NR0B2

nuclear receptor subfamily 0, group B, member 2

SHP (short heterodimer partner) is a bile acid-dependent orphan NR0 Knirps-Like receptor with dimerization and ligand-binding domains but not the conventional DNA-binding domain. SHP has been shown to inhibit the transcriptional activity of other nuclear receptors, including thyroid hormone receptor, constitutive androstane receptor, and retinoic acid receptors. SHP affects hepatic cholesterol catabolism based on a two-step mechanism dependent on both coactivator competition and direct transcriptional repression by mediating the repression of CYP7A1, the rate-limiting enzyme for bile acid synthesis. Mutations in the SHP gene contribute to increased body weight, indicating a possible role of SHP in the development of early-onset diabetes (maturity-onset diabetes of the young, MODY). Loss of SHP in mice caused abnormal accumulation and increased synthesis of bile acids due to derepression of rate-limiting CYP7A1 and CYP8B1 hydroxylase enzymes in the biosynthetic pathway.

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Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

NR0B2 (6)

Publications

No (6)

Tag

GST (1)

His, N-Terminal (1)

His-T7 (2)

Myc-DDK (Flag) (2)

Species

Human (4)

Rat (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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NR0B2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101778

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.9 kDa

Price:

100 µg/$494

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Human NR0B2 Protein (Recombinant His-T7) (aa1-257) - LS-G24730

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.8 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Rat NR0B2 Protein (Recombinant His-T7) (aa1-260) - LS-G24731

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.5 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$707; 200 µg/$885; 1 mg/$1,994; 500 µg/$1,534; 5 mg/$3,095; 2 mg/$2,181

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Human NR0B2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G82530

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

27.9 kDa

Price:

20 µg/$150

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Human NR0B2 Protein (Recombinant His, N-Terminal) - LS-G143978

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

28.1 kDa

Price:

50 µg/$419

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Human NR0B2 Protein (Recombinant GST) (Full Length) - LS-G31146

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

54.01 kDa

Price:

2 µg/$439

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