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Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization.
Gene Name: | spindle and kinetochore associated complex subunit 3 |
Synonyms: | SKA3, C13orf3, RAMA1 |
Target Sequences: | NM_145061 NP_659498.4 Q8IX90 |
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