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PLIN2 / ADFP / Adipophilin

perilipin 2

PLIN2 / ADFP / Adipophilin belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene.

Gene Name:	perilipin 2
Synonyms:	PLIN2, Adipophilin, ADFP, ADRP, Perilipin 2, Perilipin-2, Adipose differentiation-related protein
Target Sequences:	NM_001122 NP_001113.2 Q99541

Publications (14)

Lipolytic signaling in response to acute exercise is altered in female mice following ovariectomy. Wohlers LM, Jackson KC, Spangenburg EE. Journal of cellular biochemistry. 2011 112:3675-84. [PubMed:21815195] [PMC:PMC3202083]

Perilipin 2 (PLIN2)-deficiency does not increase cholesterol-induced toxicity in macrophages. Son SH, Goo YH, Chang BH, Paul A. PloS one. 2012 7:e33063. (WB; Mouse) [PubMed:22427949] [PMC:PMC3299742]

A novel Rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets. Li Z, Schulze RJ, Weller SG, Krueger EW, Schott MB, Zhang X, Casey CA, Liu J, Stöckli J, James DE, McNiven MA. Science advances. 2016 2:e1601470. (WB, IF; Mouse, Human) [Full Text Article] [PubMed:28028537] [PMC:PMC5161429]

Clinicoplacental correlates of amniocyte vacuolization in association with gastroschisis. De Paepe ME, Mao Q, Chu S, Zhang Y, Luks FI. Placenta. 2017 57:87-93. (IHC; Human) [Full Text Article] [PubMed:28864023]

Metformin inhibits stromal aromatase expression and tumor progression in a rodent model of postmenopausal breast cancer. Giles ED, Jindal S, Wellberg EA, Schedin T, Anderson SM, Thor AD, Edwards DP, MacLean PS, Schedin P. Breast cancer research : BCR. 2018 June;20:50. (Human) [Full Text Article] [PubMed:29898754] [PMC:PMC6000949]

DGAT1 Inhibitor Suppresses Prostate Tumor Growth and Migration by Regulating Intracellular Lipids and Non-Centrosomal MTOC Protein GM130. Nardi F, Franco OE, Fitchev P, Morales A, Vickman RE, Hayward SW, Crawford SE. Scientific reports. 2019 February;9:3035. [Full Text Article] [PubMed:30816200] [PMC:PMC6395665]

Effect of Maternal Obesity on Placental Lipid Metabolism. Calabuig-Navarro V, Haghiac M, Minium J, Glazebrook P, Ranasinghe GC, Hoppel C, Hauguel de-Mouzon S, Catalano P, O'Tierney-Ginn P. Endocrinology. 2017 August;158:2543-2555. [Full Text Article] [PubMed:28541534] [PMC:PMC5551552] Related Antibodies: LS-B4850.

Inhibition of ß-Catenin Signaling in the Skin Rescues Cutaneous Adipogenesis in Systemic Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Trial of C-82. Lafyatis R, Mantero JC, Gordon J, Kishore N, Carns M, Dittrich H, Spiera R, Simms RW, Varga J. The Journal of investigative dermatology. 2017 December;137:2473-2483. [Full Text Article] [PubMed:28807667] [PMC:PMC5701831] Related Antibodies: LS-B4850.

STK25 is a critical determinant in nonalcoholic steatohepatitis. Amrutkar M, Chursa U, Kern M, Nuñez-Durán E, Ståhlman M, Sütt S, Borén J, Johansson BR, Marschall HU, Blüher M, Mahlapuu M. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016 October;30:3628-3643. [Full Text Article] [PubMed:27421788]

Plin2-deficiency reduces lipophagy and results in increased lipid accumulation in the heart. Ismena Mardani, Knut Tomas Dalen, Christina Drevinge, Azra Miljanovic, Marcus Ståhlman, Martina Klevstig, Margareta Scharin Täng, Per Fogelstrand, Max Levin, Matias Ekstrand, Syam Nair, Björn Redfors, Elmir Omerovic, Linda Andersson, Alan R Kimmel, Jan Borén, Malin C Levin. Scientific reports. 2019 May;9:6909. [Full Text Article] [PubMed:31061399] [PMC:PMC6502866]

Immunohistochemistry in Investigative and Toxicologic Pathology. Kyathanahalli S Janardhan, Heather Jensen, Natasha P Clayton, Ronald A Herbert. Toxicologic pathology. 2018 July;46:488-510. [Full Text Article] [PubMed:29966501] [PMC:PMC6033701]

Ces1d deficiency protects against high-sucrose diet-induced hepatic triacylglycerol accumulation. Jihong Lian, Russell Watts, Ariel D Quiroga, Megan R Beggs, R Todd Alexander, Richard Lehner. Journal of lipid research. 2019 Apr;60:880-891. [Full Text Article] [PubMed:30737251] [PMC:PMC6446703]

Pregnancy and weaning regulate human maternal liver size and function10<sup> Mother Infant Research Institute, Department of Obstetrics and Gynecology, Tufts University School of Medicine, Boston, MA 0211112<sup> Department of Cell, Developmental, and Cancer Biology, Oregon Health & Science University, Portland, OR 97239; schedin@ohsu.edu14<sup> Young Women's Breast Cancer Translational Program, University of Colorado Anschutz Medical Campus, Aurora, CO 80045. Alexandra Q Bartlett, Kimberly K Vesco, Jonathan Q Purnell, Melanie Francisco, Erica Goddard, Xiangnan Guan, Andrea DeBarber, Michael C Leo, Eric Baetscher, William Rooney, Willscott Naugler, Alexander R Guimaraes, Patrick Catalano, Zheng Xia , Pepper Schedin. Proceedings of the National Academy of Sciences of the United States of America. 2021 Nov;118:e2107269118. [Full Text Article] [PubMed:34815335] [PMC:PMC8640831]

Preventing ovariectomy-induced weight gain decreases tumor burden in rodent models of obesity and postmenopausal breast cancer. Elizabeth A Wellberg, Karen A Corleto, L Allyson Checkley, Sonali Jindal, Ginger Johnson, Janine A Higgins, Sarina Obeid, Steven M Anderson, Ann D Thor, Pepper J Schedin, Paul S MacLean, Erin D Giles. Breast cancer research : BCR. 2022 June;24:42. [Full Text Article] [PubMed:35725493] [PMC:PMC9208221]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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