Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
SLC1A2 / EAAT2 / GLT-1 is a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified.
|Gene Name:||solute carrier family 1 (glial high affinity glutamate transporter), member 2|
|Family/Subfamily:||Transporter , Sodium:dicarboxylate symporter|
|Synonyms:||SLC1A2, EAAT-2, GLT-1, Glutamate transporter 1, EAAT2, GLT1|
|Target Sequences:||NM_004171 NP_004162.2 P43004|
If you do not find the reagent or information you require, please contact firstname.lastname@example.org to inquire about additional products in development.