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THPO / TPO / Thrombopoietin

thrombopoietin

Megakaryocytopoiesis is the cellular development process that leads to platelet production. The main functional protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternative promoter usage and differential splicing result in multiple transcript variants differing in the 5' UTR and/or coding region. Multiple AUG codons upstream of the main open reading frame (ORF) have been identified, and these upstream AUGs inhibit translation of the main ORF at different extent.

Gene Name: thrombopoietin
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: THPO, C-mpl ligand, MGDF, MPL ligand, THCYT1, Thrombopoietin nirs variant 1, MKCSF, MPLLG, Thrombopoietin
Target Sequences: NM_000460 NP_000451.1 P40225

☰ Filters
Products
Proteins (31)
Over-Expression Lysate (4)
Recombinant (27)
THPO / TPO / Thrombopoietin (31)
Animal-free (3)
No (31)
6His, C-terminus (1)
6His, N-terminus (2)
6His, N-terminus + 6His, C-terminus (4)
6His-SUMO, N-terminus (1)
GST (2)
His, N-Terminal (3)
His-GST (2)
His-T7 (1)
Myc-DDK (Flag) (4)
Human (14)
Mouse (11)
Rat (4)
293T Cells (2)
CHO Cells (2)
E. coli (17)
HEK 293 Cells (2)
Human Cells (4)
Mammalian Cells (3)
Wheat Germ Extract (1)
Purified (11)
Low endotoxin level (17)
Biologically active (13)
Animal-free (3)
THPO / TPO / Thrombopoietin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
37.82 kDa
100 µg/$494
THPO / TPO / Thrombopoietin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
6His-SUMO, N-terminus
34.7 kDa
1 mg/$1,355; 100 µg/$420; 20 µg/$323
THPO / TPO / Thrombopoietin Protein - Mouse TPO (BL) induces proliferation of M-07e cells.
Select
CHO Cells
None
Biologically active
Less than 1 EU/µg (determined by LAL method).
Predicted molecular mass of approximately 35.5 kD. The protein migrates at about 40 kD in DTT-reducing conditions and about 35 kD in non-reducing condition by SDS-PAGE.The N-terminal amino acid is Ser.
10 µg/$352; 25 µg/$459; 100 µg/$1,049
THPO / TPO / Thrombopoietin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
37.8 kDa
100 µg/$494
THPO / TPO / Thrombopoietin Protein - 12.5% SDS-PAGE of human THPO stained with Coomassie Blue
Select
Wheat Germ Extract
GST
63.8 kDa
2 µg/$439
Select
E. coli
GST
46 kD
1 mg/$1,679; 100 µg/$500; 20 µg/$364
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.4kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353
THPO / TPO / Thrombopoietin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
37.82 kDa
20 µg/$150
THPO / TPO / Thrombopoietin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
37.8 kDa
20 µg/$150
THPO / TPO / Thrombopoietin Protein
Select
E. coli
None
Biologically active
18.7 kDa
10 µg/$388; 100 µg/$1,277; 500 µg/$2,501
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
18.6 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$281; 10 µg/$369
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
18.7 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$282; 10 µg/$370
Select
E. coli
None
Biologically active
Less than 0.1 ng/µg of protein (less than 1EU/µg).
18.7 kDa
2 µg/$268; 10 µg/$349
Select
E. coli
None
Biologically active
Less than 0.01 ng/µg of protein (Less than 0.1 EU/µg).
2 µg/$281; 10 µg/$369
Select
E. coli
None
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
~19 kDa
10 µg/$432; 1 mg/$6,871
Select
Human Cells
6His, N-terminus + 6His, C-terminus
Biologically active
Less than 1 EU/µg (determined by LAL method).
75-90 kDa
10 µg/$402; 1 mg/$3,412; 50 µg/$879; 500 µg/$2,449
THPO / TPO / Thrombopoietin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
6His, N-terminus + 6His, C-terminus
Biologically active
Less than 1.0 EU/µg protein (determined by LAL method).
37.3 kDa
50 µg/$698; 10 µg/$356; 1 mg/$2,837; 500 µg/$1,987
Select
Mammalian Cells
6His, N-terminus + 6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37.3 kDa
10 µg/$317; 50 µg/$524
Select
Mammalian Cells
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.4 kDa
10 µg/$317; 50 µg/$524
Select
CHO Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
30-80 kDa (SDS-PAGE)
50 µg/$432; 10 µg/$296; 1 mg/$2,171
Select
Human Cells
6His, N-terminus + 6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
37.3kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
Select
Human Cells
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
36.4kD
10 µg/$321; 50 µg/$534; 500 µg/$1,680; 1 mg/$2,353
THPO / TPO / Thrombopoietin Protein - Recombinant Thyroid Peroxidase (TPO) by SDS-PAGE
Select
E. coli
His, N-Terminal
25.4kDa
10 µg/$268; 50 µg/$362; 200 µg/$722; 100 µg/$577; 1 mg/$1,755; 500 µg/$1,325; 5 mg/$2,708; 2 mg/$1,934
Viewing 1-25 of 31 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).