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PDGFRA / PDGFR Alpha

platelet-derived growth factor receptor, alpha polypeptide

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca2+ and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.

Gene Name: platelet-derived growth factor receptor, alpha polypeptide
Family/Subfamily: Protein Kinase , PDGF Receptor
Synonyms: PDGFRA, CD140A, CD140a antigen, PDGFalphaR, PDGFR2, PDGFRalpha, AlphaPDGFR, RHEPDGFRA, PDGF receptor alpha, PDGFR-2, PDGFRA/BCR fusion, APDGFR, Pdgf alpha-receptor, PDGF-R-alpha, PDGFR-alpha
Target Sequences: NM_006206 NP_006197.1 P16234

Publications (3)

1
KIAA1199 expression and hyaluronan degradation colocalize in multiple sclerosis lesions. Marella M, Jadin L, Keller GA, Sugarman BJ, Frost GI, Shepard HM. Glycobiology. 2018 December;28:958-967. [Full Text Article] [PubMed:30007349] [PMC:PMC6243203]
2
A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor alpha gene as a quantitative trait locus for eye size in white Europeans. Guggenheim JA, McMahon G, Kemp JP, Akhtar S, St Pourcain B, Northstone K, Ring SM, Evans DM, Smith GD, Timpson NJ, Williams C. Molecular vision. 2013 19:243-53. [Full Text Article] [PubMed:23401653] [PMC:PMC3566893] Related Antibodies: LS-B6056.
3
Imatinib mesylate plus hydroxyurea chemotherapy for cerebellar meningioma in a Belgian Malinois dog. Jung HW, Lee HC, Kim JH, Jang HM, Moon JH, Sur JH, Ha J, Jung DI. The Journal of veterinary medical science. 2014 76:1545-8. (IHC; Canine) [PubMed:25131949] [PMC:PMC4272992] Related Antibodies: LS-B6056.

☰ Filters
Antibodies (212)
Proteins (25)
ELISA Kits (19)
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Custom (2)
Over-Expression Lysate (2)
Primary (212)
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PDGFRA / PDGFR Alpha (256)
Human (194)
Mouse (93)
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07 (1)
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1A10A8 (1)
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2E9 (1)
35248 (57/20) (1)
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aa789-1089 (14)
Tyr720 (8)
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aa1048-1077 (8)
aa170-387 (8)
aa678-706 (8)
pTyr762 (8)
Tyr754 (7)
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aa32-324 (5)
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690-770 aa (2)
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790-870 aa (2)
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960-1040 aa (1)
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Ile843 (1)
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aa1000-C-term (1)
aa1031-1080 (1)
aa1035-1053 (1)
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PDGFRA / PDGFR Alpha Antibody - Anti-PDGFRA antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Cancer
PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal (aa1000-C-term) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$565
PDGFRA / PDGFR Alpha Antibody - Anti-PDGFRA antibody IHC of human breast, fibroblasts. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
125 µl/$505
PDGFRA / PDGFR Alpha Antibody - Anti-PDGFRA antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$515
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PDGFRA / PDGFR Alpha Rabbit anti-Human Monoclonal (C-Terminus) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$625
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PDGFRA / PDGFR Alpha Mouse anti-Human Monoclonal (Extracellular Domain) (35248 (57/20)) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.1 mg/$363
PDGFRA / PDGFR Alpha Antibody - Staining of NIH/3T3 cells with 0.5 ug of Purified Rat IgG2a isotype control (open histogram) or 0.5 ug of Purified anti-mouse CD140a (APA5) (colored histogram) followed by Biotin Anti-Rat IgG and SAv-PE. Total viable cells were used for analysis.
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PDGFRA / PDGFR Alpha Rat anti-Mouse Monoclonal (APA5) Antibody
Mouse
Flo, IHC, IHC-Fr, WB
Unconjugated
50 µg/$245; 100 µg/$277
PDGFRA / PDGFR Alpha Antibody - Immunofluorescent analysis of PDGFR alpha staining in NIH3T3 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
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PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Bovine, Mouse, Dog, Rat, Pig, Human, Monkey
ICC, IF, WB
Unconjugated
100 µl/$289
PDGFRA / PDGFR Alpha Antibody - Staining of NIH/3T3 cells with 0.5 ug of PE Rat IgG2a isotype control (open histogram) or 0.5 ug of PE anti-mouse CD140a (APA5) (colored histogram). Total viable cells were used for analysis. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PDGFRA / PDGFR Alpha Rat anti-Mouse Monoclonal (PE) (APA5) Antibody
Mouse
Flo
PE Conjugated
50 µg/$330
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PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal (pTyr754) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$725
PDGFRA / PDGFR Alpha Antibody - Anti-PDGFRA antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Cancer
PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
PDGFRA / PDGFR Alpha Antibody - Anti-PDGFRA / PDGFR Alpha antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P
Unconjugated
250 µl/$525
PDGFRA / PDGFR Alpha Antibody - Surface staining of CD140a in CD140a-transfected 3T3 cells using anti-CD140a (16A1) APC.
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PDGFRA / PDGFR Alpha Mouse anti-Human Monoclonal (APC) (16A1) Antibody
Human
Flo, ICC
APC Conjugated
100 Tests/$355
PDGFRA / PDGFR Alpha Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$369; 200 µl/$411
PDGFRA / PDGFR Alpha Antibody - Western blot of PDGFR-alpha antibody
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PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal (700-780 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
PDGFRA / PDGFR Alpha Antibody - IHC of paraffin-embedded Human colon tissue using anti-PDGFRA mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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PDGFRA / PDGFR Alpha Mouse anti-Human Monoclonal (aa32-324) (2E9) Antibody
Human
IHC, WB
Unconjugated
100 µl/$409
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PDGFRA / PDGFR Alpha Rat anti-Mouse Monoclonal Antibody
Mouse
ELISA, Flo, IHC, WB
Unconjugated
100 µg/$688
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PDGFRA / PDGFR Alpha Rat anti-Mouse Monoclonal (APC) Antibody
Mouse
ELISA, Flo, IHC, WB
APC Conjugated
100 µl/$827
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HEK 293 Cells
His, C-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
57kD
10 µg/$253; 50 µg/$358; 500 µg/$971; 1 mg/$1,168
PDGFRA / PDGFR Alpha Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
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PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal Antibody
IHC-P
Unconjugated
50 µg/$460
PDGFRA / PDGFR Alpha Antibody - Western blot of Phospho-PDGFR-alpha (Y849) antibody
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PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal (790-870 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µl/$279; 100 µl/$309; 200 µl/$379
Select
PDGFRA / PDGFR Alpha Mouse anti-Human Monoclonal (16A1) Antibody
Human
Flo, ICC
Unconjugated
0.1 mg/$306
PDGFRA / PDGFR Alpha Antibody - 1:100 staining human kidney tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
PDGFRA / PDGFR Alpha Antibody - Western blot of 293 cell lysate using PDGFRalpha Antibody
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PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$347
PDGFRA / PDGFR Alpha Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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PDGFRA / PDGFR Alpha Rabbit anti-Human Polyclonal (aa1048-1077) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$376
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PDGFRA / PDGFR Alpha Mouse anti-Human Monoclonal (5B11G5) Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
0.1 mg/$426
Viewing 1-25 of 256 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).