ROCK2

Rho-associated, coiled-coil containing protein kinase 2

Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca2+ sensitivity and vascular contractility by modulating the myosin light chain phosphorylation.

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Products

Antibodies (50)

Type

Primary (50)

Target

ROCK2 (50)

Reactivity

Human (50)

Mouse (28)

Rat (28)

Bat (3)

Bovine (5)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Horse (3)

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Application

IHC (17)

IHC-P (11)

WB (41)

ELISA (15)

IF (5)

IP (5)

Peptide-ELISA (4)

Host

rabbit (49)

mouse (1)

Product Group

IHCPlus (3)

Isotype

IgG (20)

IgG1,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (49)

Clone

1E12 (1)

Format

APC (1)

APC Conjugated (1)

Biotin Conjugated (4)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (4)

HRP Conjugated (4)

Magnetic beads Conjugated (1)

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Epitope

aa904-1140 (8)

Internal (4)

N-Terminus (4)

aa511-560 (4)

pTyr722 (2)

660-740 aa (1)

C-Terminus (1)

aa1040-1073 (1)

aa1109-1388 (1)

aa1320-C-term (1)

aa1346-1380 (1)

aa652-923 (1)

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Publications

No (50)

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IHC-plus™ ROCK2 Antibody (clone 1E12) LS-B4486

(4.0) Rating

Antibody:

ROCK2 Mouse anti-Human Monoclonal (1E12) Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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ROCK2 Antibody (phospho-Tyr256) LS-C60110

Antibody:

ROCK2 Rabbit anti-Human Polyclonal (pTyr256) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$567

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ROCK2 Antibody LS-C334228

Antibody:

ROCK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389

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ROCK2 Antibody (aa1109-1388) LS-C376532

Antibody:

ROCK2 Rabbit anti-Human Polyclonal (aa1109-1388) Antibody

Reactivity:

Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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ROCK2 Antibody (p722) LS-C825683

Antibody:

ROCK2 Rabbit anti-Human Polyclonal (p722) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

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IHC-plus™ ROCK2 Antibody LS-B7101

(4.0) Rating

Antibody:

ROCK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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ROCK2 Antibody LS-C660579

Antibody:

ROCK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$341

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ROCK2 Antibody LS-C660580

Antibody:

ROCK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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ROCK2 Antibody (aa511-560) LS-B6964

Antibody:

ROCK2 Rabbit anti-Human Polyclonal (aa511-560) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

100 µl/$485

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ROCK2 Antibody (N-Terminus, Sepharose) LS-C172065

Antibody:

ROCK2 Rabbit anti-Human Polyclonal (N-Terminus) (Sepharose) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IP

Format:

Sepharose Conjugated

Price:

100 µg/$399

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ROCK2 Antibody LS-C490068

Antibody:

ROCK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$575

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ROCK2 Antibody (aa652-923) LS-C357576

Antibody:

ROCK2 Rabbit anti-Human Polyclonal (aa652-923) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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ROCK2 Antibody (N-Terminus) LS-C122396

Antibody:

ROCK2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$564

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ROCK2 Antibody (N-Terminus) LS-C172063

Antibody:

ROCK2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µg/$380

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ROCK2 Antibody LS-C341296

Antibody:

ROCK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µl/$356; 100 µl/$461

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ROCK2 Antibody LS-C742588

Antibody:

ROCK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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ROCK2 Antibody (660-740 aa) LS-C385938

Antibody:

ROCK2 Rabbit anti-Human Polyclonal (660-740 aa) Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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ROCK2 Antibody LS-C742942

Antibody:

ROCK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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ROCK2 Antibody LS-C679343

Antibody:

ROCK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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ROCK2 Antibody LS-C831703

Antibody:

ROCK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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ROCK2 Antibody (aa1320-C-term) LS-C286988

Antibody:

ROCK2 Rabbit anti-Human Polyclonal (aa1320-C-term) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

ROCK2 Antibody (aa1040-1073) LS-C356727

Antibody:

ROCK2 Rabbit anti-Human Polyclonal (aa1040-1073) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

400 µl/$393

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ROCK2 Antibody (aa1346-1380) LS-C356729

Antibody:

ROCK2 Rabbit anti-Human Polyclonal (aa1346-1380) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

ROCK2 Antibody (phospho-Tyr722) LS-C800888

Antibody:

ROCK2 Rabbit anti-Human Polyclonal (pTyr722) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

ROCK2 Antibody LS-C801538

Antibody:

ROCK2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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