Products
Services
Research Areas
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Reasearch Areas
Cell Cycle Pathways
Protein Family And Group
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.

Gene Name: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Family/Subfamily: Toll-like Receptor
Synonyms: SIGIRR, TIR8, Toll/interleukin-1 receptor 8
Target Sequences: NM_021805 NP_068577.2 Q6IA17

Filtered by: None
Target
SIGIRR (45)
Reactivity
Human (28)
Mouse (21)
Rat (13)
Bovine (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (4)
Horse (4)
Monkey (4)
Pig (8)
Zebrafish (4)
Application
IHC (11)
IHC-Fr (2)
IHC-P (6)
WB (39)
Flo (3)
ELISA (5)
Host
rabbit (44)
mouse (1)
Isotype
IgG (14)
IgG2a (1)
Clonality
monoclonal mc (1)
polyclonal pc (44)
Format
AP Conjugated (1)
APC (3)
APC Conjugated (4)
Biotin Conjugated (5)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (5)
Unconjugated (14)
Epitope
aa1-118 (16)
aa1-117 (8)
C-Terminus (6)
aa309-323 (1)
aa334-358 (1)
Publications
No (45)
Showing 1-25 of 45 results

IHC-plus™ SIGIRR Antibody (C-Terminus) LS-B5817
Rabbit Polyclonal (IgG) to Human SIGIRR
Zebrafish, Horse, Rat, Mouse, Dog, Guinea pig, Bovine, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-SIGIRR antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SIGIRR antibody Western blot of Jurkat lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

SIGIRR Antibody (C-Terminus, HRP) LS-C452473
Rabbit Polyclonal (IgG) to Human SIGIRR
Zebrafish, Horse, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Anti-SIGIRR antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SIGIRR antibody Western blot of Jurkat lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

SIGIRR Antibody (C-Terminus, Biotin) LS-C452676
Rabbit Polyclonal (IgG) to Human SIGIRR
Zebrafish, Horse, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Anti-SIGIRR antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SIGIRR antibody Western blot of Jurkat lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

SIGIRR Antibody (C-Terminus, FITC) LS-C452472
Rabbit Polyclonal (IgG) to Human SIGIRR
Zebrafish, Horse, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100µl 1mg/ml  $385.00
Anti-SIGIRR antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
SIGIRR antibody Western blot of Jurkat lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

SIGIRR Antibody (APC) LS-C132109
Mouse Monoclonal (IgG2a) to Human SIGIRR
Human
Flo
APC Conjugated
100tst  $755.00

SIGIRR Antibody (aa1-117) LS-C296440
Rabbit Polyclonal to Mouse SIGIRR
Mouse
WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $275.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $590.00
Western blot of recombinant SIGIRR.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SIGIRR Antibody (aa1-117, HRP) LS-C714592
Rabbit Polyclonal to Mouse SIGIRR
Mouse
WB
HRP Conjugated
100µl 0.5mg/ml  $305.00; 200µl 0.5mg/ml  $365.00; 1ml 0.5mg/ml  $770.00
Western blot of recombinant SIGIRR.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SIGIRR Antibody (aa1-117, FITC) LS-C696600
Rabbit Polyclonal to Mouse SIGIRR
Mouse
WB
FITC Conjugated
100µl 0.5mg/ml  $295.00; 200µl 0.5mg/ml  $355.00; 1ml 0.5mg/ml  $710.00
Western blot of recombinant SIGIRR.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

SIGIRR Antibody LS-C676488
Rabbit Polyclonal (IgG) to Human SIGIRR
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl  $235.00; 100µl  $285.00
Immunohistochemistry of paraffin-embedded human adrenal gland tissue at dilution 1:100
Immunohistochemistry of paraffin-embedded human liver cancer at dilution 1:100

SIGIRR Antibody (C-Terminus) LS-C124546
Rabbit Polyclonal (IgG) to Mouse SIGIRR
Mouse, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µg  $575.00

SIGIRR Antibody (HRP) LS-C549465
Rabbit Polyclonal (IgG) to Mouse SIGIRR
Mouse, Human
IHC, WB
HRP Conjugated
100µl  $755.00

SIGIRR Antibody (Biotin) LS-C529378
Rabbit Polyclonal (IgG) to Mouse SIGIRR
Mouse, Human
IHC, WB
Biotin Conjugated
100µl  $755.00

SIGIRR Antibody (FITC) LS-C539299
Rabbit Polyclonal (IgG) to Mouse SIGIRR
Mouse, Human
IHC, WB
FITC Conjugated
100µl  $755.00

SIGIRR Antibody (AP) LS-C511283
Rabbit Polyclonal (IgG) to Mouse SIGIRR
Mouse, Human
IHC, WB
AP Conjugated
100µl  $755.00

SIGIRR Antibody (PE) LS-C657445
Rabbit Polyclonal (IgG) to Mouse SIGIRR
Mouse, Human
IHC, WB
PE Conjugated
100µl  $755.00

SIGIRR Antibody LS-C779202
Rabbit Polyclonal to Human SIGIRR
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg 100µl 1mg/ml  $305.00

SIGIRR Antibody (C-Terminus) LS-C187825
Rabbit Polyclonal (IgG) to Mouse SIGIRR
Mouse
IHC-Fr, WB
Unconjugated
50µg  $265.00; 100µg 1mg/ml  $355.00
Immunohistochemistry of A549 cells with Rabbit anti-Mouse SIGIRR
Western blot of whole cell lysate from A549 human lung adenocarcinoma cells probed with Rabbit anti-Mouse SIGIRR at 0.5(A), 1(B) and 2(C) ug/ml

SIGIRR Antibody LS-C489282
Rabbit Polyclonal to Human SIGIRR
Human
Flo
Unconjugated
50µl  $275.00; 100µl  $355.00

SIGIRR Antibody LS-C489283
Rabbit Polyclonal to Human SIGIRR
Human
ELISA
Unconjugated
100µl  $255.00; 200µl  $305.00; 400µl  $355.00

SIGIRR Antibody LS-C489284
Rabbit Polyclonal to Human SIGIRR
Human
ELISA
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

SIGIRR Antibody LS-C489285
Rabbit Polyclonal to Human SIGIRR
Human
ELISA
Unconjugated
50µl  $275.00; 100µl  $355.00

SIGIRR Antibody (aa309-323) LS-C798
Rabbit Polyclonal (IgG) to Human SIGIRR
Human
WB
Unconjugated
200µl  $335.00
Western blot of SIGIRR in40 ugs of A) HCT-116 and B) A549cell lysate using antibody at 1:500 dilution.

SIGIRR Antibody (aa334-358) LS-C816
Rabbit Polyclonal (IgG) to Human SIGIRR
Mouse, Human
WB
Unconjugated
100µg 200µl 0.5mg/ml  $335.00
Western blot of human TIR8 in 15 ugs of (A) human kidney and (B) mouse kidney cell lysate using antibody at 0.5 ug/ml.

SIGIRR Antibody (aa1-118) LS-C296437
Rabbit Polyclonal to Human SIGIRR
Pig, Human
WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $575.00
Western blot Image
Western blot Image

SIGIRR Antibody (PE) LS-C489280
Rabbit Polyclonal to Human SIGIRR
Human
Flo
PE Conjugated
25tst  $265.00; 50tst  $295.00; 100tst  $365.00
Showing 1-25 of 45 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).