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SHANK3

SH3 and multiple ankyrin repeat domains 3

Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.

Gene Name: SH3 and multiple ankyrin repeat domains 3
Synonyms: SHANK3, DEL22q13.3, KIAA1650, SPANK-2, PROSAP2, PSAP2, SCZD15
Target Sequences: NM_001080420 NP_001073889.1 Q9BYB0

Publications (1)

1
Usp9X Controls Ankyrin-Repeat Domain Protein Homeostasis during Dendritic Spine Development. Sehyoun Yoon, Euan Parnell, Maria Kasherman, Marc P Forrest, Kristoffer Myczek, Susitha Premarathne, Michelle C Sanchez Vega, Michael Piper, Thomas H J Burne, Lachlan A Jolly, Stephen A Wood, Peter Penzes. Neuron. 2020 February;105:506-521.e7. [Full Text Article] [PubMed:31813652] [PMC:PMC7007386] Related Antibodies: LS-C290822.

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Products
Antibodies (27)
Primary (27)
SHANK3 (27)
Human (26)
Mouse (25)
Rat (24)
Bovine (1)
Hamster (1)
Horse (1)
Monkey (1)
IHC (22)
WB (25)
ELISA (2)
ICC (11)
IF (21)
IP (12)
Peptide-ELISA (1)
rabbit (6)
mouse (21)
IgG (5)
IgG2a (10)
IgG2b (11)
monoclonal mc (21)
polyclonal pc (6)
S367-51 (10)
S69-46 (11)
AP Conjugated (1)
APC Conjugated (2)
Atto 390 Conjugated (2)
Atto 488 Conjugated (2)
Atto 594 Conjugated (2)
Biotin Conjugated (2)
FITC Conjugated (2)
PerCP Conjugated (2)
RPE Conjugated (2)
Unconjugated (10)
aa840-857 (11)
Internal (1)
aa1475-1525 (1)
aa1691-1741 (1)
No (26)
Yes (1)
SHANK3 Antibody - Detection of Human and Mouse SHANK3 by Western Blot. Samples: Whole cell lysate (50 ug) from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-SHANK3 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.
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SHANK3 Rabbit anti-Human Polyclonal (aa1475-1525) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
SHANK3 Antibody - Adult Rat hippocampus
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SHANK3 Mouse anti-Human Monoclonal (aa840-857) (S69-46) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
100 µg/$537
SHANK3 Antibody - Immunohistochemistry of SHANK3 in human brain tissue with SHANK3 antibody at 2.5 ug/ml.
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SHANK3 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
0.1 mg/$460
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SHANK3 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
500 µg/$393
SHANK3 Antibody - Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (S69-46) Antibody
Mouse, Bovine, Rat, Hamster, Horse, Human, Monkey
ICC, IHC, IP, WB
Unconjugated
100 µg/$442
SHANK3 Antibody - Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (Biotin) (S69-46) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Biotin Conjugated
100 µg/$475
SHANK3 Antibody - Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (FITC) (S69-46) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
FITC Conjugated
100 µg/$472
SHANK3 Antibody - Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (Atto 390) (S69-46) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 390 Conjugated
100 µg/$479
SHANK3 Antibody - Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (Atto 488) (S69-46) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 488 Conjugated
100 µg/$479
SHANK3 Antibody - Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (Atto 594) (S69-46) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
Atto 594 Conjugated
100 µg/$479
SHANK3 Antibody - Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (AP) (S69-46) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
AP Conjugated
100 µg/$474
SHANK3 Antibody - Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (APC) (S69-46) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
APC Conjugated
100 µg/$478
SHANK3 Antibody - Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (PerCP) (S69-46) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
PerCP Conjugated
100 µg/$478
SHANK3 Antibody - Western blot analysis of Shank3 in rat brain membrane lysates using a 1:1000 dilution of SHANK3 antibody.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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SHANK3 Mouse anti-Rat Monoclonal (aa840-857) (RPE) (S69-46) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IP, WB
RPE Conjugated
100 µg/$477
SHANK3 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) SHANK1/SHANK3 Antibody. (D) Composite.
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SHANK3 Mouse anti-Human Monoclonal (S367-51) Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
100 µg/$442
SHANK3 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) SHANK1/SHANK3 Antibody. (D) Composite.
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SHANK3 Mouse anti-Human Monoclonal (Biotin) (S367-51) Antibody
Mouse, Rat, Human
IF, IHC, WB
Biotin Conjugated
100 µg/$475
SHANK3 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) SHANK1/SHANK3 Antibody. (D) Composite.
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SHANK3 Mouse anti-Human Monoclonal (FITC) (S367-51) Antibody
Mouse, Rat, Human
IF, IHC, WB
FITC Conjugated
100 µg/$472
SHANK3 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) SHANK1/SHANK3 Antibody. (D) Composite.
Select
SHANK3 Mouse anti-Human Monoclonal (RPE) (S367-51) Antibody
Mouse, Rat, Human
IF, IHC, WB
RPE Conjugated
100 µg/$477
SHANK3 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) SHANK1/SHANK3 Antibody. (D) Composite.
Select
SHANK3 Mouse anti-Human Monoclonal (PerCP) (S367-51) Antibody
Mouse, Rat, Human
IF, IHC, WB
PerCP Conjugated
100 µg/$478
SHANK3 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) SHANK1/SHANK3 Antibody. (D) Composite.
Select
SHANK3 Mouse anti-Human Monoclonal (APC) (S367-51) Antibody
Mouse, Rat, Human
IF, IHC, WB
APC Conjugated
100 µg/$478
SHANK3 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) SHANK1/SHANK3 Antibody. (D) Composite.
Select
SHANK3 Mouse anti-Human Monoclonal (Atto 594) (S367-51) Antibody
Mouse, Rat, Human
IF, IHC, WB
Atto 594 Conjugated
100 µg/$479
SHANK3 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) SHANK1/SHANK3 Antibody. (D) Composite.
Select
SHANK3 Mouse anti-Human Monoclonal (Atto 390) (S367-51) Antibody
Mouse, Rat, Human
IF, IHC, WB
Atto 390 Conjugated
100 µg/$479
SHANK3 Antibody - Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody, Clone S367-51. Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-SHANK1/SHANK3 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:100 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000; 1:5000 for 60 min RT, 5 min RT. Localization: Cytoplasm, Nucleus. Magnification: 60X. (A) DAPI (blue) nuclear stain. (B) Phalloidin Texas Red F-Actin stain. (C) SHANK1/SHANK3 Antibody. (D) Composite.
Select
SHANK3 Mouse anti-Human Monoclonal (Atto 488) (S367-51) Antibody
Mouse, Rat, Human
IF, IHC, WB
Atto 488 Conjugated
100 µg/$479
Select
SHANK3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
SHANK3 Antibody - Western blot analysis SHANK3 using Jurkat whole cells lysates
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SHANK3 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).