Products
Research Areas
COVID-19
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, Proforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

CFTR

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

CFTR (Cystic Fibrosis Transmembrane Conductance Regulator), sometimes also referred as ABCC7 (ATP-binding cassette, Subfamily C, Member 7), is a member of the ATP binding cassette (ABC) transporter family. CFTR functions as a chloride channel and controls the regulation of other transport pathways. Homozygous mutations in the CFTR gene cause cystic fibrosis (CF), formerly known as mucoviscidosis, a common hereditary disorder characterized by severe abnormalities in respiratory, digestive and other organ systems. Approximately 70% of the mutations in CF patients correspond to a specific deletion of 3 base pairs, which results in the loss of a phenylalanine at position 508. The approaches aimed to restore the CFTR gene function in CF patients are the subject of intensive research and include the development of gene therapy protocols. In addition to CF syndrome, CFTR mutations were found in patients suffering from bilateral aplasia of the vas deferens (CBAVD). The high frequency of CFTR defects in the human population can be explained by increased resistance to infectious diseases in heterozygous mutation carriers. Alternative splice variants have been described, many of which result from mutations in the CFTR gene.

Gene Name: cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
Family/Subfamily: Transporter , ATP-binding cassette - ABCC/MRP
Synonyms: CFTR, ABC35, ABCC7, CF, DJ760C5.1, MRP7, CFTR/MRP, TNR-CFTR
Target Sequences: NM_000492 NP_000483.3 P13569

Publications (2)

1
Heterogeneous expression of CFTR in insulin-secreting ß-cells of the normal human islet. Mauricio Di Fulvio, Marika Bogdani, Myrian Velasco, Timothy S McMillen, Cecilia Ridaura, Lisa Kelly, Mohammed M Almutairi, Shams Kursan, Abu A Sajib, Marcia Hiriart, Lydia Aguilar-Bryan. PloS one. 2020 December;15:e0242749. [Full Text Article] [PubMed:33264332] [PMC:PMC7710116] Related Antibodies: LS-B5115.
2
Microparticle-mediated transfer of the viral receptors CAR and CD46, and the CFTR channel in a CHO cell model confers new functions to target cells. Gonzalez G, Vituret C, Di Pietro A, Chanson M, Boulanger P, Hong SS. PloS one. 2012 7:e52326. [Full Text Article] [PubMed:23284987] [PMC:PMC3527531] Related Antibodies: LS-C14758.

☰ Filters
Antibodies (64)
ELISA Kits (10)
Proteins (2)
Primary (64)
Recombinant (2)
Sandwich (9)
Sandwich CLIA (1)
CFTR (76)
Human (68)
Mouse (23)
Rat (16)
Bovine (1)
Chicken (1)
Guinea pig (2)
Monkey (3)
Pig (1)
Rabbit (2)
Sheep (2)
IHC (26)
IHC-P (23)
WB (50)
Flo (2)
ELISA (16)
ICC (9)
IF (26)
IP (33)
Peptide-ELISA (1)
rabbit (19)
mouse (42)
goat (1)
rabbit-new zealand white (2)
Product Group
IHCPlus (3)
PathPlus Cancer (3)
IgG (11)
IgG1 (18)
IgG1,k (8)
IgG2a (9)
IgG2a,k (2)
IgG2b (4)
IgM (1)
monoclonal mc (42)
polyclonal pc (18)
recombinant monoclonal rmc (4)
CFTR/1341 (2)
CFTR/1643 (2)
CFTR/1775R (2)
CFTR/1785 (2)
CFTR/2290R (2)
CFTR1-1 (2)
L12B4 (1)
M3A7 (2)
SPM176 (3)
12 x 8-Well Microstrips (1)
96-Well Microplate (2)
96-Well Strip Plate (7)
AP Conjugated (4)
APC Conjugated (4)
Azide-free (9)
Biotin Conjugated (4)
BSA-free (5)
Carrier-free (2)
FITC Conjugated (4)
HRP Conjugated (4)
PE Conjugated (4)
Unconjugated (40)
C-Terminus (3)
aa 258-385 (2)
aa25-36 (2)
680-760 aa (1)
Glu733 (1)
aa103-117 (1)
aa1365-1395 (1)
aa1400-1450 (1)
aa2-14 (1)
aa650-700 (1)
aa716-755 (1)
p737 (1)
pSer737 (1)
No (74)
Yes (2)
Cell Lysates (2)
Plasma (4)
Serum (4)
Tissue Homogenates (4)
GST, N-terminus (1)
His-GST, N-terminus (1)
Human (2)
E. coli (1)
Wheat Germ Extract (1)
Purified (1)
Low endotoxin level (1)
CFTR Antibody - Anti-CFTR antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Select
Cancer
CFTR Goat anti-Human Polyclonal (aa2-14) Antibody
Sheep, Bovine, Human, Monkey
IHC-P, Peptide-ELISA
Unconjugated
50 µg/$440
CFTR Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
CFTR Mouse anti-Human Monoclonal (aa25-36) Antibody
Human
ICC, IP, WB
Unconjugated
100 µg/$485
CFTR Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer
CFTR Mouse anti-Human Monoclonal (L12B4) Antibody
Mouse, Rat, Human
IF, IHC-P, IP, WB
Unconjugated
250 µl/$460
Select
CFTR Mouse anti-Human Monoclonal (aa103-117) Antibody
Guinea pig, Human
IF, IP, WB
Unconjugated
100 µl/$762
CFTR Antibody - Formalin-fixed, paraffin-embedded human pancreas stained with peroxidase-conjugate and AEC chromogen. Note membrane staining of epithelial cells in the intercalated ducts.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
CFTR Mouse anti-Human Monoclonal (M3A7) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, IP
Unconjugated
100 µl/$374; 500 µl/$751; 1 ml/$949
CFTR Antibody - Formalin-fixed, paraffin-embedded human pancreas stained with peroxidase-conjugate and AEC chromogen. Note membrane staining of epithelial cells in the intercalated ducts.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
CFTR Mouse anti-Human Monoclonal (Azide-free) (M3A7) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, IP
Unconjugated, Azide-free
100 µl/$819; 200 µl/$979
CFTR Antibody - Immunohistochemical analysis of CFTR staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX. w
Select
CFTR Rabbit anti-Human Polyclonal (aa716-755) Antibody
Rabbit, Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$289
CFTR Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
CFTR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$440
CFTR ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Tissue Homogenates
1 Plate/$693
CFTR ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$821
CFTR Antibody - Anti-CFTR antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
CFTR Rabbit anti-Human Polyclonal (Glu733) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$440
CFTR Antibody - Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
CFTR Rabbit anti-Human Polyclonal (680-760 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Select
CFTR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
200 µl/$413
CFTR Antibody - Western blot analysis of extracts of various cells.
Select
CFTR Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
Select
CFTR Mouse anti-Human Monoclonal (aa25-36) (Azide-free) Antibody
Human
ICC, IHC, IHC-P, IP, WB
Unconjugated, Azide-free
100 µl/$831
Select
CFTR Mouse anti-Human Monoclonal (aa1365-1395) Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
200 µg/$833
Select
CFTR Mouse anti-Human Monoclonal (HRP) Antibody
Human
IHC, IP, WB
HRP Conjugated
100 µl/$900
Select
CFTR Mouse anti-Human Monoclonal (FITC) Antibody
Human
IF, IP, WB
FITC Conjugated
100 µl/$870
Select
CFTR Mouse anti-Human Monoclonal (PE) Antibody
Human
IF, IP, WB
PE Conjugated
100 µl/$870
Select
CFTR Mouse anti-Human Monoclonal (APC) Antibody
Human
IF, IHC, IP, WB
APC Conjugated
100 µl/$870
Select
CFTR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Sheep, Human
ELISA, WB
Unconjugated
100 µg/$350
Select
CFTR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
0.1 mg/$375
CFTR Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control. (Left lane) or pCMV6-ENTRY CFTR. (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates. (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CFTR rabbit polyclonal antibody.
Select
CFTR Rabbit anti-Human Polyclonal Antibody
Mouse, Human
WB
Unconjugated
100 µl/$391
CFTR Antibody
Select
CFTR Mouse anti-Human Monoclonal (CFTR1-1) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated
20 µg/$354; 100 µg/$550
CFTR Antibody -  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
CFTR Mouse anti-Human Monoclonal (Azide-free, BSA-free) (CFTR1-1) Antibody
Mouse, Human
Flo, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$550
Viewing 1-25 of 76 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).