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Human group III secreted phospholipase A2 belongs to a superfamily of intracellular and secreted enzymes that catalyze the hydrolysis of glycerophospholipids at the sn-2 position to release fatty acids and lysophospholipids. Group III PLA2 enzymes were originally identified in invertebrates such as bees and scorpions. Human group III sPLA2 has been shown to be a calcium dependent enzyme. It consists of a central group III sPLA2 domain flanked by unique N- and C-terminal domains that are proteolytically removed in most tissues. The sPLA2 domain is sufficient for catalytic activity. SPLA2-III is preferentially expressed in the microvascular endothelium of tissues with inflammation, ischemic injury and cancer.
Gene Name: | phospholipase A2, group III |
Family/Subfamily: | Phospholipase , not assigned-Phospholipase |
Synonyms: | PLA2G3, GIII-SPLA2, Phospholipase A2, group III, SPLA2-III, GIII sPLA2, SPLA2III |
Target Sequences: | NM_015715 NP_056530.2 Q9NZ20 |
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