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PHLDA2 / TSSC3 is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver.
Gene Name: | pleckstrin homology-like domain, family A, member 2 |
Synonyms: | PHLDA2, BWR1C, IPL, HLDA2, p17-BWR1C, BRW1C, TSSC3, Tumor-supressing STF cDNA 3 |
Target Sequences: | NM_003311 NP_003302.1 Q53GA4 |
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