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SPARC (secreted protein acidic and rich in cysteine)/Osteonectin is a matricellular glycoprotein that modulates cellular interactions with the ECM and is expressed in tissues undergoing remodeling. It functions as a de-adhesive protein, as a modulator of growth factor activity, and as a cell-cycle inhibitor. It induces changes in endothelial cell shape via F-actin, coincident with the appearance of intercellular gaps, that provide a paracellular pathway for extravasation of macromolecules. Tumor growth is enhanced in mice lacking SPARC due to changes in the ECM that create a more permissive environment for tumor progression.
Gene Name: | secreted protein, acidic, cysteine-rich (osteonectin) |
Synonyms: | SPARC, Basement-membrane protein 40, BM-40, Cysteine-rich protein, ON, Osteonectin |
Target Sequences: | NM_003118 NP_003109.1 P09486 |
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