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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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AR / Androgen Receptor

androgen receptor

The androgen receptor (AR) is a NR3 Steroid Receptor located on the X chromosome. AR is a phosphoprotein and acts as a steroid hormone-activated transcription factor for androgen-responsive genes. Mutations in the AR gene are associated with androgen insensitivity syndrome (CAIS) or testicular feminization syndrome, Reifenstein syndrome, and Kennedy spinal and bulbar muscular atrophy. They lead to symptoms such as low virilization, reduced sperm production, testicular atrophy, and infertility. Androgen signaling through the androgen receptor (AR) appears to be involved in all aspects of prostate cancer, from initiation to development of treatment resistance. Gain-of-function AR gene mutations and/or altered signaling through AR have been suggested to contribute to disease progression. A recent study showed decreased expression of AR in response to incubation of LNCaP prostate carcinoma cells with PC-SPES, a mixture of eight herbs (Bonham et al. 2002). Two forms of AR that differ in their N termini have been isolated: AR A (87 kD), which is derived from translation of an internal methionine codon (met188), and AR B (110 kD). The two isoforms are expressed in similar tissues; however, AR B generally is the more abundant form.

Gene Name: androgen receptor
Family/Subfamily: NHR , NR3 Steroid receptor
Synonyms: AR, Androgen receptor, Dihydrotestosterone receptor, DHTR, AIS, KD, NR3C4, HUMARA, SBMA, TFM, SMAX1, HYSP1
Target Sequences: NM_000044 NP_000035.2 P10275

Publications (3)

1
Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer. Gonzalez-Angulo AM, Stemke-Hale K, Palla SL, Carey M, Agarwal R, Meric-Berstam F, Traina TA, Hudis C, Hortobagyi GN, Gerald WL, Mills GB, Hennessy BT. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:2472-8. [PubMed:19276248]
2
Abnormal mitochondrial function and impaired granulosa cell differentiation in androgen receptor knockout mice. Wang RS, Chang HY, Kao SH, Kao CH, Wu YC, Yeh S, Tzeng CR, Chang C. International journal of molecular sciences. 2015 16:9831-49. (ICC; Human) [Full Text Article] [PubMed:25941928] [PMC:PMC4463620]
3
ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor. Mounir Z, Korn JM, Westerling T, Lin F, Kirby CA, Schirle M, McAllister G, Hoffman G, Ramadan N, Hartung A, Feng Y, Kipp DR, Quinn C, Fodor M, Baird J, Schoumacher M, Meyer R, Deeds J, Buchwalter G, Stams T, Keen N, Sellers WR, Brown M, Pagliarini RA. eLife. 2016 5: (WB; Human) [Full Text Article] [PubMed:27183006] [PMC:PMC4909395] Related Antibodies: LS-C87494.

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AR / Androgen Receptor (271)
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AR / Androgen Receptor Antibody - Formalin-fixed, paraffin-embedded human prostate stained with peroxidase-conjugate and DAB chromogen. Note nuclear staining of glandular epithelial cells.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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AR / Androgen Receptor Mouse anti-Human Monoclonal (AR 441) Antibody
Dog, Human
GS, IF, IHC, IHC-P, IP, WB
Unconjugated
1 ml/$1,080
AR / Androgen Receptor Antibody - Formalin-fixed, paraffin-embedded human prostate stained with peroxidase-conjugate and DAB chromogen. Note nuclear staining of glandular epithelial cells.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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AR / Androgen Receptor Mouse anti-Human Monoclonal (Biotin) (AR 441) Antibody
Dog, Human
GS, IF, IHC, IHC-P, IP, WB
Biotin Conjugated
100 µl/$365; 500 µl/$845; 1 ml/$1,350
AR / Androgen Receptor Antibody - Immunohistochemistry of Human Prostate Adenocarcinoma stained with anti-Androgen Receptor (AR) antibody
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AR / Androgen Receptor Rabbit anti-Human Monoclonal (N-Terminus) (SP107) Antibody
Human
IHC, IHC-P
Unconjugated
500 µl/$495
AR / Androgen Receptor Antibody - Immunohistochemistry of Human prostate adenocarcinoma stained with anti-AR (C-term) antibody
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AR / Androgen Receptor Rabbit anti-Human Monoclonal (C-Terminus) (SP242) Antibody
Human
IHC, IHC-P
Unconjugated
500 µl/$530
AR / Androgen Receptor Antibody - Anti-Androgen Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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AR / Androgen Receptor Mouse anti-Human Monoclonal (2H8) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$425
AR / Androgen Receptor Antibody - Androgen Receptor Antibody (2µg/ml) staining of paraffin embedded Human Prostate. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
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AR / Androgen Receptor Goat anti-Human Polyclonal (aa2-16) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µg/$405
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (pTyr267) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$425
AR / Androgen Receptor ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$740
AR / Androgen Receptor ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$810
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E. coli
6His, N-terminus
62 kDa
10 µg/$235; 50 µg/$315; 100 µg/$395
AR / Androgen Receptor Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His-SUMO, N-terminus + Myc, C-terminus
1 mg/$1,290; 100 µg/$355; 20 µg/$265
AR / Androgen Receptor ELISA Kit
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DNA Binding Phosphorylation
12 x 8-Well Microstrips
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$640
AR / Androgen Receptor Antibody - Immunoperoxidase of monoclonal antibody to AR on formalin-fixed paraffin-embedded human renal cell carcinoma tissue. [antibody concentration 3 ug/ml].
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AR / Androgen Receptor Mouse anti-Human Monoclonal (1G3) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$365
AR / Androgen Receptor ELISA Kit
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Cell-Based
96-Well Microplate
Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$490
AR / Androgen Receptor ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$590
AR / Androgen Receptor ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
78.125 - 5000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$700
AR / Androgen Receptor Antibody - Formalin-fixed, paraffin-embedded human prostate carcinoma stained with Androgen Receptor antibody (AR441 + DHTR/882).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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AR / Androgen Receptor Mouse anti-Human Monoclonal (aa300-316) (AR441 + DHTR/882) Antibody
Human
IF, IHC, IHC-P
Unconjugated
20 µg/$295; 100 µg/$465
AR / Androgen Receptor Antibody - Immunohistochemical analysis of Androgen Receptor (pS650) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (pSer650) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$245
AR / Androgen Receptor Antibody - Immunohistochemistry of paraffin-embedded mouse brain tissue.
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AR / Androgen Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$215; 50 µl/$235; 100 µl/$315; 200 µl/$425
AR / Androgen Receptor Antibody - Immunohistochemical analysis of Androgen Receptor staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$275
AR / Androgen Receptor Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
99 kDa
100 µg/$485
AR / Androgen Receptor Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (aa611-660) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$425
AR / Androgen Receptor Antibody - Detection of Human Androgen Receptor by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Androgen Receptor used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC, IP, WB
Unconjugated
100 µl/$405
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$740
AR / Androgen Receptor Antibody - Immunofluorescence analysis of HeLa cells, using Androgen Receptor (Phospho-Ser94) Antibody. The picture on the right is blocked with the phospho peptide.
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AR / Androgen Receptor Rabbit anti-Human Polyclonal (pSer94) Antibody
Mouse, Human
IF, Peptide-ELISA
Unconjugated
50 µl/$265; 100 µl/$325
Viewing 1-25 of 271 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).