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Insulin

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.

Gene Name: Insulin
Family/Subfamily: Hormone , not assigned-Hormone
Synonyms: INS, IRDN, IDDM2, Preproinsulin, ILPR, Insulin, MODY10, Proinsulin
Target Sequences: NM_000207 NP_000198.1 P01308

Publications (5)

1
Transgenic pigs with pancreas-specific expression of green fluorescent protein. Matsunari H, Kobayashi T, Watanabe M, Umeyama K, Nakano K, Kanai T, Matsuda T, Nagaya M, Hara M, Nakauchi H, Nagashima H. The Journal of reproduction and development. 2014 60:230-7. (IHC; Pig) [PubMed:24748398] [PMC:PMC4085388] Related Antibodies: LS-C24686.
2
Compensation of Disabled Organogeneses in Genetically Modified Pig Fetuses by Blastocyst Complementation. Matsunari H, Watanabe M, Hasegawa K, Uchikura A, Nakano K, Umeyama K, Masaki H, Hamanaka S, Yamaguchi T, Nagaya M, Nishinakamura R, Nakauchi H, Nagashima H. Stem cell reports. 2020 January;14:21-33. [Full Text Article] [PubMed:31883918] [PMC:PMC6962638] Related Antibodies: LS-C24686.
3
Lipocalin-2 is an anorexigenic signal in primates. Peristera-Ioanna Petropoulou, Ioanna Mosialou, Steven Shikhel, Lihong Hao, Konstantinos Panitsas, Brygida Bisikirska, Na Luo, Fabiana Bahna, Jongho Kim, Patrick Carberry, Francesca Zanderigo, Norman Simpson, Mihran Bakalian, Suham Kassir, Lawrence Shapiro, Mark D Underwood, Christina M May, Kiran Kumar Soligapuram Sai, Matthew J Jorgensen, Cyrille B Confavreux, Sue Shapses, Blandine Laferrère, Akiva Mintz, J John Mann, Mishaela Rubin, Stavroula Kousteni. eLife. 2020 November;9: [Full Text Article] [PubMed:33231171] [PMC:PMC7685704]
4
Hyperglycemia promotes K-Ras-induced lung tumorigenesis through BASCs amplification. Micucci C, Orciari S, Catalano A. PloS one. 9:e105550. [Full Text Article] [PubMed:25144301] [PMC:PMC4140809] Related Antibodies: LS-B2526.
5
Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs. Matsunari H, Nagashima H, Watanabe M, Umeyama K, Nakano K, Nagaya M, Kobayashi T, Yamaguchi T, Sumazaki R, Herzenberg LA, Nakauchi H. Proceedings of the National Academy of Sciences of the United States of America. 2013 Mar;110:4557-62. [Full Text Article] [PubMed:23431169] [PMC:PMC3607052] Related Antibodies: LS-C24686.
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Antibodies (345)
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Insulin (451)
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monoclonal mc (237)
polyclonal pc (104)
recombinant monoclonal rmc (4)
06 (1)
14 (1)
17 (1)
1C5A (1)
1D3 (2)
1D6 (1)
1G4 (2)
1H8 (1)
2D11 (1)
2D11.H5 (1)
2D11-H5 (1)
2D11-H5 or INS05 (3)
3A1 (1)
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423631 (1)
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E2-E3 + 2D11-H5 or INS04 + INS05 (3)
E2-E3 or INS04 (3)
E6E5 (1)
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IN-05 (4)
INS04 (1)
INS04 + INS05 (2)
INS05 (1)
IRDN/1980R (2)
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K36ac10 (1)
K36aC10 (1)
KC36AC10, aka ISL-8J (1)
M322216 (1)
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Insulin Antibody - Anti-Insulin antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Insulin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Flo, ICC, IF, IHC, IHC-P
Unconjugated
50 µl/$525
Insulin Antibody - Anti-Insulin antibody IHC of human pancreas, islets of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Insulin Mouse anti-Rat Monoclonal (D3E7) Antibody
Mouse, Bovine, Rat, Pig, Human
ELISA, IHC, IHC-Fr, IHC-P
Unconjugated
0.05 mg/$515
Insulin Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Insulin Mouse anti-Human Monoclonal (E2E3) Antibody
Human
ELISA, IHC, IHC-Fr, IHC-P
Unconjugated
50 µg/$505
Insulin Antibody - Anti-Insulin antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Insulin Mouse anti-Human Monoclonal (2D11.H5) Antibody
Human
DB, ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µg/$625
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Insulin Guinea pig anti-Pig Polyclonal Antibody
Pig
ELISA, IHC
Unconjugated
1 ml/$543
Insulin Antibody - Anti-Insulin antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Insulin Mouse anti-Human Monoclonal (HRP) (8E2) Antibody
Human
ELISA, IHC, IHC-P
HRP Conjugated
50 µg/$565
Insulin Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Insulin Rabbit anti-Human Polyclonal (aa 25-110) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$460
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Insulin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
50 µg/$284; 100 µg/$351
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Insulin Mouse anti-Human Monoclonal (K36aC10) Antibody
Rabbit, Dog, Guinea pig, Sheep, Bovine, Rat, Cat, Human
IF, IHC, IHC-P, RIA
Unconjugated
100 µl/$762
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Insulin Mouse anti-Human Monoclonal (Biotin) (D3E7) Antibody
Human
ELISA, IHC, IHC-Fr
Biotin Conjugated
1 mg/$817
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Insulin Guinea pig anti-Pig Polyclonal Antibody
Pig
DB, ELISA, IF
Unconjugated
10 mg/$447
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Insulin Guinea pig anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
1 ml/$355
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Insulin Mouse anti-Human Monoclonal (7F8) Antibody
Pig, Human
ELISA, SwELISA
Unconjugated
1 mg/$811
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Insulin Chicken anti-Human Polyclonal Antibody
Mouse, Dog, Rat, Pig, Cat, Human
ELISA, WB
Unconjugated
100 µg/$418
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Insulin Guinea pig anti-Human Polyclonal Antibody
Human
IHC
Unconjugated
500 µl/$266
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Insulin Guinea pig anti-Human Polyclonal Antibody
Bovine, Pig, Human
ELISA
Unconjugated
200 µg/$762
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Insulin Mouse anti-Human Monoclonal (Magnetic beads) (ISL-8J) Antibody
Mouse, Rat, Human
IP
Magnetic beads Conjugated
200 µl/$363
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Insulin Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
Insulin ELISA Kit
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Sandwich
96-Well Microplate
Monkey
10 - 160 µIU/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$848
Insulin ELISA Kit
Select
Sandwich
96-Well Microplate
Chicken
0.31 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$730
Insulin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Dog
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$785
Insulin Protein - SDS-PAGE under reducing conditions and visualized by Coomassie blue staining
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E. coli
6His, N-terminus
12 kDa
10 µg/$255; 50 µg/$305
Insulin Protein - Recombinant Insulin By SDS-PAGE
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E. coli
His, N-Terminal
9.9 kDa
10 µg/$267; 50 µg/$393; 100 µg/$627; 200 µg/$784; 1 mg/$1,781
Insulin ELISA Kit
Select
Sandwich
96-Well Microplate
Pig
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$730
Insulin Antibody - Anti-Insulin antibody IHC of human pancreas, islets of Langerhans. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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Insulin Mouse anti-Pig Monoclonal (INS04) Antibody
Pig, Human
IHC, IHC-P
Unconjugated
250 µl/$585
Viewing 1-25 of 451 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).