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Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.
|Family/Subfamily:||Endogenous opioids , not assigned-Endogenous opioids|
|Synonyms:||PENK, Enkephalin A, Met enkephalin, Preproenkephalin, Proenkephalin, Proenkephalin-A|
|Target Sequences:||NM_006211 NP_006202.1 P01210|
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