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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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THRA / THR Alpha

Thyroid Hormone Receptor, Alpha

Thyroid hormone receptor alpha (TR alpha), a NR1 Thyroid Hormone-Like Receptor, mediates the diverse actions of thyroid hormone in development, differentiation, and metabolism. Four protein isoforms are encoded by the same TR alpha genomic locus: TR alpha1 (410 aa) (Nakai et al. 1988), TR alpha2 (490 aa) ( Nakai et al. 1988), TR deltaalpha1 (~154 aa), and TR deltaalpha2 (~237 aa); however, only TR alpha1 is able to bind the ligand ( Lazar et al. 1988). TR alpha1 and TR alpha2 are products of alternative splicing of the primary TR alpha mRNA, whereas TR deltaalpha1 and TR deltaalpha2 arise from transcription of an internal promoter in intron 7 of the TR alpha gene. A truncated form of TR alpha, called p43 for 43-kD, has been shown to regulate mitochondrial transcription Casas et al. 2003. Mice lacking all forms of TR alpha have been shown to be viable, but show reduced linear growth, delayed bone maturation, increased hypothermia, reduced thickness of the intestinal mucosa, lowered heart rates, and lowered serum T4. TR alpha has been linked to chronic fatigue Englebienne et al. 2003.

Gene Name: Thyroid Hormone Receptor, Alpha
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: THRA, AR7, C-ERBA-1, C-erbaalpha, EAR-7.1/EAR-7.2, ERB-T-1, ERBA1, EAR-7, ERBA-related 7, HTR alpha 1, HTR alpha 2, THRA1, Thyroid hormone receptor alpha, T3R, Tralpha2, Triiodothyronine receptor, V-erbA-related protein 7, Thyroid hormone receptor, Tralpha1, NR1A1, THRA3, C-erbA-alpha, CHNG6, EAR7, ERBA, Erba-alpha, THRA2, TR alpha, Tralpha
Target Sequences: NM_003250 NP_003241.2 P10827

Filtered by: None
Target
THRA / THR Alpha (64)
Reactivity
Human (64)
Mouse (17)
Rat (17)
Bovine (9)
Chimpanzee (6)
Dog (10)
Guinea pig (8)
Hamster (9)
Horse (9)
Monkey (20)
Pig (10)
Rabbit (9)
Sheep (9)
Zebrafish (8)
Application
IHC (28)
IHC-P (23)
WB (49)
DB (2)
ELISA (10)
ICC (1)
IF (2)
IP (2)
Peptide-ELISA (3)
Host
rabbit (46)
mouse (17)
goat (1)
Isotype
IgG (14)
IgG1 (15)
IgG2a (2)
Clonality
monoclonal mc (17)
polyclonal pc (47)
Clone
948C3a (2)
OTI2A2 (2)
OTI3E10 (2)
OTI5A8 (2)
OTI5C12 (2)
OTI5E12 (2)
OTI6B7 (2)
OTI7G2 (2)
Format
AP Conjugated (2)
APC (1)
APC Conjugated (3)
Azide-free (2)
Biotin Conjugated (6)
Carrier-free (7)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (6)
HRP Conjugated (6)
PE Conjugated (3)
Unconjugated (36)
Epitope
Ligand-binding Domain (14)
aa1-220 (14)
aa1-490 (12)
aa246-295 (4)
aa325-374 (4)
N-Terminus (2)
10-90 aa, N-terminal (1)
Ala19 (1)
aa10-59 (1)
aa107-139 (1)
aa147-158 (1)
aa317-490 (1)
Publications
No (64)
Showing 1-25 of 64 results

IHC-plus™ THRA / THR Alpha Antibody (Ligand-binding Domain) LS-A6196
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ THRA / THR Alpha Antibody (Ligand-binding Domain, Biotin) LS-A106141
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ THRA / THR Alpha Antibody (Ligand-binding Domain, FITC) LS-A106142
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ THRA / THR Alpha Antibody (Ligand-binding Domain, APC) LS-A106140
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ THRA / THR Alpha Antibody (Ligand-binding Domain, AP) LS-A106139
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ THRA / THR Alpha Antibody (Ligand-binding Domain, Azide-free, HRP) LS-A106143
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ THRA / THR Alpha Antibody (Ligand-binding Domain, PE) LS-A106144
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ THRA / THR Alpha Antibody (aa147-158) LS-B4351
Goat Polyclonal to Human THRA / THR Alpha
Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Hamster, Pig, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-THRA antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Anti-THRA antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.

THRA / THR Alpha Antibody (10-90 aa, N-terminal) LS-C386528
Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00

THRA / THR Alpha Antibody (aa1-490) LS-C370417
Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1: 100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

THRA / THR Alpha Antibody (aa1-490, HRP) LS-C370421
Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Human
ELISA, IHC, IHC-P, WB
HRP Conjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1: 100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

THRA / THR Alpha Antibody (aa1-490, Biotin) LS-C370427
Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Human
ELISA, IHC, IHC-P, WB
Biotin Conjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1: 100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

THRA / THR Alpha Antibody (aa1-490, FITC) LS-C370420
Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Human
ELISA, IHC, IHC-P, WB
FITC Conjugated
50µg  $285.00; 100µg  $385.00
Immunohistochemistry of paraffin-embedded human colon cancer using antibody at 1:100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Immunohistochemistry of paraffin-embedded human breast cancer using antibody at 1: 100 dilution.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

THRA / THR Alpha Antibody LS-C745311
Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Human
ELISA, IF, IHC, IP, WB
Unconjugated
25µl 0.89mg/ml  $235.00
Western blot using the affinity purified anti-THRA antibody shows detection of purified recombinant THRA (lane 1) and THRA present in a 293 cell lysate after transient transfection with THRA (lane 3). No staining is evident in lysates from mock-transfected 293 cells (lane 2). Endogenous THRA is not detected in mouse brain whole cell lysate (lane 4). Nuclear extracts may be required to detect endogenous THRA as the protein localizes within the nucleus. The band at ~55 kDa, indicated by the arrowhead, corresponds to THRA.

THRA / THR Alpha Antibody (aa325-374) LS-C134993
Rabbit Polyclonal to Rat THRA / THR Alpha
Zebrafish, Pig, Horse, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Sheep, Bovine, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $365.00
THRA antibody Western blot of Rat Muscle lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ THRA / THR Alpha Antibody (Ligand-binding Domain) LS-A6194
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ THRA / THR Alpha Antibody (Ligand-binding Domain, Biotin) LS-A106135
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ THRA / THR Alpha Antibody (Ligand-binding Domain, FITC) LS-A106136
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ THRA / THR Alpha Antibody (Ligand-binding Domain, Azide-free, HRP) LS-A106137
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ THRA / THR Alpha Antibody (Ligand-binding Domain, PE) LS-A106138
Rabbit Polyclonal to Human THRA / THR Alpha
Human, Monkey
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-THRA antibody IHC of human surface epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

THRA / THR Alpha Antibody (aa1-220, clone OTI2A2) LS-C339494
Mouse Monoclonal [clone OTI2A2] (IgG1) to Human THRA / THR Alpha
Human
IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-THRA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
IHC of paraffin-embedded Human Ovary tissue using anti-THRA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

THRA / THR Alpha Antibody (aa1-220, clone OTI2A2, Carrier-free) LS-C790535
Mouse Monoclonal [clone OTI2A2] (IgG1) to Human THRA / THR Alpha
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-THRA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-THRA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,

THRA / THR Alpha Antibody (aa317-490) LS-C185387
Rabbit Polyclonal to Human THRA / THR Alpha
Human
ICC, IP, WB
Unconjugated
100µl 0.33mg/ml  $355.00
Immunofluorescence of paraformaldehyde-fixed HeLa using Thyroid Hormone Receptor alpha 2 antibody at 1:500 dilution.
Sample (30 ug of whole cell lysate). A: JurKat. 10% SDS PAGE. THRA antibody diluted at 1:1000.

THRA / THR Alpha Antibody (aa1-220, clone OTI3E10, Carrier-free) LS-C790536
Mouse Monoclonal [clone OTI3E10] (IgG1) to Human THRA / THR Alpha
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-THRA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY THRA. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-THRA.

THRA / THR Alpha Antibody LS-C801856
Rabbit Polyclonal (IgG) to Human THRA / THR Alpha
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunofluorescence Image
Western blot Image
Showing 1-25 of 64 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).