THR Alpha Antibody - Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
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Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
THRA / THR Alpha Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
THRA / THR Alpha Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50µg   $285.00; 100µg   $385.00
THRA / THR Alpha Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50µg   $285.00; 100µg   $385.00
THRA / THR Alpha Antibody - Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50µg   $285.00; 100µg   $385.00
THRA / THR Alpha Antibody - Anti-THRA Antibody - Western Blot. Western blot of affinity purified anti-THRA antibody shows detection of purified recombinant THRA (lane 1) and THRA present in a 293 cell lysate after transient transfection with THRA (lane 3). No staining is evident in lysates from mock-transfected 293 cells (lane 2). Endogenous THRA is not detected in mouse brain whole cell lysate (lane 4). Nuclear extracts may be required to detect endogenous THRA as the protein localizes within the nucleus. The band at ~55 kD, indicated by the arrowhead, corresponds to THRA. Personal communication, S. Cheng and H. Ying, NCI, Bethesda, MD.
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Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg   1mg/ml   $425.00
THRA / THR Alpha Antibody - Western blot using the affinity purified anti-THRA antibody shows detection of purified recombinant THRA (lane 1) and THRA present in a 293 cell lysate after transient transfection with THRA (lane 3). No staining is evident in lysates from mock-transfected 293 cells (lane 2). Endogenous THRA is not detected in mouse brain whole cell lysate (lane 4). Nuclear extracts may be required to detect endogenous THRA as the protein localizes within the nucleus. The band at ~55 kDa, indicated by the arrowhead, corresponds to THRA.
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Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Human
ELISA, IF, IHC, IP, WB
Unconjugated
25µl   0.89mg/ml   $235.00
THRA / THR Alpha Antibody - THRA antibody Western blot of Rat Muscle lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Rat THRA / THR Alpha
Zebrafish, Pig, Horse, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
THRA / THR Alpha Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-THRA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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Mouse Monoclonal [clone OTI2A2] (IgG1) to Human THRA / THR Alpha
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
THRA / THR Alpha Antibody - Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-THRA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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Mouse Monoclonal [clone OTI2A2] (IgG1) to Human THRA / THR Alpha
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00

Viewing 1-25 of 64 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).