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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SUMO1 / SMT3

small ubiquitin-like modifier 1

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.

Gene Name: small ubiquitin-like modifier 1
Synonyms: SUMO1, GAP modifying protein 1, GMP1, OFC10, Sentrin, SMT3 homolog 3, SMT3C, SMT3H3, SUMO-1, Ubiquitin-like protein UBL1, PIC1, Ubiquitin-like 1 (sentrin), UBL1, DAP1, GAP-modifying protein 1, Ubiquitin-like protein SMT3C
Target Sequences: NM_003352 NP_003343.1 P63165

Publications (4)

1
SUMO modification of the Ets-related transcription factor ERM inhibits its transcriptional activity. Degerny C, Monte D, Beaudoin C, Jaffray E, Portois L, Hay RT, de Launoit Y, Baert JL. The Journal of biological chemistry. 2005 280:24330-8. [PubMed:15857832] Related Antibodies: LS-C161612.
2
SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7. Janer A, Werner A, Takahashi-Fujigasaki J, Daret A, Fujigasaki H, Takada K, Duyckaerts C, Brice A, Dejean A, Sittler A. Human molecular genetics. 2010 19:181-95. [PubMed:19843541]
3
Insights into high affinity small ubiquitin-like modifier (SUMO) recognition by SUMO-interacting motifs (SIMs) revealed by a combination of NMR and peptide array analysis. Namanja AT, Li YJ, Su Y, Wong S, Lu J, Colson LT, Wu C, Li SS, Chen Y. The Journal of biological chemistry. 2012 287:3231-40. [PubMed:22147707] [PMC:PMC3270977] Related Antibodies: LS-C96460.
4
Transition from a nucleosome-based to a protamine-based chromatin configuration during spermiogenesis in Drosophila. Rathke C, Baarends WM, Jayaramaiah-Raja S, Bartkuhn M, Renkawitz R, Renkawitz-Pohl R. Journal of cell science. 2007 120:1689-700. [PubMed:17452629] Related Antibodies: LS-C98764.
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Filtered By: None
Target
SUMO1 / SMT3 (113)
Reactivity
Human (110)
Mouse (40)
Rat (40)
Bat (5)
Bovine (8)
Chicken (3)
Chimpanzee (3)
Dog (7)
Guinea pig (5)
Horse (7)
Monkey (8)
Orangutan (3)
Pig (6)
Rabbit (7)
Sheep (1)
Yeast (1)
Application
IHC (72)
IHC-Fr (1)
IHC-P (22)
WB (101)
Flo (30)
ChIP-Seq (1)
ELISA (55)
ICC (19)
IF (47)
IP (6)
Peptide-ELISA (1)
RIA (1)
Host
rabbit (74)
mouse (37)
goat (1)
sheep (1)
Isotype
Ig (1)
IgG (51)
IgG1 (9)
IgG1,k (26)
IgG2a,k (1)
IgG3 (1)
Clonality
monoclonal mc (38)
polyclonal pc (75)
Clone
3D7 (1)
5B12 (1)
66AT1273.94 (1)
S1MT-2 (3)
SM1/495 (3)
SPM571 (3)
SUMO1/1188 (3)
Format
AP Conjugated (7)
APC (1)
APC Conjugated (7)
Azide-free (8)
Biotin Conjugated (10)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (10)
HRP Conjugated (9)
PE Conjugated (8)
Ready-to-Use (4)
Unconjugated (60)
Epitope
aa1-101 (10)
N-Terminus (8)
aa55-86 (8)
aa1-30 (7)
aa6-21 (2)
1-80 aa, N-terminal (1)
Asp86, C-Terminal (1)
C-Terminus (1)
Ser2 (1)
aa1-50 (1)
aa15-30 (1)
aa2-101 (1)
Publications
No (110)
Yes (3)
Showing 1-25 of 113 results

SUMO1 / SMT3 Antibody (N-Terminus) IHC-plus™ LS-B594
Rabbit Polyclonal (IgG) to Human SUMO1 / SMT3
Mouse, Rat, Human
ICC IF IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-SUMO1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-SUMO1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-SUMO1 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Anti-SUMO1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

SUMO1 / SMT3 Antibody LS-C161612
Publications (1)
Publications (1)
Rabbit Polyclonal to Human SUMO1 / SMT3
Human
Flo IF IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human brain tissue reacted with SUMO1 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Confocal immunofluorescence of SUMO1 Antibody with A375 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).
Formalin-fixed and paraffin-embedded human brain tissue reacted with SUMO1 Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Confocal immunofluorescence of SUMO1 Antibody with A375 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). Actin filaments have been labeled with Alexa Fluor 555 phalloidin (red). DAPI was used to stain the cell nuclear (blue).

SUMO1 / SMT3 Antibody (aa55-86) LS-C98764
Publications (1)
Publications (1)
Rabbit Polyclonal to Human SUMO1 / SMT3
Human
Flo IHC IHC-P WB
Unconjugated
400µl  $305.00
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
The anti-SUMO1 polyclonal antibody is used in Western blot to detect GST-SUMO1 fusion protein.
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
The anti-SUMO1 polyclonal antibody is used in Western blot to detect GST-SUMO1 fusion protein.

SUMO1 / SMT3 Antibody (clone 66AT1273.94) LS-C96460
Publications (1)
Publications (1)
Mouse Monoclonal [clone 66AT1273.94] (IgG1) to Human SUMO1 / SMT3
Human
WB
Unconjugated
400µl  $305.00
The SUMO1 monoclonal antibody is used in Western blot to detect SUMO1 in HL60 cell lysate.
The SUMO1 monoclonal antibody is used in Western blot to detect SUMO1 in HL60 cell lysate.

SUMO1 / SMT3 Antibody LS-C497818
Rabbit Monoclonal to Human SUMO1 / SMT3
Mouse, Rat, Human
ChIP-Seq Flo IF IHC IP WB
Unconjugated
50µl  $295.00; 100µl  $385.00; 200µl  $560.00
Immunohistochemistry of paraffin-embedded mouse placenta using SUMO1 antibodyat dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human mammary cancer using SUMO1 antibodyat dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded mouse placenta using SUMO1 antibodyat dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human mammary cancer using SUMO1 antibodyat dilution of 1:100 (40x lens).

SUMO1 / SMT3 Antibody (aa1-50) IHC-plus™ LS-B7650
Rabbit Polyclonal (IgG) to Human SUMO1 / SMT3
Mouse, Rat, Human
IF IHC IHC-P Peptide-ELISA WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-SUMO1 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Immunofluorescence analysis of NIH/3T3 cells, using Sumo1 Antibody. The picture on the right is blocked with the synthesized peptide.
Anti-SUMO1 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Immunofluorescence analysis of NIH/3T3 cells, using Sumo1 Antibody. The picture on the right is blocked with the synthesized peptide.

SUMO1 / SMT3 Antibody LS-C15472
Mouse Monoclonal (IgG1,k) to Human SUMO1 / SMT3
Mouse, Rat, Human
ELISA IF WB
Unconjugated
100µg 0.5mg/ml  $605.00

SUMO1 / SMT3 Antibody (clone 5B12) LS-C179834
Mouse Monoclonal [clone 5B12] (IgG1) to Human SUMO1 / SMT3
Mouse, Rat, Human
ICC WB
Unconjugated
100µg 1mg/ml  $345.00
Western blot Image
Western blot Image

SUMO1 / SMT3 Antibody (clone SUMO1/1188) LS-C391106
Mouse Monoclonal [clone SUMO1/1188] (IgG1,k) to Human SUMO1 / SMT3
Rat, Human
Flo IF IHC IHC-P WB
Unconjugated
20µg 0.2mg/ml  $255.00; 100µg  $395.00
Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with SUMO-1 antibody (SUMO1/1188).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human testicular carcinoma stained with SUMO-1 antibody (SUMO1/1188).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with SUMO-1 antibody (SUMO1/1188).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human testicular carcinoma stained with SUMO-1 antibody (SUMO1/1188).  This image was taken for the unmodified form of this product. Other forms have not been tested.

SUMO1 / SMT3 Antibody (clone SUMO1/1188, Azide-free) LS-C391104
Mouse Monoclonal [clone SUMO1/1188] (IgG1,k) to Human SUMO1 / SMT3
Rat, Human
Flo IF IHC IHC-P WB
Unconjugated, Azide-free
100µg 1mg/ml  $415.00
Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with SUMO-1 antibody (SUMO1/1188).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human testicular carcinoma stained with SUMO-1 antibody (SUMO1/1188).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with SUMO-1 antibody (SUMO1/1188).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human testicular carcinoma stained with SUMO-1 antibody (SUMO1/1188).  This image was taken for the unmodified form of this product. Other forms have not been tested.

SUMO1 / SMT3 Antibody (clone SUMO1/1188, Ready-to-Use) LS-C391105
Mouse Monoclonal [clone SUMO1/1188] (IgG1,k) to Human SUMO1 / SMT3
Rat, Human
Flo IF IHC IHC-P WB
Unconjugated, Ready-to-Use
7000µl  $395.00
Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with SUMO-1 antibody (SUMO1/1188).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human testicular carcinoma stained with SUMO-1 antibody (SUMO1/1188).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with SUMO-1 antibody (SUMO1/1188).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human testicular carcinoma stained with SUMO-1 antibody (SUMO1/1188).  This image was taken for the unmodified form of this product. Other forms have not been tested.

SUMO1 / SMT3 Antibody (clone S1MT-2) LS-C391855
Mouse Monoclonal [clone S1MT-2] (IgG1,k) to Human SUMO1 / SMT3
Mouse, Rat, Human
Flo IF IHC IHC-P WB
Unconjugated
20µg 0.2mg/ml  $255.00; 100µg  $395.00
IHC staining of human tonsil with SUMO1 antibody (clone S1MT-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
IHC staining of rat pancreas with SUMO1 antibody (clone S1MT-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
IHC staining of human tonsil with SUMO1 antibody (clone S1MT-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
IHC staining of rat pancreas with SUMO1 antibody (clone S1MT-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.

SUMO1 / SMT3 Antibody (clone S1MT-2, Azide-free) LS-C391859
Mouse Monoclonal [clone S1MT-2] (IgG1,k) to Human SUMO1 / SMT3
Mouse, Rat, Human
Flo IF IHC IHC-P WB
Unconjugated, Azide-free
100µg 1mg/ml  $415.00
IHC staining of human tonsil with SUMO1 antibody (clone S1MT-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
IHC staining of rat pancreas with SUMO1 antibody (clone S1MT-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
IHC staining of human tonsil with SUMO1 antibody (clone S1MT-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
IHC staining of rat pancreas with SUMO1 antibody (clone S1MT-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.

SUMO1 / SMT3 Antibody (clone S1MT-2, Ready-to-Use) LS-C391857
Mouse Monoclonal [clone S1MT-2] (IgG1,k) to Human SUMO1 / SMT3
Mouse, Rat, Human
Flo IF IHC IHC-P WB
Unconjugated, Ready-to-Use
7000µl  $395.00
IHC staining of human tonsil with SUMO1 antibody (clone S1MT-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
IHC staining of rat pancreas with SUMO1 antibody (clone S1MT-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
IHC staining of human tonsil with SUMO1 antibody (clone S1MT-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
IHC staining of rat pancreas with SUMO1 antibody (clone S1MT-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.

SUMO1 / SMT3 Antibody (clone SM1/495) LS-C358055
Mouse Monoclonal [clone SM1/495] (IgG1,k) to Human SUMO1 / SMT3
Human
ELISA Flo IF IHC IHC-P IP WB
Unconjugated
20µg  $255.00; 100µg  $395.00
SUMO1 antibody SM1/495 immunohistochemistry tonsil.  This image was taken for the unmodified form of this product. Other forms have not been tested.
SUMO1 antibody SM1/495 western blot.  This image was taken for the unmodified form of this product. Other forms have not been tested.
SUMO1 antibody SM1/495 immunohistochemistry tonsil.  This image was taken for the unmodified form of this product. Other forms have not been tested.
SUMO1 antibody SM1/495 western blot.  This image was taken for the unmodified form of this product. Other forms have not been tested.

SUMO1 / SMT3 Antibody (clone SM1/495, Azide-free) LS-C389746
Mouse Monoclonal [clone SM1/495] (IgG1,k) to Human SUMO1 / SMT3
Human
ELISA Flo IF IHC IHC-P IP WB
Unconjugated, Azide-free
100µg 1mg/ml  $415.00
SUMO1 antibody SM1/495 immunohistochemistry tonsil.  This image was taken for the unmodified form of this product. Other forms have not been tested.
SUMO1 antibody SM1/495 western blot.  This image was taken for the unmodified form of this product. Other forms have not been tested.
SUMO1 antibody SM1/495 immunohistochemistry tonsil.  This image was taken for the unmodified form of this product. Other forms have not been tested.
SUMO1 antibody SM1/495 western blot.  This image was taken for the unmodified form of this product. Other forms have not been tested.

SUMO1 / SMT3 Antibody (clone SM1/495, Ready-to-Use) LS-C389729
Mouse Monoclonal [clone SM1/495] (IgG1,k) to Human SUMO1 / SMT3
Human
ELISA Flo IF IHC IHC-P IP WB
Unconjugated, Ready-to-Use
7000µl  $395.00
SUMO1 antibody SM1/495 immunohistochemistry tonsil.  This image was taken for the unmodified form of this product. Other forms have not been tested.
SUMO1 antibody SM1/495 western blot.  This image was taken for the unmodified form of this product. Other forms have not been tested.
SUMO1 antibody SM1/495 immunohistochemistry tonsil.  This image was taken for the unmodified form of this product. Other forms have not been tested.
SUMO1 antibody SM1/495 western blot.  This image was taken for the unmodified form of this product. Other forms have not been tested.

SUMO1 / SMT3 Antibody (Biotin) LS-C270693
Rabbit Polyclonal (IgG) to Human SUMO1 / SMT3
Human
ELISA Flo ICC IF IHC WB
Biotin Conjugated
200µl  $680.00

SUMO1 / SMT3 Antibody (FITC) LS-C270695
Rabbit Polyclonal (IgG) to Human SUMO1 / SMT3
Human
ELISA Flo ICC IF IHC WB
FITC Conjugated
200µl  $680.00

SUMO1 / SMT3 Antibody (AP) LS-C270691
Rabbit Polyclonal (IgG) to Human SUMO1 / SMT3
Human
ELISA Flo ICC IF IHC WB
AP Conjugated
200µl  $680.00

SUMO1 / SMT3 Antibody (Azide-free, HRP) LS-C270694
Rabbit Polyclonal (IgG) to Human SUMO1 / SMT3
Human
ELISA Flo ICC IF IHC WB
HRP Conjugated, Azide-free
200µl  $680.00

SUMO1 / SMT3 Antibody (APC) LS-C270692
Rabbit Polyclonal (IgG) to Human SUMO1 / SMT3
Human
ELISA Flo ICC IF IHC WB
APC Conjugated
200µl  $680.00

SUMO1 / SMT3 Antibody (aa55-86, Biotin) LS-C270699
Rabbit Polyclonal (IgG) to Human SUMO1 / SMT3
Human
ELISA Flo ICC IF IHC WB
Biotin Conjugated
200µl  $680.00

SUMO1 / SMT3 Antibody (aa55-86, AP) LS-C270697
Rabbit Polyclonal (IgG) to Human SUMO1 / SMT3
Human
ELISA Flo ICC IF IHC WB
AP Conjugated
200µl  $680.00

SUMO1 / SMT3 Antibody (aa55-86, APC) LS-C270698
Rabbit Polyclonal (IgG) to Human SUMO1 / SMT3
Human
ELISA Flo ICC IF IHC WB
APC Conjugated
200µl  $680.00
Showing 1-25 of 113 results

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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