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SIGIRR

single immunoglobulin and toll-interleukin 1 receptor (TIR) domain

SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.

Gene Name: single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
Family/Subfamily: Toll-like Receptor
Synonyms: SIGIRR, TIR8, Toll/interleukin-1 receptor 8
Target Sequences: NM_021805 NP_068577.2 Q6IA17

☰ Filters
Antibodies (46)
cDNAs (39)
Proteins (19)
cDNA Clone (3)
Expression-Ready ORF Clone (36)
Over-Expression Lysate (6)
Primary (46)
Recombinant (13)
SIGIRR (104)
Human (28)
Mouse (22)
Rat (14)
Bovine (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (4)
Horse (4)
Monkey (4)
Pig (8)
Zebrafish (4)
IHC (11)
IHC-Fr (2)
IHC-P (7)
WB (39)
Flo (3)
ELISA (5)
rabbit (45)
mouse (1)
Product Group
IHCPlus (1)
IgG (15)
IgG2a (1)
monoclonal mc (1)
polyclonal pc (45)
AP Conjugated (1)
APC (3)
APC Conjugated (4)
Biotin Conjugated (5)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (5)
Preservative Free (1)
Unconjugated (15)
aa1-118 (16)
aa1-117 (8)
C-Terminus (6)
aa309-323 (1)
aa334-358 (1)
No (104)
6His, N-terminus (1)
6His-SUMO, N-terminus (1)
DDK (Flag), C-terminus (3)
DDK (Flag), N-terminus (3)
Fc (1)
GFP, C-terminus (6)
GST (1)
HA, C-terminus (3)
HA, N-terminus (3)
His (3)
His, C-terminus (3)
His, N-terminus (3)
His-Fc (1)
His-GST (1)
Human IgG1 Fc, C-terminus (1)
Myc, C-terminus (3)
Myc, N-terminus (3)
Myc-DDK (Flag) (9)
OFP, C-terminus (3)
Untagged (6)
Ferret (13)
Human (13)
Mouse (13)
Lentiviral (3)
Mammalian (33)
Human (11)
Mouse (4)
Rat (1)
293T Cells (3)
E. coli (4)
HEK 293 Cells (7)
Human Cells (3)
Wheat Germ Extract (1)
Yeast (1)
Purified (5)
Low endotoxin level (4)
Select
SIGIRR Mouse anti-Human Monoclonal (APC) Antibody
Human
Flo
APC Conjugated
100 Tests/$777
Select
SIGIRR Rabbit anti-Human Polyclonal (PE) Antibody
Human
Flo
PE Conjugated
25 Tests/$276; 100 Tests/$351
SIGIRR Antibody - Anti-SIGIRR antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SIGIRR Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Horse, Rat, Mouse, Dog, Guinea pig, Bovine, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$485
SIGIRR Antibody - Anti-SIGIRR antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SIGIRR Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Zebrafish, Horse, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$421
SIGIRR Antibody - Anti-SIGIRR antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SIGIRR Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Zebrafish, Horse, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$421
SIGIRR Antibody - Anti-SIGIRR antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SIGIRR Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Zebrafish, Horse, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Monkey, Gibbon, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$421
SIGIRR Antibody - Western blot of recombinant SIGIRR.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
SIGIRR Rabbit anti-Mouse Polyclonal (aa1-117) Antibody
Mouse
WB
Unconjugated
100 µl/$312; 200 µl/$359; 500 µl/$518; 1 ml/$611
SIGIRR Antibody
Select
SIGIRR Rabbit anti-Human Polyclonal (aa1-118) (Biotin) Antibody
Pig, Human
WB
Biotin Conjugated
200 µl/$371; 500 µl/$541; 1 ml/$656
SIGIRR Antibody - Immunohistochemistry of paraffin-embedded human adrenal gland tissue at dilution 1:100
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SIGIRR Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$251; 100 µl/$285
Select
SIGIRR Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100 µg/$600
Select
SIGIRR Rabbit anti-Mouse Polyclonal (HRP) Antibody
Mouse, Human
IHC, WB
HRP Conjugated
100 µl/$791
Select
SIGIRR Rabbit anti-Mouse Polyclonal (Biotin) Antibody
Mouse, Human
IHC, WB
Biotin Conjugated
100 µl/$791
Select
SIGIRR Rabbit anti-Mouse Polyclonal (FITC) Antibody
Mouse, Human
IHC, WB
FITC Conjugated
100 µl/$791
Select
SIGIRR Rabbit anti-Mouse Polyclonal (AP) Antibody
Mouse, Human
IHC, WB
AP Conjugated
100 µl/$791
Select
SIGIRR Rabbit anti-Mouse Polyclonal (PE) Antibody
Mouse, Human
IHC, WB
PE Conjugated
100 µl/$791
SIGIRR NucleicAcid
Select
Mammalian
pCMV3-C-HA
HA, C-terminus
1 Each/$196
Select
SIGIRR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$347
SIGIRR Antibody - Immunohistochemistry of A549 cells with Rabbit anti-Mouse SIGIRR
Select
SIGIRR Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
IHC-Fr, WB
Unconjugated
50 µg/$320; 0.1 mg/$408
SIGIRR Antibody - Immunochemical staining SIGIRR in mouse kidney with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.
Select
SIGIRR Rabbit anti-Mouse Polyclonal (Preservative Free) Antibody
Mouse, Rat
IHC-P
Unconjugated, Preservative Free
50 µl/$275; 100 µl/$312; 200 µl/$350
Select
SIGIRR Rabbit anti-Human Polyclonal Antibody
Human
Flo
Unconjugated
50 µl/$290; 100 µl/$350
Select
SIGIRR Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µl/$275; 100 µl/$312; 200 µl/$350
Select
SIGIRR Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$275; 200 µl/$312; 400 µl/$350
Select
SIGIRR Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µl/$290; 100 µl/$350
SIGIRR Antibody - Western blot of human TIR8 in 15 ugs of (A) human kidney and (B) mouse kidney cell lysate using antibody at 0.5 ug/ml.
Select
SIGIRR Rabbit anti-Human Polyclonal (aa334-358) Antibody
Mouse, Human
WB
Unconjugated
100 µg/$376
SIGIRR Antibody - Western blot of SIGIRR in40 ugs of A) HCT-116 and B) A549cell lysate using antibody at 1:500 dilution.
Select
SIGIRR Rabbit anti-Human Polyclonal (aa309-323) Antibody
Human
WB
Unconjugated
200 µl/$376
Viewing 1-25 of 104 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).