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Proenkephalin / PENK

proenkephalin

Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.

Gene Name: proenkephalin
Family/Subfamily: Endogenous opioids , not assigned-Endogenous opioids
Synonyms: PENK, Enkephalin A, Met enkephalin, Preproenkephalin, Proenkephalin, Proenkephalin-A
Target Sequences: NM_006211 NP_006202.1 P01210

Publications (6)

1
Classes and continua of hippocampal CA1 inhibitory neurons revealed by single-cell transcriptomics. Harris KD, Hochgerner H, Skene NG, Magno L, Katona L, Bengtsson Gonzales C, Somogyi P, Kessaris N, Linnarsson S, Hjerling-Leffler J. PLoS biology. 2018 June;16:e2006387. (Rat) [Full Text Article] [PubMed:29912866] [PMC:PMC6029811]
2
Dynamic postnatal development of the cellular and circuit properties of striatal D1 and D2 spiny projection neurons. Krajeski RN, Macey-Dare A, van Heusden F, Ebrahimjee F, Ellender TJ. The Journal of physiology. 2019 November;597:5265-5293. [Full Text Article] [PubMed:31531863] [PMC:PMC6900874]
3
Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of nonopioid peptides as potent analgesics in a rat model of neuropathic pain. Anna Piotrowska, Joanna Starnowska-Sokól, Wioletta Makuch, Joanna Mika, Ewa Witkowska, Dagmara Tymecka, Angelika Ignaczak, Beata Wilenska, Aleksandra Misicka, Barbara Przewlocka. Pain. 2021 February;162:432-445. [Full Text Article] [PubMed:32826750] [PMC:PMC7808367] Related Antibodies: LS-B15645.
4
A Disynaptic Circuit in the Globus Pallidus Controls Locomotion Inhibition. Asier Aristieta, Massimo Barresi, Shiva Azizpour Lindi, Grégory Barrière, Gilles Courtand, Brice de la Crompe, Lise Guilhemsang, Sophie Gauthier, Stéphanie Fioramonti, Jérôme Baufreton, Nicolas P Mallet. Current biology : CB. 2020 December; [Full Text Article] [PubMed:33306949]
5
Secretagogin expression delineates functionally-specialized populations of striatal parvalbumin-containing interneurons. Farid N Garas, Rahul S Shah, Eszter Kormann, Natalie M Doig, Federica Vinciati, Kouichi C Nakamura, Matthijs C Dorst, Yoland Smith, Peter J Magill, Andrew Sharott. eLife. 2016 Sep;5:e16088. [Full Text Article] [PubMed:27669410] [PMC:PMC5036963]
6
Diversity in striatal synaptic circuits arises from distinct embryonic progenitor pools in the ventral telencephalon. Fran van Heusden, Anežka Macey-Dare, Jack Gordon, Rohan Krajeski, Andrew Sharott, Tommas Ellender. Cell reports. 2021 Apr;35:109041. [Full Text Article] [PubMed:33910016] [PMC:PMC8097690]
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ELISA Kits (8)
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Proenkephalin / PENK (8)
Human (3)
Mouse (2)
Rat (2)
96-Well Strip Plate (8)
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Cell Culture Supernatants (2)
Cell Lysates (1)
Plasma (7)
Serum (7)
Tissue Homogenates (5)
Proenkephalin / PENK ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$854
Proenkephalin / PENK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$834
Proenkephalin / PENK ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Proenkephalin / PENK ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Proenkephalin / PENK ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum, Tissue Homogenates
1 Plate/$669
Proenkephalin / PENK ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
Proenkephalin / PENK ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
Proenkephalin / PENK ELISA Kit
Select
Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$669
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).