SDC1 / Syndecan 1 / CD138 is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
|Gene Name:||syndecan 1|
|Synonyms:||SDC1, CD138 antigen, SDC, SYND1, Syndecan, Syndecan 1, Syndecan-1, CD138, Syndecan proteoglycan 1|
|Target Sequences:||NM_002997 NP_002988.3 P18827|
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