PTK6 / BRK

protein tyrosine kinase 6

Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP, PXN/paxillin, BTK/ATK, STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways, or for which PTK6 may play an adapter-like role. These proteins include ADAM15, EGFR, ERBB2, ERBB3 and IRS4. In normal or non-tumorigenic tissues, PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation, anchorage-independent survival and migration/invasion. Association with EGFR, ERBB2, ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP, which promotes association with RASA1/p120RasGAP, inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia, while cytoplasmic PTK6 might activate oncogenic signaling pathways.Isoform 2 inhibits PTK6 phosphorylation and PTK6 association with other tyrosine-phosphorylated proteins.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

PTK6 / BRK (8)

Publications

No (8)

Tag

GST (2)

GST, N-terminus (1)

His/GST,N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Mouse (1)

Source

293T Cells (1)

Baculovirus (1)

E. coli (1)

HEK 293 Cells (2)

Insect Cells (1)

Wheat Germ Extract (2)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (2)

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PTK6 / BRK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115620

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.7 kDa

Price:

100 µg/$494

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Human PTK6 / BRK Protein (Recombinant His-T7) (aa191-445) - LS-G25457

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.9 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human PTK6 / BRK Protein (Recombinant GST, N-terminus) (aa342-451) - LS-G59812

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PTK6 / BRK Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80779

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.7 kDa

Price:

20 µg/$150

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Human PTK6 / BRK Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67818

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.7 kDa

Price:

20 µg/$1,107

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Human PTK6 / BRK Protein (Recombinant GST) (Met1-Thr451) - LS-G97524

Source:

Baculovirus

Tag:

GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

78 kDa

Price:

50 µg/$707

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Mouse PTK6 / BRK Protein (Recombinant His/GST,N-terminus) (Met1-Val451) - LS-G140014

Source:

Insect Cells

Tag:

His/GST,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

79.8 kDa

Price:

50 µg/$707

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Human PTK6 / BRK Protein (Recombinant GST) (Full Length) - LS-G30028

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78.2 kDa

Price:

2 µg/$439

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