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SERPINF1 / PEDF

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Gene Name:	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
Synonyms:	SERPINF1, EPC-1, OI12, PEDF, Serpin F1, PIG35, OI6
Target Sequences:	NM_002615 NP_002606.3 P36955

Publications (4)

Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins. Rowland TJ, Blaschke AJ, Buchholz DE, Hikita ST, Johnson LV, Clegg DO. Journal of tissue engineering and regenerative medicine. 2013 August;7:642-653. [Full Text Article] [PubMed:22514096] Related Antibodies: LS-B2471.

Malignant ascites: a source of therapeutic protein against ovarian cancer?. Ribaux P, Britan A, Thumann G, Delie F, Petignat P, Cohen M. Oncotarget. 2019 October;10:5894-5905. [Full Text Article] [PubMed:31666922] [PMC:PMC6800269] Related Antibodies: LS-C100901.

CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization. Xiao Yang, Lian Zhao, Maria M Campos, Mones Abu-Asab, Davide Ortolan, Nathan Hotaling, Kapil Bharti, Wai T Wong. eLife. 2020 Apr;9:e55564. [Full Text Article] [PubMed:32234210] [PMC:PMC7156269]

Preterm birth prediction in asymptomatic women at mid-gestation using a panel of novel protein biomarkers: the Prediction of PreTerm Labor (PPeTaL) study. San Min Leow, Megan K W Di Quinzio, Zhen Long Ng, Claire Grant, Tal Amitay, Ying Wei, Moshe Hod, Penelope M Sheehan, Shaun P Brennecke, Nir Arbel, Harry M Georgiou. The Breast : official journal of the European Society of Mastology. 2020 May;;2:100084. [Full Text Article] [PubMed:33345955]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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