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POLB / DNA Polymerase Beta

polymerase (DNA directed), beta

Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases.

Gene Name: polymerase (DNA directed), beta
Synonyms: POLB, DNA pol beta, Mutant DNA polymerase beta, DNA polymerase beta, DNA polymerase beta subunit
Target Sequences: NM_002690 NP_002681.1 P06746

Publications (2)

1
Regulated over-expression of DNA polymerase beta mediates early onset cataract in mice. Sobol RW, Foley JF, Nyska A, Davidson MG, Wilson SH. DNA repair. 2003 2:609-22. [PubMed:12713817] Related Antibodies: LS-C153861.
2
DNA polymerase beta-dependent long patch base excision repair in living cells. Asagoshi K, Liu Y, Masaoka A, Lan L, Prasad R, Horton JK, Brown AR, Wang XH, Bdour HM, Sobol RW, Taylor JS, Yasui A, Wilson SH. DNA repair. 2010 9:109-19. [PubMed:20006562] [PMC:PMC2819632] Related Antibodies: LS-C153861.

☰ Filters
Products
Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
POLB / DNA Polymerase Beta (7)
No (7)
6His, C-terminus (2)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (2)
Human (6)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (2)
POLB / DNA Polymerase Beta Protein
Select
E. coli
His
40.3 kDa
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39.23kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
POLB / DNA Polymerase Beta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
38 kDa
100 µg/$494
POLB / DNA Polymerase Beta Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
Select
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
POLB / DNA Polymerase Beta Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
38 kDa
20 µg/$150
Select
E. coli
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
39.2 kDa
10 µg/$376; 50 µg/$526
POLB / DNA Polymerase Beta Protein - 12.5% SDS-PAGE of human POLB stained with Coomassie Blue
Select
Wheat Germ Extract
GST
64.6 kDa
10 µg/$479; 25 µg/$670
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).