CDKN1A / WAF1 / p21

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

CDKN1A / WAF1 / p21 is a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

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Products

Proteins (12)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

CDKN1A / WAF1 / p21 (12)

Publications

No (12)

Tag

6His, N-terminus (2)

GST (3)

GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-S (1)

Myc-DDK (Flag) (3)

Species

Human (9)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (6)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (4)

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Mouse CDKN1A / WAF1 / p21 Protein (Recombinant His, N-Terminal) (Ser2-Pro159) - LS-G132684

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

21kDa

Price:

10 µg/$283; 50 µg/$452; 200 µg/$902; 100 µg/$722; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human CDKN1A / WAF1 / p21 Protein (Recombinant GST) (Full Length) - LS-G20593

Source:

E. coli

Tag:

GST

Molecular Weight:

45.5 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human CDKN1A / WAF1 / p21 Protein (Recombinant 6His, N-terminus) (aa1-164) - LS-G15527

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

19.6 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human CDKN1A / WAF1 / p21 Protein (Recombinant His) - LS-G1949

Source:

E. coli

Tag:

His

Price:

20 µg/$361; 100 µg/$554; 10 µg/$292; 50 µg/$411; 250 µg/$1,100; 500 µg/$1,579

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CDKN1A / WAF1 / p21 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107917

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.9 kDa

Price:

100 µg/$494

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Rat CDKN1A / WAF1 / p21 Protein (Recombinant His-S) (aa1-164) - LS-G25487

Source:

E. coli

Tag:

His-S

Molecular Weight:

22.0 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Human CDKN1A / WAF1 / p21 Protein (Recombinant GST) (Full Length) - LS-G27874

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

43.78 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CDKN1A / WAF1 / p21 Protein (Recombinant GST) (Full Length) - LS-G27876

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

43.67 kDa

Price:

10 µg/$479; 25 µg/$670

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Human CDKN1A / WAF1 / p21 Protein (Recombinant 6His, N-terminus) (Ser2-Pro164) - LS-G26628

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

20 kDa

Price:

10 µg/$265; 50 µg/$315; 100 µg/$365

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Human CDKN1A / WAF1 / p21 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75359

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.9 kDa

Price:

20 µg/$150

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Human CDKN1A / WAF1 / p21 Protein (Recombinant GST, N-terminus) (aa65-164) - LS-G58084

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human CDKN1A / WAF1 / p21 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65326

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.9 kDa

Price:

20 µg/$1,107

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