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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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OCLN / Occludin

occludin

OCLN / Occludin is an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Mutations in this gene are thought to be a cause of band-like calcification with simplified gyration and polymicrogyria (BLC-PMG), an autosomal recessive neurologic disorder that is also known as pseudo-TORCH syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene is present 1.5 Mb downstream on the q arm of chromosome 5.

Gene Name: occludin
Synonyms: OCLN, Occludin, BLCPMG
Target Sequences: NM_002538 NP_002529.1 Q16625

Publications (5)

1
The Semaphorin 4D-RhoA-Akt Signal Cascade Regulates Enamel Matrix Secretion in Coordination With Cell Polarization During Ameloblast Differentiation. Otsu K, Ida-Yonemochi H, Fujiwara N, Harada H. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016 November;31:1943-1954. (Human) [Full Text Article] [PubMed:27218883] Related Antibodies: LS-B2320.
2
TLR3 deficiency exacerbates the loss of epithelial barrier function during genital tract Chlamydia muridarum infection. Kumar R, Gong H, Liu L, Ramos-Solis N, Seye CI, Derbigny WA. PloS one. 2019 January;14:e0207422. [Full Text Article] [PubMed:30625140] [PMC:PMC6326510] Related Antibodies: LS-B2187.
3
The tight-junction protein claudin-6 induces epithelial differentiation from mouse F9 and embryonic stem cells. Sugimoto K, Ichikawa-Tomikawa N, Satohisa S, Akashi Y, Kanai R, Saito T, Sawada N, Chiba H. PloS one. 2013 8:e75106. [Full Text Article] [PubMed:24116027] [PMC:PMC3792957] Related Antibodies: LS-B2187.
4
ATF3 Protects Pulmonary Resident Cells from Acute and Ventilator-Induced Lung Injury by Preventing Nrf2 Degradation. Shan Y, Akram A, Amatullah H, Zhou DY, Gali PL, Maron-Gutierrez T, Gonz[Character e1]lez-L[Character f3]pez A, Zhou L, Rocco PR, Hwang D, Albaiceta GM, Haitsma JJ, Dos Santos CC. Antioxidants & redox signaling. 2014 Mar;22:651-68. [Full Text Article] [PubMed:25401197] [PMC:PMC4346377] Related Antibodies: LS-B2187.
5
Protective role of uncoupling protein-2 against dextran sodium sulfate-induced colitis. Zhang H, Kuai XY, Yu P, Lin L, Shi R. Journal of gastroenterology and hepatology. 2012 Mar;27:603-8. [Full Text Article] [PubMed:21871020] Related Antibodies: LS-C50519.
more

Viewing 1-9 of 9 items
OCLN / Occludin Protein - Purified recombinant protein OCLN was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc + DDK
59 kDa
20µg   0.221mg/ml   $890.00
OCLN / Occludin Protein - Recombinant Occludin By SDS-PAGE
Select
E. coli
His
11.8 kDa
10µg   $275.00; 50µg   $455.00; 100µg   $605.00; 200µg   $875.00; 1mg   $2,265.00; 500µg   $1,005.00
OCLN / Occludin Protein - 12.5% SDS-PAGE Stained with Coomassie Blue
Select
Wheat Germ Extract
GST,N-terminus
10µg   $425.00; 25µg   $590.00
Select
E. coli
GST,N-terminus
42 kDa
200µg   $315.00
OCLN / Occludin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc + DDK
59 kDa
20µg   $195.00
OCLN / Occludin Protein
Select
E. coli
His, N-Terminal
37 kDa
10µg   $215.00; 100µg   $325.00; 250µg   $485.00; 50µg   $265.00
OCLN / Occludin Protein - 12.5% SDS-PAGE of human OCLN stained with Coomassie Blue
Select
Wheat Germ Extract
GST
82.94 kDa
10µg   $425.00; 25µg   $590.00
OCLN / Occludin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc + DDK
59 kDa
100µg   $365.00
Select
E. coli
253 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
27.94 kDa
10mg   $4,800.00; 5mg   $3,600.00; 1mg   $2,100.00; 0.5mg   $1,530.00; 200µg   $1,035.00; 100µg   $695.00; 50µg   $485.00

Viewing 1-9 of 9 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).