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Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
Gene Name: | synuclein, alpha (non A4 component of amyloid precursor) |
Synonyms: | SNCA, Alpha-synuclein, PARK4, PD1, Synuclein alpha-140, NACP, PARK1, aSynuclein, a-Synuclein |
Target Sequences: | NM_000345 NP_000336.1 P37840 |
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