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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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TACR1 / NK1R

tachykinin receptor 1

Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing.

Gene Name: tachykinin receptor 1
Family/Subfamily: GPCR , Tachykinin
Synonyms: TACR1, Neurokinin receptor 1, NK-1R, Nk1 tachykinin receptor, NK1R, TAC1R, Tachykinin 1 receptor, NKIR, Substance-P receptor, Neurokinin 1 receptor, NK-1 receptor, Tachykinin receptor 1
Target Sequences: NM_001058 NP_001049.1 P25103

Publications (22)

1
Phosphorylated cAMP response element binding protein increases in neurokinin-1 receptor-immunoreactive neurons in rat spinal cord in response to formalin-induced nociception. Anderson LE, Seybold VS. Neuroscience letters. 2000 283:29-32. [PubMed:10729626]
2
Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex. Tooney PA, Au GG, Chahl LA. Neuroscience letters. 2000 283:185-8. (IHC; Human) [PubMed:10754218]
3
Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Setou M, Nakagawa T, Seog DH, Hirokawa N. Science (New York, N.Y.). 2000 288:1796-802. [PubMed:10846156]
4
Localization of NK1 and NK3 receptors in guinea-pig brain. Yip J, Chahl LA. Regulatory peptides. 2001 98:55-62. [PubMed:11179779]
5
Increased tachykinin NK(1) receptor immunoreactivity in the prefrontal cortex in schizophrenia. Tooney PA, Crawter VC, Chahl LA. Biological psychiatry. 2001 49:523-7. (IHC; Human) [PubMed:11257237]
6
NK-1 receptor gene expression is related to pain in chronic pancreatitis. Shrikhande SV, Friess H, di Mola FF, Tempia-Caliera A, Conejo Garcia JR, Zhu Z, Zimmermann A, Bchler MW. Pain. 2001 91:209-17. (IHC; Human) [PubMed:11275376]
7
Temporal decrease in renal sensory responses in rats after chronic ligation of the bile duct. Ma MC, Huang HS, Chien CT, Wu MS, Chen CF. American journal of physiology. Renal physiology. 2002 283:F164-72. [PubMed:12060598]
8
The expression of neurokinin-1 receptor at striatal and pallidal levels in normal human brain. Mounir S, Parent A. Neuroscience research. 2002 44:71-81. [PubMed:12204295]
9
Paraventricular vasopressin-containing neurons project to brain stem and spinal cord respiratory-related sites. Kc P, Haxhiu MA, Tolentino-Silva FP, Wu M, Trouth CO, Mack SO. Respiratory Physiology & Neurobiology. 2002 133:75-88. [PubMed:12385733]
10
A neurochemically distinct dorsal raphe-limbic circuit with a potential role in affective disorders. Commons KG, Connolley KR, Valentino RJ. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2003 28:206-15. [PubMed:12589373]
11
Depletion of ventromedullary NK-1 receptor-immunoreactive neurons in multiple system atrophy. Benarroch EE, Schmeichel AM, Low PA, Parisi JE. Brain : a journal of neurology. 2003 126:2183-90. (IHC; Human) [PubMed:12902309]
12
Full-length and truncated neurokinin-1 receptor expression and function during monocyte/macrophage differentiation. Lai JP, Ho WZ, Kilpatrick LE, Wang X, Tuluc F, Korchak HM, Douglas SD. Proceedings of the National Academy of Sciences of the United States of America. 2006 103:7771-6. (ICC; Human) [PubMed:16675550] [PMC:PMC1457089]
13
Expression of NK-1 and NK-3 tachykinin receptors in pancreatic acinar cells after acute experimental pancreatitis in rats. Broccardo M, Linari G, Agostini S, Amadoro G, Carpino F, Ciotti MT, Petrella C, Petrozza V, Severini C, Improta G. American journal of physiology. Gastrointestinal and liver physiology. 2006 291:G518-24. [PubMed:16782701]
14
Neurokinin-1 receptor activation in Botzinger complex evokes bradypnoea. Fong AY, Potts JT. The Journal of physiology. 2006 575:869-85. (IHC; Rat) [PubMed:16825299] [PMC:PMC1995693]
15
Spantide I decreases type I cytokines, enhances IL-10, and reduces corneal perforation in susceptible mice after Pseudomonas aeruginosa infection. Hazlett LD, McClellan SA, Barrett RP, Liu J, Zhang Y, Lighvani S. Investigative ophthalmology & visual science. 2007 48:797-807. (IHC; Mouse) [PubMed:17251480]
16
cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. Schmidtko A, Gao W, Knig P, Heine S, Motterlini R, Ruth P, Schlossmann J, Koesling D, Niederberger E, Tegeder I, Friebe A, Geisslinger G. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 28:8568-76. (IHC; Mouse) [PubMed:18716216]
17
Cardiac damage after lesions of the nucleus tractus solitarii. Nayate A, Moore SA, Weiss R, Taktakishvili OM, Lin LH, Talman WT. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 296:R272-9. (IHC; Rat) [PubMed:19020288] [PMC:PMC2643979]
18
Substance P receptor activation induces downregulation of the AMPA receptor functionality in cortical neurons from a genetic model of Amyotrophic Lateral Sclerosis. Caioli S, Curcio L, Pieri M, Antonini A, Marolda R, Severini C, Zona C. Neurobiology of disease. 2011 44:92-101. [PubMed:21726643]
19
Kinetics of neuronal contribution during the development of a contact allergic reaction. Altawil R, Lystrm J, El-Nour H. Archives of dermatological research. 2012 304:273-81. (IHC; Human) [PubMed:22198823]
20
Substance P alterations in skin and brain of chronically stressed atopic-like mice. Grip L, Lonne-Rahm SB, Holst M, Johansson B, Nordlind K, Theodorsson E, El-Nour H. Journal of the European Academy of Dermatology and Venereology : JEADV. 2013 27:199-205. (ICC, IHC; Mouse) [PubMed:22251186]
21
Visceral hypersensitivity in symptomatic diverticular disease and the role of neuropeptides and low grade inflammation. Humes DJ, Simpson J, Smith J, Sutton P, Zaitoun A, Bush D, Bennett A, Scholefield JH, Spiller RC. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2012 24:318-e163. (IHC; Human) [PubMed:22276853]
22
Sudden death and myocardial lesions after damage to catecholamine neurons of the nucleus tractus solitarii in rat. Talman WT, Dragon DN, Jones SY, Moore SA, Lin LH. Cellular and molecular neurobiology. 2012 32:1119-26. (ICC, IHC-Fr; Rat) [PubMed:22484855]
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TACR1 / NK1R (63)
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No (63)
TACR1 / NK1R Antibody - Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Neuroscience
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TACR1 / NK1R Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Dog, Bovine, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$425
TACR1 / NK1R Antibody - Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (Extracellular Domain) (Biotin) Antibody
Dog, Bovine, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100 µl/$650
TACR1 / NK1R Antibody - Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (Extracellular Domain) (FITC) Antibody
Dog, Bovine, Human, Monkey
IHC, IHC-P
FITC Conjugated
100 µl/$650
TACR1 / NK1R Antibody - Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (Extracellular Domain) (APC) Antibody
Dog, Bovine, Human, Monkey
IHC, IHC-P
APC Conjugated
100 µl/$650
TACR1 / NK1R Antibody - Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (Extracellular Domain) (AP) Antibody
Dog, Bovine, Human, Monkey
IHC, IHC-P
AP Conjugated
100 µl/$650
TACR1 / NK1R Antibody - Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (Extracellular Domain) (Azide-free) (HRP) Antibody
Dog, Bovine, Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100 µl/$650
TACR1 / NK1R Antibody - Anti-TACR1 /  NK1R antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (Extracellular Domain) (PE) Antibody
Dog, Bovine, Human, Monkey
IHC, IHC-P
PE Conjugated
100 µl/$650
TACR1 / NK1R Antibody - Anti-Neurokinin 1 Receptor / NK1R antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1-40 ug/ml.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Guinea pig, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$425
TACR1 / NK1R Antibody - Anti-Neurokinin 1 Receptor / NK1R antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1-40 ug/ml.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Rabbit, Guinea pig, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
Biotin Conjugated
100 µl/$650
TACR1 / NK1R Antibody - Anti-Neurokinin 1 Receptor / NK1R antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1-40 ug/ml.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Rabbit, Guinea pig, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
FITC Conjugated
100 µl/$650
TACR1 / NK1R Antibody - Anti-Neurokinin 1 Receptor / NK1R antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1-40 ug/ml.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (C-Terminus) (AP) Antibody
Rabbit, Guinea pig, Rat, Hamster, Horse, Human, Monkey
IHC, IHC-P
AP Conjugated
100 µl/$650
TACR1 / NK1R Antibody - Anti-Neurokinin 1 Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$425
TACR1 / NK1R Antibody - Anti-Neurokinin 1 Receptor antibody IHC of human brain, putamen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
100 µl/$425
TACR1 / NK1R Antibody - Anti-Neurokinin 1 Receptor antibody IHC of human brain, putamen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Rat, Human
Flo, IHC, IHC-P, WB
Biotin Conjugated
100 µl/$365
TACR1 / NK1R Antibody - Anti-Neurokinin 1 Receptor antibody IHC of human brain, putamen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (N-Terminus) (DY488) Antibody
Rat, Human
Flo, IHC, IHC-P, WB
DY488 Conjugated
100 µl/$365
TACR1 / NK1R Antibody - Anti-Neurokinin 1 Receptor antibody IHC of human brain, putamen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (N-Terminus) (DY650) Antibody
Rat, Human
Flo, IHC, IHC-P, WB
DY650 Conjugated
100 µl/$365
TACR1 / NK1R Antibody - Anti-Neurokinin 1 Receptor antibody IHC of human brain, putamen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (N-Terminus) (DY550) Antibody
Rat, Human
Flo, IHC, IHC-P, WB
DY550 Conjugated
100 µl/$365
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TACR1 / NK1R Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Guinea pig, Rat
IHC, IHC-Fr
Unconjugated
100 µl/$590
TACR1 / NK1R Antibody - WB of TACR1 / NK1R antibody. Lane 1: A549 Cell Lysate. Lane 2: U87 Cell Lysate. Lane 3: COLO320 Cell Lysate. Lane 4: SCG Cell Lysate. Lane 5: PANC Cell Lysate.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (aa231-245) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Guinea pig, Rat, Horse, Bat, Human, Monkey
WB
Unconjugated
100 µg/$325
TACR1 / NK1R Antibody - Western blot of NK-1R antibody
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TACR1 / NK1R Rabbit anti-Human Polyclonal (180-260 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
50 µl/$235; 100 µl/$265; 200 µl/$335
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TACR1 / NK1R Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$285; 100 µg/$385
TACR1 / NK1R Antibody - Confocal image of SPR reactivity using polyclonal anti-NK-1 Receptor in a lamina III neuron in the spinal cord of a rat.
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TACR1 / NK1R Rabbit anti-Rat Polyclonal (C-Terminus) Antibody
Mouse, Guinea pig, Rat, Human
IHC, IHC-Fr
Unconjugated
100 µl/$335
TACR1 / NK1R Antibody - 1:100 staining human liver carcinoma tissues by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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TACR1 / NK1R Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$325; 200 µl/$375
TACR1 / NK1R Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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TACR1 / NK1R Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µl/$325; 200 µl/$375
TACR1 / NK1R Antibody - Western blot analysis of Tachykinin Receptor 1 expression in COLO205 (A); mouse brain (B) whole cell lysates.
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TACR1 / NK1R Rabbit anti-Human Polyclonal (Internal) Antibody
Chicken, Mouse, Dog, Rat, Human
ICC, IF, WB
Unconjugated
100 µl/$245
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).