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Unfortunately, the antibody (ID:211294) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



NTRK2 / TRKB

neurotrophic tyrosine kinase, receptor, type 2

Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.

Gene Name: neurotrophic tyrosine kinase, receptor, type 2
Family/Subfamily: Protein Kinase , Trk/Ror
Synonyms: NTRK2, gp145-TrkB, Trk-B, TRKB, Tropomyosin-related kinase B, TrkB tyrosine kinase, Tyrosine kinase receptor B
Target Sequences: NM_006180 NP_006171.2 Q16620

Publications (1)

1
Status epilepticus induces a TrkB to p75 neurotrophin receptor switch and increases brain-derived neurotrophic factor interaction with p75 neurotrophin receptor: an initial event in neuronal injury induction. Unsain N, Nuez N, Anastasa A, Masc DH. Neuroscience. 2008 154:978-93. (WB) [PubMed:18511210]

Filtered By: None
Target
ntrk2-trkb (95)
Reactivity
Human (76)
Mouse (57)
Rat (52)
Bovine (6)
Chicken (5)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Hamster (1)
Horse (6)
Monkey (11)
Pig (9)
Rabbit (8)
Xenopus (1)
Zebrafish (1)
Application
IHC (53)
IHC-P (16)
WB (78)
Flo (4)
ELISA (23)
ICC (4)
IF (12)
Peptide-ELISA (9)
Host
rabbit (83)
mouse (9)
goat (1)
sheep (2)
Isotype
IgG (53)
IgG1 (2)
IgG1,k (1)
IgG2a,k (1)
Clonality
monoclonal mc (10)
polyclonal pc (85)
Clone
10B6C4 (1)
1446CT494.85.83.49 (1)
4D3-F10 (1)
8D2E8 (1)
Format
AP Conjugated (2)
APC (1)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (5)
HRP Conjugated (4)
PE Conjugated (4)
Unconjugated (70)
Epitope
aa32-430 (10)
aa343-372 (8)
pTyr515 (5)
pTyr705 (5)
aa466-515 (4)
aa400-450 (3)
pTyr706 (3)
C-Terminus (2)
Pro50 (2)
pTyr516 (2)
pTyr816 (2)
Asp699 (1)
Cytoplasmic Domain (1)
Extracellular Domain (1)
Internal (1)
Val509 (1)
aa1-429 (1)
aa160-172 (1)
aa32-282 (1)
aa32-80 (1)
aa450-530 (1)
aa481-530 (1)
aa54-67 (1)
aa640-720 (1)
aa66-242 (1)
aa671-720 (1)
aa70-90 (1)
aa703-707 (1)
aa768-817 (1)
aa770-821 (1)
pTyr706, pTyr707 (1)
pTyr706/707 (1)
pTyr817 (1)
Publications
No (95)
Showing 1-25 out of 95 results
Anti-NTRK2 / TRKB Antibody (Cytoplasmic Domain) IHC-plus™ LS-A9401
Anti-NTRK2 / TRKB antibody LS-A9401 IHC of human brain, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Rabbit Polyclonal to Human NTRK2 / TRKB
Rabbit, Horse, Human, Monkey
IHC IHC-P
Unconjugated
Anti-NTRK2 / TRKB Antibody (aa1-429) IHC-plus™ LS-B2544
Anti-NTRK2 / TRKB antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2544 concentration 10 ug/ml.

Rabbit Polyclonal (IgG) to Rat NTRK2 / TRKB
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (Pro50) LS-C39859

Rabbit Monoclonal (IgG) to Human NTRK2 / TRKB
Human
ELISA Flo IHC IHC-P
Unconjugated
Anti-NTRK2 / TRKB Antibody LS-C48549
Western blot of TRKB / TRK B antibody LS-C48549.

Rabbit Polyclonal to Human NTRK2 / TRKB
Chicken, Mouse, Rat, Human
IF WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (phospho-Tyr705) LS-C89740

Rabbit Polyclonal (IgG) to Human NTRK2 / TRKB
Xenopus, Chicken, Zebrafish, Horse, Rat, Hamster, Rabbit, Mouse, Dog, Human, Monkey
WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (C-Terminus) LS-C136921
Immunofluorescence Image

Rabbit Polyclonal to Human NTRK2 / TRKB
Human
ELISA IF
Unconjugated
Anti-NTRK2 / TRKB Antibody (aa400-450) LS-C95066

Rabbit Polyclonal (IgG) to Rat NTRK2 / TRKB
Mouse, Rat
IHC WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (aa400-450) LS-C94983

Sheep Polyclonal (IgG) to Rat NTRK2 / TRKB
Mouse, Rat
IHC WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (aa343-372) LS-C329928

Rabbit Polyclonal (IgG) to Mouse NTRK2 / TRKB
Mouse, Human
ELISA IHC WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (aa343-372, APC) LS-C264825

Rabbit Polyclonal (IgG) to Mouse NTRK2 / TRKB
Mouse
ELISA IHC WB
APC Conjugated
Anti-NTRK2 / TRKB Antibody (aa343-372) LS-C164509
Mouse Ntrk2 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded mouse brain tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Western blot of lysate from mouse NIH/3T3 cell line, using Mouse Ntrk2 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.

Rabbit Polyclonal to Mouse NTRK2 / TRKB
Mouse
IHC IHC-P WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (aa770-821) LS-C95157

Rabbit Polyclonal (IgG) to Human NTRK2 / TRKB
Mouse, Rat, Human
IHC WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (phospho-Tyr816) LS-C95153

Rabbit Polyclonal (IgG) to Human NTRK2 / TRKB
Mouse, Rat, Human
IHC WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (aa481-530) IHC-plus™ LS-B8691
Anti-NTRK2 / TRKB antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Western blot of extracts from rat brain/mouse brain cells, treated with PBS 60', using Trk B (Ab-515) Antibody. The lane on the right is treated with the synthesized peptide.

Rabbit Polyclonal (IgG) to Human NTRK2 / TRKB
Mouse, Rat, Human
IHC IHC-P Peptide-ELISA WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (Pro50) LS-C76579

Rabbit Monoclonal (IgG) to Human NTRK2 / TRKB
WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (phospho-Tyr705) LS-C416833
Western blot of Trk B phosphorylation expression in Mouse kidney tissue lysates,The lane on the left is treated with the antigen-specific peptide.

Rabbit Polyclonal to Human NTRK2 / TRKB
Mouse, Rat, Human
ICC IF IHC WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (phospho-Tyr705) LS-C199687
IHC of paraffin-embedded human brain, using Trk B (Phospho-Tyr705) Antibody. The sample on the right was incubated with synthetic peptide.
Immunofluorescence of HUVEC cells, using Trk B (Phospho-Tyr705) Antibody. The sample on the right was incubated with synthetic peptide.

Rabbit Polyclonal (IgG) to Human NTRK2 / TRKB
Mouse, Rat, Human
IF IHC IHC-P Peptide-ELISA WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (phospho-Tyr706) LS-C380863
Western blot of Phospho-Trk B (Y706) antibody

Rabbit Polyclonal (IgG) to Human NTRK2 / TRKB
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (aa450-530) LS-C386519
Western blot of Trk B antibody
Western blot of Trk B antibody

Rabbit Polyclonal (IgG) to Human NTRK2 / TRKB
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
Anti-NTRK2 / TRKB Antibody LS-C393416

Rabbit Polyclonal to Human NTRK2 / TRKB
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (phospho-Tyr706) LS-C177968
IHC of p-Trk B (Y706) pAb in paraffin-embedded human brain tissue.
Western blot of p-Trk B (Y706) pAb in extracts from mouse kidney cells.

Rabbit Polyclonal to Human NTRK2 / TRKB
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (clone 10B6C4) LS-C669352

Mouse Monoclonal [clone 10B6C4] (IgG1) to Human NTRK2 / TRKB
Human
ELISA IHC WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (Internal) LS-C352613
Immunofluorescent analysis of TRK B staining in HL60 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Western blot analysis of TRK B expression in HL60 (A); SKNSH (B); mouse brain (C) whole cell lysates.

Rabbit Polyclonal to Human NTRK2 / TRKB
Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Human, Monkey
ICC IF WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (phospho-Tyr515) LS-C357115
Immunohistochemical of paraffin-embedded human brain tissue using Trk B (phospho-Tyr515) antibody.
Western blot of extracts from K562 cells (Lane 2) and 3T3 cells (Lane 3), using Trk(Phospho-Tyr515) Antibody. The lane on the left is treated with synthesized peptide.

Rabbit Polyclonal to Human NTRK2 / TRKB
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
Anti-NTRK2 / TRKB Antibody (phospho-Tyr516) LS-C380862
Western blot of Phospho-Trk B (Y516) antibody

Rabbit Polyclonal (IgG) to Human NTRK2 / TRKB
Mouse, Rat, Human
ELISA IHC WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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