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TACR1 / NK1R

tachykinin receptor 1

Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing.

Gene Name: tachykinin receptor 1
Family/Subfamily: GPCR , Tachykinin
Synonyms: TACR1, Neurokinin receptor 1, NK-1R, Nk1 tachykinin receptor, NK1R, TAC1R, Tachykinin 1 receptor, NKIR, Substance-P receptor, Neurokinin 1 receptor, NK-1 receptor, Tachykinin receptor 1
Target Sequences: NM_001058 NP_001049.1 P25103

Publications (22)

1
Phosphorylated cAMP response element binding protein increases in neurokinin-1 receptor-immunoreactive neurons in rat spinal cord in response to formalin-induced nociception. Anderson LE, Seybold VS. Neuroscience letters. 2000 283:29-32. [PubMed:10729626]
2
Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex. Tooney PA, Au GG, Chahl LA. Neuroscience letters. 2000 283:185-8. (IHC; Human) [PubMed:10754218]
3
Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Setou M, Nakagawa T, Seog DH, Hirokawa N. Science (New York, N.Y.). 2000 288:1796-802. [PubMed:10846156]
4
Localization of NK1 and NK3 receptors in guinea-pig brain. Yip J, Chahl LA. Regulatory peptides. 2001 98:55-62. [PubMed:11179779]
5
Increased tachykinin NK(1) receptor immunoreactivity in the prefrontal cortex in schizophrenia. Tooney PA, Crawter VC, Chahl LA. Biological psychiatry. 2001 49:523-7. (IHC; Human) [PubMed:11257237]
6
NK-1 receptor gene expression is related to pain in chronic pancreatitis. Shrikhande SV, Friess H, di Mola FF, Tempia-Caliera A, Conejo Garcia JR, Zhu Z, Zimmermann A, Bchler MW. Pain. 2001 91:209-17. (IHC; Human) [PubMed:11275376]
7
Temporal decrease in renal sensory responses in rats after chronic ligation of the bile duct. Ma MC, Huang HS, Chien CT, Wu MS, Chen CF. American journal of physiology. Renal physiology. 2002 283:F164-72. [PubMed:12060598]
8
The expression of neurokinin-1 receptor at striatal and pallidal levels in normal human brain. Mounir S, Parent A. Neuroscience research. 2002 44:71-81. [PubMed:12204295]
9
Paraventricular vasopressin-containing neurons project to brain stem and spinal cord respiratory-related sites. Kc P, Haxhiu MA, Tolentino-Silva FP, Wu M, Trouth CO, Mack SO. Respiratory Physiology & Neurobiology. 2002 133:75-88. [PubMed:12385733]
10
A neurochemically distinct dorsal raphe-limbic circuit with a potential role in affective disorders. Commons KG, Connolley KR, Valentino RJ. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2003 28:206-15. [PubMed:12589373]
11
Depletion of ventromedullary NK-1 receptor-immunoreactive neurons in multiple system atrophy. Benarroch EE, Schmeichel AM, Low PA, Parisi JE. Brain : a journal of neurology. 2003 126:2183-90. (IHC; Human) [PubMed:12902309]
12
Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation. Lai JP, Ho WZ, Kilpatrick LE, Wang X, Tuluc F, Korchak HM, Douglas SD. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:7771-6. (ICC; Human) [PubMed:16675550] [PMC:PMC1457089]
13
Expression of NK-1 and NK-3 tachykinin receptors in pancreatic acinar cells after acute experimental pancreatitis in rats. Broccardo M, Linari G, Agostini S, Amadoro G, Carpino F, Ciotti MT, Petrella C, Petrozza V, Severini C, Improta G. American journal of physiology. Gastrointestinal and liver physiology. 2006 291:G518-24. [PubMed:16782701]
14
Neurokinin-1 receptor activation in Botzinger complex evokes bradypnoea. Fong AY, Potts JT. The Journal of physiology. 2006 575:869-85. (IHC; Rat) [PubMed:16825299] [PMC:PMC1995693]
15
Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection. Hazlett LD, McClellan SA, Barrett RP, Liu J, Zhang Y, Lighvani S. Investigative ophthalmology & visual science. 2007 48:797-807. (IHC; Mouse) [PubMed:17251480]
16
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. Schmidtko A, Gao W, Knig P, Heine S, Motterlini R, Ruth P, Schlossmann J, Koesling D, Niederberger E, Tegeder I, Friebe A, Geisslinger G. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 28:8568-76. (IHC; Mouse) [PubMed:18716216]
17
Cardiac damage after lesions of the nucleus tractus solitarii. Nayate A, Moore SA, Weiss R, Taktakishvili OM, Lin LH, Talman WT. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 296:R272-9. (IHC; Rat) [PubMed:19020288] [PMC:PMC2643979]
18
Substance P receptor activation induces downregulation of the AMPA receptor functionality in cortical neurons from a genetic model of Amyotrophic Lateral Sclerosis. Caioli S, Curcio L, Pieri M, Antonini A, Marolda R, Severini C, Zona C. Neurobiology of disease. 2011 44:92-101. [PubMed:21726643]
19
Kinetics of neuronal contribution during the development of a contact allergic reaction. Altawil R, Lystrm J, El-Nour H. Archives of dermatological research. 2012 304:273-81. (IHC; Human) [PubMed:22198823]
20
Substance P alterations in skin and brain of chronically stressed atopic-like mice. Grip L, Lonne-Rahm SB, Holst M, Johansson B, Nordlind K, Theodorsson E, El-Nour H. Journal of the European Academy of Dermatology and Venereology : JEADV. 2013 27:199-205. (ICC, IHC; Mouse) [PubMed:22251186]
21
Visceral hypersensitivity in symptomatic diverticular disease and the role of neuropeptides and low grade inflammation. Humes DJ, Simpson J, Smith J, Sutton P, Zaitoun A, Bush D, Bennett A, Scholefield JH, Spiller RC. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2012 24:318-e163. (IHC; Human) [PubMed:22276853]
22
Sudden death and myocardial lesions after damage to catecholamine neurons of the nucleus tractus solitarii in rat. Talman WT, Dragon DN, Jones SY, Moore SA, Lin LH. Cellular and molecular neurobiology. 2012 32:1119-26. (ICC, IHC-Fr; Rat) [PubMed:22484855]
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Filtered by: None
Target
TACR1 / NK1R (63)
Reactivity
Human (59)
Mouse (19)
Rat (29)
Bat (2)
Bovine (9)
Chicken (3)
Chimpanzee (1)
Dog (9)
Guinea pig (15)
Hamster (7)
Horse (9)
Monkey (23)
Rabbit (10)
Sheep (1)
Xenopus (1)
Application
IHC (41)
IHC-Fr (5)
IHC-P (27)
WB (34)
Flo (4)
ELISA (15)
ICC (2)
IF (6)
Peptide-ELISA (3)
Host
rabbit (60)
mouse (2)
goat (1)
Isotype
IgG (24)
IgG2a,k (1)
IgG2b (1)
Clonality
monoclonal mc (2)
polyclonal pc (61)
Clone
11n182 (1)
1F7 (1)
Format
AP Conjugated (4)
APC Conjugated (4)
Azide-free (3)
Biotin Conjugated (6)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (4)
Unconjugated (32)
Epitope
C-Terminus (17)
aa219-248 (8)
Extracellular Domain (7)
N-Terminus (5)
180-260 aa, Internal (1)
Internal (1)
Lys245 (1)
aa150-200 (1)
aa211-260 (1)
aa227-239 (1)
aa231-245 (1)
aa264-291 (1)
aa363-397 (1)
aa385-407 (1)
Publications
No (63)
Showing 1-25 of 63 results

IHC-plus™ TACR1 / NK1R Antibody (Extracellular Domain) LS-A1339
Rabbit Polyclonal to Human TACR1 / NK1R
Dog, Bovine, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TACR1 /  NK1R antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TACR1 / NK1R Antibody (Extracellular Domain, Biotin) LS-A100951
Rabbit Polyclonal to Human TACR1 / NK1R
Dog, Bovine, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl  $650.00
Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TACR1 /  NK1R antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TACR1 / NK1R Antibody (Extracellular Domain, FITC) LS-A100952
Rabbit Polyclonal to Human TACR1 / NK1R
Dog, Bovine, Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl  $650.00
Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TACR1 /  NK1R antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TACR1 / NK1R Antibody (Extracellular Domain, AP) LS-A100949
Rabbit Polyclonal to Human TACR1 / NK1R
Dog, Bovine, Human, Monkey
IHC, IHC-P
AP Conjugated
100µl  $650.00
Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TACR1 /  NK1R antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TACR1 / NK1R Antibody (Extracellular Domain, APC) LS-A100950
Rabbit Polyclonal to Human TACR1 / NK1R
Dog, Bovine, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TACR1 /  NK1R antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TACR1 / NK1R Antibody (Extracellular Domain, Azide-free, HRP) LS-A100953
Rabbit Polyclonal to Human TACR1 / NK1R
Dog, Bovine, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl  $650.00
Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TACR1 /  NK1R antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TACR1 / NK1R Antibody (Extracellular Domain, PE) LS-A100954
Rabbit Polyclonal to Human TACR1 / NK1R
Dog, Bovine, Human, Monkey
IHC, IHC-P
PE Conjugated
100µl  $650.00
Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-TACR1 /  NK1R antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

IHC-plus™ TACR1 / NK1R Antibody (N-Terminus) LS-B500
Rabbit Polyclonal to Human TACR1 / NK1R
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
100µl 1mg/ml  $425.00
Anti-Neurokinin 1 Receptor antibody IHC of human brain, putamen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TACR1 / NK1R Antibody (N-Terminus, Biotin) LS-C142044
Rabbit Polyclonal to Human TACR1 / NK1R
Mouse, Rat, Human
Flo, IHC, IHC-P, WB
Biotin Conjugated
100µl  $365.00
Anti-Neurokinin 1 Receptor antibody IHC of human brain, putamen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Brain, Basal Nucleus of Meynert, Neurons 40X.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TACR1 / NK1R Antibody (N-Terminus, DY650) LS-C142045
Rabbit Polyclonal to Human TACR1 / NK1R
Rat, Human
Flo, IHC, IHC-P, WB
DY650 Conjugated
100µl  $365.00
Anti-Neurokinin 1 Receptor antibody IHC of human brain, putamen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Brain, Basal Nucleus of Meynert, Neurons 40X.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TACR1 / NK1R Antibody (N-Terminus, DY488) LS-C142046
Rabbit Polyclonal to Human TACR1 / NK1R
Rat, Human
Flo, IHC, IHC-P, WB
DY488 Conjugated
100µl  $365.00
Anti-Neurokinin 1 Receptor antibody IHC of human brain, putamen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Brain, Basal Nucleus of Meynert, Neurons 40X.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

TACR1 / NK1R Antibody (N-Terminus, DY550) LS-C142048
Rabbit Polyclonal to Human TACR1 / NK1R
Rat, Human
Flo, IHC, IHC-P, WB
DY550 Conjugated
100µl  $365.00
Anti-Neurokinin 1 Receptor antibody IHC of human brain, putamen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Brain, Basal Nucleus of Meynert, Neurons 40X.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ TACR1 / NK1R Antibody (C-Terminus) LS-A1341
Rabbit Polyclonal to Human TACR1 / NK1R
Rabbit, Guinea pig, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-Neurokinin 1 Receptor / NK1R antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1-40 ug/ml.
Anti-Neurokinin 1 Receptor / NK1R antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1-40 ug/ml.

IHC-plus™ TACR1 / NK1R Antibody (C-Terminus, Biotin) LS-A100963
Rabbit Polyclonal to Human TACR1 / NK1R
Rabbit, Guinea pig, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl 0.6mg/ml  $650.00
Anti-Neurokinin 1 Receptor / NK1R antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1-40 ug/ml.
Anti-Neurokinin 1 Receptor / NK1R antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1-40 ug/ml.

IHC-plus™ TACR1 / NK1R Antibody (C-Terminus, APC) LS-A100962
Rabbit Polyclonal to Human TACR1 / NK1R
Rabbit, Guinea pig, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
APC Conjugated
100µl  $650.00
Anti-Neurokinin 1 Receptor / NK1R antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1-40 ug/ml.
Anti-Neurokinin 1 Receptor / NK1R antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1-40 ug/ml.

IHC-plus™ TACR1 / NK1R Antibody (C-Terminus) LS-A1342
Rabbit Polyclonal to Human TACR1 / NK1R
Human, Monkey
IHC, IHC-P
Unconjugated
50µg 50µl 1mg/ml  $425.00
Anti-Neurokinin 1 Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

TACR1 / NK1R Antibody (C-Terminus) LS-C39306
Rabbit Polyclonal (IgG) to Rat TACR1 / NK1R
Mouse, Guinea pig, Rat
IHC, IHC-Fr
Unconjugated
100µl  $590.00

TACR1 / NK1R Antibody (aa231-245) LS-C312840
Rabbit Polyclonal to Human TACR1 / NK1R
Chicken, Sheep, Bovine, Rabbit, Mouse, Guinea pig, Rat, Horse, Bat, Human, Monkey
WB
Unconjugated
100µg 200µl 0.5mg/ml  $325.00
WB of TACR1 / NK1R antibody. Lane 1: A549 Cell Lysate. Lane 2: U87 Cell Lysate. Lane 3: COLO320 Cell Lysate. Lane 4: SCG Cell Lysate. Lane 5: PANC Cell Lysate.
Anti-TACR1 antibody, Western blotting All lanes: Anti TACR1 at 0.5ug/ml Lane 1: A549 Whole Cell Lysate at 40ug Lane 2: U87 Whole Cell Lysate at 40ug Lane 3: COLO320 Whole Cell Lysate at 40ug Lane 4: SCG Whole Cell Lysate at 40ug Lane 5: PANC Whole Cell Lysate at 40ug Predicted bind size: 45KD Observed bind size: 55KD

TACR1 / NK1R Antibody LS-C355710
Rabbit Polyclonal (IgG) to Human TACR1 / NK1R
Human, Chimpanzee
IF, IHC, IHC-P, WB
Unconjugated
100µl  $425.00
IHC using Neurokinin 1 Receptor Antibody
IHC using Neurokinin 1 Receptor Antibody

TACR1 / NK1R Antibody (180-260 aa, Internal) LS-C384913
Rabbit Polyclonal (IgG) to Human TACR1 / NK1R
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of NK-1R antibody

TACR1 / NK1R Antibody (FITC) LS-C211287
Rabbit Polyclonal (IgG) to Human TACR1 / NK1R
Human
ELISA, IHC, WB
FITC Conjugated
50µg  $285.00; 100µg 0.25mg/ml  $385.00

TACR1 / NK1R Antibody (C-Terminus) LS-C49198
Rabbit Polyclonal to Rat TACR1 / NK1R
Mouse, Guinea pig, Rat, Human
IHC, IHC-Fr
Unconjugated
100µl  $335.00
Confocal image of SPR reactivity using polyclonal anti-NK-1 Receptor in a lamina III neuron in the spinal cord of a rat.

TACR1 / NK1R Antibody LS-C809658
Rabbit Polyclonal (IgG) to Human TACR1 / NK1R
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00

TACR1 / NK1R Antibody (Internal) LS-C358357
Rabbit Polyclonal to Human TACR1 / NK1R
Chicken, Mouse, Dog, Rat, Human
ICC, IF, WB
Unconjugated
100µl 1mg/ml  $245.00
Western blot analysis of Tachykinin Receptor 1 expression in COLO205 (A); mouse brain (B) whole cell lysates.

TACR1 / NK1R Antibody LS-C809463
Rabbit Polyclonal (IgG) to Human TACR1 / NK1R
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Showing 1-25 of 63 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).