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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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SPHK / SPHK1

sphingosine kinase 1

SPHK / SPHK1 catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: sphingosine kinase 1
Family/Subfamily: Non-protein Kinase , Sphingosine
Synonyms: SPHK1, SK1, Sphingosine kinase 1, SPHK, SK 1, SPK 1, Sphingosine kinase type 1, SPK
Target Sequences: NM_021972 NP_068807.2 Q9NYA1

Publications (1)

1
Sphingosine kinase 1 and sphingosine 1-phosphate receptor 3 are functionally upregulated on astrocytes under pro-inflammatory conditions. Fischer I, Alliod C, Martinier N, Newcombe J, Brana C, Pouly S. PloS one. 2011 6:e23905. [PubMed:21887342] [PMC:PMC3161076] Related Antibodies: LS-C100769.

Viewing 1-25 of 81 items
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, pheochromocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, pheochromocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, pheochromocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, pheochromocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, pheochromocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, pheochromocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, pheochromocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human SPHK / SPHK1
Mouse, Hamster, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
1ea   $425.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, zona glomerulosa. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Rabbit Polyclonal to Human SPHK / SPHK1
Human
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, zona glomerulosa. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, zona glomerulosa. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human
IHC, IHC-P
FITC Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, zona glomerulosa. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human
IHC, IHC-P
PE Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, zona glomerulosa. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human
IHC, IHC-P
AP Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, zona glomerulosa. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human
IHC, IHC-P
APC Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human adrenal, zona glomerulosa. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
Unconjugated
50µg   50µl   1mg/ml   $425.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
Biotin Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
FITC Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
AP Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
APC Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
PE Conjugated
100µl   $650.00
SPHK / SPHK1 Antibody - Anti-SPHK1 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Select
Fast Shipping
Rabbit Polyclonal to Human SPHK / SPHK1
Human, Monkey
IHC, IHC-P
HRP Conjugated, Azide-free
100µl   $650.00
SPHK / SPHK1 Antibody - Western blot of anti-mouse SphK1 (pS225) (phospho-Sphingosine Kinase 1,(pS225), Mouse reactive) on mouse B-cell lysate. Antibody used at 1 ug/ml with phosphorylated blocking peptideNo. X1877B) (lane A) and without (lane B).
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Rabbit Polyclonal to Mouse SPHK / SPHK1
Mouse
WB
Unconjugated
100µg   0.5mg/ml   $495.00
SPHK / SPHK1 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Rabbit Polyclonal to Human SPHK / SPHK1
Mouse, Rat, Primate, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
SPHK / SPHK1 Antibody - Antibody (2 ug/ml) staining of Human Peripheral Blood Mononucleocyte lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence
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Goat Polyclonal to Human SPHK / SPHK1
Mouse, Hamster, Human, Monkey
IP, Peptide-ELISA, WB
Unconjugated
100µg   0.5mg/ml   $405.00

Viewing 1-25 of 81 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).