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RPA2 / RFA2 / RPA34

replication protein A2, 32kDa

As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interaction with UNG. Through RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP, which is involved in replication fork restart, to sites of DNA damage. May also play a role in telomere maintenance.

Gene Name: replication protein A2, 32kDa
Synonyms: RPA2, RF-A protein 2, RP-A p34, RPA34, Replication protein A2, 32kDa, RP-A p32, REPA2, Replication factor A protein 2, Replication protein A2 (32kD), RPA32
Target Sequences: NM_002946 NP_002937.1 P15927

Publications (3)

1
Pre-exposure to ionizing radiation stimulates DNA double strand break end resection, promoting the use of homologous recombination repair. Nakajima NI, Hagiwara Y, Oike T, Okayasu R, Murakami T, Nakano T, Shibata A. PloS one. 2015 10:e0122582. (WB, IF; Human) [Full Text Article] [PubMed:25826455] [PMC:PMC4380452] Related Antibodies: LS-C38952.
2
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, Maity R, van Rossum-Fikkert S, Kertokalio A, Romoli F, Ismail A, Ismalaj E, Petricci E, Neale MJ, Bristow RG, Masson JY, Wyman C, Jeggo PA, Tainer JA. Molecular cell. Jan;53:7-18. [Full Text Article] [PubMed:24316220] [PMC:PMC3909494] Related Antibodies: LS-C38952.
3
Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE, El-Khamisy SF. Nucleic acids research. 2017 45:1159-1176. (WB; Human) [Full Text Article] [PubMed:28180300] [PMC:PMC5388393] Related Antibodies: LS-C38952.

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RPA2 / RFA2 / RPA34 (81)
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RPA2 / RFA2 / RPA34 Rat anti-Human Monoclonal Antibody
Mouse, Rat, Hamster, Human, Monkey
ICC, IF, IP, WB
Unconjugated
100 µl/$702
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RPA2 / RFA2 / RPA34 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$341
RPA2 / RFA2 / RPA34 Antibody - Detection of Human and Mouse RPA32 (S4/S8) by Immunohistochemistry. Sample: FFPE sections of human ovarian carcinoma (left) and mouse renal cell carcinoma (right). Antibody: Affinity purified rabbit anti-RPA32 (S4/S8) used at a dilution of 1:1000 (1 Detection: DAB.
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RPA2 / RFA2 / RPA34 Rabbit anti-Human Polyclonal (pSer4/8) Antibody
Mouse, Human
ICC, IF, IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$533
RPA2 / RFA2 / RPA34 Antibody - Anti-RPA2 / RFA2 / RPA34 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RPA2 / RFA2 / RPA34 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
RPA2 / RFA2 / RPA34 Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 5 ug/ml.
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RPA2 / RFA2 / RPA34 Goat anti-Human Polyclonal (aa220-270) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
RPA2 / RFA2 / RPA34 Antibody - Detection of Human Phospho-RPA32 (S4/S8) by Immunohistochemistry. Samples: FFPE serial sections of human breast carcinoma. Mock phosphatase treated section (left) or calf intestinal phosphatase-treated section (right) immunostained for Phospho-RPA32 (S4/S8). Antibody: Affinity purified rabbit anti-Phospho-RPA32 (S4/S8) used at a dilution of 1:250.
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RPA2 / RFA2 / RPA34 Rabbit anti-Human Polyclonal (pSer4/8) Antibody
Mouse, Human
IF, IHC
Unconjugated
1 µg/$295; 100 µl/$554
RPA2 / RFA2 / RPA34 Antibody - Anti-RPA2 / RFA2 / RPA34 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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RPA2 / RFA2 / RPA34 Rabbit anti-Human Polyclonal (aa225-C-term) Antibody
Mouse, Human
IF, IHC, IHC-P
Unconjugated
50 µl/$460
RPA2 / RFA2 / RPA34 Antibody - IHC of paraffin-embedded colon tissue using anti-RPA2 mouse monoclonal antibody. (Dilution 1:50).
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RPA2 / RFA2 / RPA34 Mouse anti-Human Monoclonal (OTI3A12) Antibody
Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$434
RPA2 / RFA2 / RPA34 Antibody - IHC of paraffin-embedded colon tissue using anti-RPA2 mouse monoclonal antibody. (Dilution 1:50).
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RPA2 / RFA2 / RPA34 Mouse anti-Human Monoclonal (Carrier-free) (OTI3A12) Antibody
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
RPA2 / RFA2 / RPA34 Antibody - IHC of paraffin-embedded thyroid tissue using anti-RPA2 mouse monoclonal antibody. (Dilution 1:50).
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RPA2 / RFA2 / RPA34 Mouse anti-Human Monoclonal (OTI9A1) Antibody
Human, Monkey
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$434
RPA2 / RFA2 / RPA34 Antibody - IHC of paraffin-embedded thyroid tissue using anti-RPA2 mouse monoclonal antibody. (Dilution 1:50).
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RPA2 / RFA2 / RPA34 Mouse anti-Human Monoclonal (Carrier-free) (OTI9A1) Antibody
Human, Monkey
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
RPA2 / RFA2 / RPA34 Antibody - IHC of paraffin-embedded breast tissue using anti-RPA2 mouse monoclonal antibody. (Dilution 1:50).
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RPA2 / RFA2 / RPA34 Mouse anti-Human Monoclonal (OTI1H10) Antibody
Dog, Rat, Human, Monkey
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$434
RPA2 / RFA2 / RPA34 Antibody - IHC of paraffin-embedded breast tissue using anti-RPA2 mouse monoclonal antibody. (Dilution 1:50).
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RPA2 / RFA2 / RPA34 Mouse anti-Human Monoclonal (Carrier-free) (OTI1H10) Antibody
Dog, Rat, Human, Monkey
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
RPA2 / RFA2 / RPA34 Antibody - IHC of paraffin-embedded breast tissue using anti-RPA2 mouse monoclonal antibody. (Dilution 1:50).
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RPA2 / RFA2 / RPA34 Mouse anti-Human Monoclonal (OTI7C12) Antibody
Dog, Human, Monkey
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$434
RPA2 / RFA2 / RPA34 Antibody - IHC of paraffin-embedded breast tissue using anti-RPA2 mouse monoclonal antibody. (Dilution 1:50).
Select
RPA2 / RFA2 / RPA34 Mouse anti-Human Monoclonal (Carrier-free) (OTI7C12) Antibody
Dog, Human, Monkey
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
RPA2 / RFA2 / RPA34 Antibody - IHC of paraffin-embedded breast tissue using anti-RPA2 mouse monoclonal antibody. (Dilution 1:50).
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RPA2 / RFA2 / RPA34 Mouse anti-Human Monoclonal (OTI8B3) Antibody
Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$434
RPA2 / RFA2 / RPA34 Antibody - IHC of paraffin-embedded breast tissue using anti-RPA2 mouse monoclonal antibody. (Dilution 1:50).
Select
RPA2 / RFA2 / RPA34 Mouse anti-Human Monoclonal (Carrier-free) (OTI8B3) Antibody
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
RPA2 / RFA2 / RPA34 Antibody - IHC of paraffin-embedded liver tissue using anti-RPA2 mouse monoclonal antibody. (Dilution 1:50).
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RPA2 / RFA2 / RPA34 Mouse anti-Human Monoclonal (OTI10G1) Antibody
Human
Flo, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$434
RPA2 / RFA2 / RPA34 Antibody - IHC of paraffin-embedded liver tissue using anti-RPA2 mouse monoclonal antibody. (Dilution 1:50).
Select
RPA2 / RFA2 / RPA34 Mouse anti-Human Monoclonal (Carrier-free) (OTI10G1) Antibody
Human
Flo, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
RPA2 / RFA2 / RPA34 Antibody - Immunohistochemical analysis of RPA2 (pT21) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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RPA2 / RFA2 / RPA34 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
RPA2 / RFA2 / RPA34 Antibody - Immunohistochemistry of paraffin-embedded human kidney cancer tissue.
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RPA2 / RFA2 / RPA34 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, IP, WB
Unconjugated
20 µl/$275; 100 µl/$389
RPA2 / RFA2 / RPA34 Antibody - Anti-RPA2 / RFA2 / RPA34 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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RPA2 / RFA2 / RPA34 Rabbit anti-Human Polyclonal (aa225-C-term) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$460
RPA2 / RFA2 / RPA34 Antibody - 1:100 staining human liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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RPA2 / RFA2 / RPA34 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
RPA2 / RFA2 / RPA34 Antibody - 1:200 staining human brain tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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RPA2 / RFA2 / RPA34 Rabbit anti-Human Polyclonal (pThr21) Antibody
Mouse, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
RPA2 / RFA2 / RPA34 Antibody - Western blot of RFA2 expression in K562 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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RPA2 / RFA2 / RPA34 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).