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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PRMT5

protein arginine methyltransferase 5

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation. Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9. Methylates and regulates SRGAP2 which is involved in cell migration and differentiation. Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter.

Gene Name: protein arginine methyltransferase 5
Synonyms: PRMT5, 72 kDa ICln-binding protein, HRMT1L5, JBP1, Jak-binding protein 1, IBP72, SKB1Hs, SKB1, SKB1 homolog, Skb1 (S. pombe) homolog, SKB1 homolog (S. pombe)
Target Sequences: NM_006109 NP_006100.2 O14744

Viewing 1-25 of 65 items
PRMT5 Antibody - Anti-PRMT5 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Mouse, Rat, Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
50µl   0.2mg/ml   $515.00
PRMT5 Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal to Human PRMT5
Human
IHC, IHC-P, WB
Unconjugated
50µg   $425.00
Select
Rabbit Monoclonal to Human PRMT5
Human
IF, IHC, WB
Unconjugated
50µl   $295.00; 100µl   $385.00; 200µl   $560.00
PRMT5 Antibody - PRMT5 antibody ARP40185_T100-NP_001034708-PRMT5 (protein arginine methyltransferase 5) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Zebrafish, Pig, Horse, Bat, Rabbit, Mouse, Dog, Guinea pig, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $325.00
PRMT5 Antibody - PRMT5 antibody ARP40185_T100-NP_001034708-PRMT5 (protein arginine methyltransferase 5) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Guinea pig, Bat, Rat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $335.00
PRMT5 Antibody - Immunohistochemistry of paraffin-embedded human stomach using COL5A1 antibody at dilution of 1:200 (x400 lens)
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Mouse, Rat, Human, Monkey
IF, IHC, WB
Unconjugated
50µl   $235.00; 100µl   $315.00; 200µl   $425.00
PRMT5 Antibody - Immunohistochemistry of paraffin-embedded human brain tissue at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Human
ELISA, IF, IHC, IHC-P
Unconjugated
50µg   $285.00; 100µg   $385.00
PRMT5 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-PRMT5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI4G7] (IgG1) to Human PRMT5
Human
IHC, IHC-P
Unconjugated
100µl   1mg/ml   $345.00
PRMT5 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-PRMT5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
Select
Mouse Monoclonal [clone OTI4G7] (IgG1) to Human PRMT5
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
PRMT5 Antibody - IHC of paraffin-embedded Human colon tissue using anti-PRMT5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI2C12] (IgG2b) to Human PRMT5
Human
IHC, IHC-P
Unconjugated
100µl   1mg/ml   $345.00
PRMT5 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-PRMT5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
Select
Mouse Monoclonal [clone OTI2C12] (IgG2b) to Human PRMT5
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Mouse, Rat, Human, Monkey
IF, IHC, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
PRMT5 Antibody - Immunohistochemistry of paraffin-embedded Human breast cancer using PRMT5 Polyclonal Antibody at dilution of 1:20.
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Rabbit Polyclonal (IgG) to Human PRMT5
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20µl   0.3mg/ml   $205.00; 60µl   0.3mg/ml   $235.00; 120µl   0.3mg/ml   $295.00; 200µl   0.3mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Human
ELISA, IHC, WB
Unconjugated
100µg   $335.00
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human PRMT5
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
PRMT5 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-PRMT5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Select
Mouse Monoclonal [clone OTI2H3] (IgG2a) to Human PRMT5
Human
IHC
Unconjugated
100µl   1mg/ml   $345.00
PRMT5 Antibody - Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-PRMT5 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Select
Mouse Monoclonal [clone OTI2H3] (IgG2a) to Human PRMT5
Human
IHC
Unconjugated, Carrier-free
100µg   $395.00
PRMT5 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Select
Rabbit Polyclonal to Human PRMT5
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
PRMT5 Antibody - PRMT5 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human testis tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
Rabbit Polyclonal to Human PRMT5
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00

Viewing 1-25 of 65 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).