STK39 / SPAK is a serine/threonine kinase that is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress.
|Gene Name:||serine threonine kinase 39|
|Family/Subfamily:||Protein Kinase , FRAY|
|Synonyms:||STK39, Serine threonine kinase 39, STE20/SPS1 homolog, Ste20-like protein kinase, DCHT, SPAK, Ste-20-related kinase|
|Target Sequences:||NM_013233 NP_037365.2 Q9UEW8|
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