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Rat IgM

Immunoglobulin M, or IgM for short, is a basic antibody that is produced by B cells. IgM is by far the physically largest antibody in the human circulatory system. It is the first antibody to appear in response to initial exposure to an antigen. The spleen where plasmablasts reside is the major site of specific IgM production. IgM forms polymers where multiple immunoglobulins are covalently linked together with disulfide bonds, mostly as a pentamer but also as a hexamer. IgM has a molecular mass of approximately 970 kDa (in its pentamer form). Because each monomer has two antigen binding sites, a pentameric IgM has 10 binding sites. Typically, however, IgM cannot bind 10 antigens at the same time because the large size of most antigens hinders binding to nearby sites. The J chain is found in pentameric IgM but not in the hexameric form, perhaps due to space constraints in the hexameric complex. Pentameric IgM can also be made in the absence of J chain. At present, it is still uncertain what fraction of normal pentamer contains J chain, and to this extent it is also uncertain whether a J chain-containing pentamer contains one or more than one J chain. Although hexameric IgM without J chain has higher efficiency of complement fixation than pentameric IgM with J chain. Because IgM is a large molecule, it cannot diffuse well, and is found in the interstitium only in very low quantities. IgM is primarily found in serum; however, because of the J chain, it is also important as a secretory immunoglobulin. Due to its polymeric nature, IgM possesses high avidity, and is particularly effective at complement activation. By itself, IgM is an ineffective opsonin; however it contributes greatly to opsonization by activating complement and causing C3b to bind to the antigen.

Rat IgM Target Details

Target Name: Rat IgM

☰ Filters
Antibodies (87)
ELISA Kits (3)
Proteins (1)
Native (1)
Sandwich (2)
Sandwich CLIA (1)
Secondary (87)
Rat IgM (91)
Human (1)
Rat (90)
IHC (47)
IHC-Fr (2)
WB (41)
Flo (40)
ELISA (52)
FLISA (14)
ICC (26)
ID (1)
IE (1)
IF (29)
IP (2)
rabbit (16)
mouse (18)
goat (53)
IgG (58)
IgG F(ab')2 (1)
IgG1 (18)
IgM (4)
monoclonal mc (18)
polyclonal pc (69)
M2A1 (7)
MARM-4 (3)
96-Well Strip Plate (3)
AP Conjugated (7)
Azide-free (1)
Biotin Conjugated (12)
Cy5 Conjugated (1)
DY488 Conjugated (2)
DY550 Conjugated (2)
DY594 Conjugated (2)
DY650 Conjugated (2)
DY680 Conjugated (1)
DY755 Conjugated (1)
DY800 Conjugated (1)
Fab'2 (2)
FITC Conjugated (13)
Gold Conjugated (1)
HRP Conjugated (13)
Low Endotoxin (1)
PE Conjugated (3)
Rhodamine Conjugated (2)
RPE Conjugated (2)
TR Conjugated (4)
TRITC Conjugated (4)
Unconjugated (14)
No (91)
Plasma (3)
Serum (3)
Tissue Homogenates (1)
Rat (1)
Rat (1)
Select
Rat IgM Rabbit anti-Rat Polyclonal Antibody
Rat
ELISA, ID, IHC, IP, WB
Unconjugated
2 mg/$531
Select
Rat IgM Rabbit anti-Rat Polyclonal (HRP) Antibody
Rat
ELISA, IHC, WB
HRP Conjugated
500 µg/$423
Rat IgM Antibody - Western Blot of Anti-Rat IgM (mu chain) (RABBIT) Antibody  Lane M: 3 µl Molecular Ladder. Lane 1: Rat IgG whole molecule  Lane 2: Rat IgG F(c) Fragment  Lane 3: Rat IgG Fab Fragment  Lane 4: Rat IgM Whole Molecule  Lane 5: Rat Serum  All samples were reduced. Load: 50 ng per lane.
Select
Rat IgM Rabbit anti-Rat Polyclonal (TR) Antibody
Rat
FLISA, Flo, IF, WB
TR Conjugated
1.5 mg/$376
Select
Rat IgM Rabbit anti-Rat Polyclonal (FITC) Antibody
Rat
ELISA, IF, WB
FITC Conjugated
500 µg/$424
Rat IgM Antibody - Western Blot of Anti-Rat IgM (mu chain) (RABBIT) Antibody  Lane M: 3 µl Molecular Ladder. Lane 1: Rat IgG whole molecule  Lane 2: Rat IgG F(c) Fragment  Lane 3: Rat IgG Fab Fragment  Lane 4: Rat IgM Whole Molecule  Lane 5: Rat Serum  All samples were reduced. Load: 50 ng per lane.
Select
Rat IgM Rabbit anti-Rat Polyclonal (Biotin) Antibody
Rat
ELISA, IHC, WB
Biotin Conjugated
1.5 mg/$376
Select
Rat IgM Goat anti-Rat Polyclonal (HRP) Antibody
Rat
ELISA, IHC, WB
HRP Conjugated
1 mg/$694
Select
Rat IgM Goat anti-Rat Polyclonal (RPE) Antibody
Rat
Flo, IF
RPE Conjugated
1 ml/$487
Select
Rat IgM Mouse anti-Rat Monoclonal (MARM-4) Antibody
Rat
ELISA
Unconjugated
0.25 mg/$464
Select
Rat IgM Goat anti-Rat Polyclonal (DY488) Antibody
Rat
Flo, ICC, IF, IHC
DY488 Conjugated
1 ml/$325
Select
Rat IgM Goat anti-Rat Polyclonal (DY594) Antibody
Rat
Flo, ICC, IF, IHC
DY594 Conjugated
1 ml/$325
Select
Rat IgM Goat anti-Rat Polyclonal (DY550) Antibody
Rat
Flo, ICC, IF, IHC
DY550 Conjugated
1 ml/$325
Select
Rat IgM Goat anti-Rat Polyclonal (DY650) Antibody
Rat
Flo, ICC, IF, IHC
DY650 Conjugated
1 ml/$325
Select
Rat IgM Goat anti-Rat Polyclonal (DY488) Antibody
Rat
Flo, ICC, IF, IHC
DY488 Conjugated
1 ml/$332
Select
Rat IgM Goat anti-Rat Polyclonal (DY680) Antibody
Rat
Flo, ICC, IF, IHC
DY680 Conjugated
1 ml/$332
Select
Rat IgM Goat anti-Rat Polyclonal (DY594) Antibody
Rat
Flo, ICC, IF, IHC
DY594 Conjugated
1 ml/$332
Select
Rat IgM Goat anti-Rat Polyclonal (DY650) Antibody
Rat
Flo, ICC, IF, IHC
DY650 Conjugated
1 ml/$332
Select
Rat IgM Goat anti-Rat Polyclonal (DY550) Antibody
Rat
Flo, ICC, IF, IHC
DY550 Conjugated
1 ml/$332
Select
Rat IgM Goat anti-Rat Polyclonal (DY755) Antibody
Rat
Flo, ICC, IF, IHC
DY755 Conjugated
1 ml/$332
Select
Rat IgM Goat anti-Rat Polyclonal (FITC) Antibody
Rat
Flo, ICC, IF, IHC
FITC Conjugated
1 ml/$305
Select
Rat IgM Goat anti-Rat Polyclonal (DY800) Antibody
Rat
Flo, ICC, IF, IHC
DY800 Conjugated
1 ml/$332
Select
Rat IgM Goat anti-Rat Polyclonal Antibody
Rat
ELISA, Flo, IHC, WB
Unconjugated
1 mg/$281
Select
Rat IgM Goat anti-Rat Polyclonal Antibody
Rat
ELISA, ICC, IHC, WB
Unconjugated
1 mg/$344
Select
Rat IgM Goat anti-Rat Polyclonal Antibody
Rat
ELISA, ICC, IHC, WB
Unconjugated
1 ml/$285
Select
Rat IgM Rabbit anti-Rat Polyclonal (Biotin) Antibody
Rat
ELISA, IF, IHC, WB
Biotin Conjugated
1.5 mg/$579
Select
Rat IgM Goat anti-Rat Polyclonal (Biotin) Antibody
Rat
ELISA, IF, IHC, WB
Biotin Conjugated
1 mg/$615
Viewing 1-25 of 91 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).