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Catalog Number Size Price
LS-A5411-50 50 µg (1 mg/ml) $440 
NR0B2 Antibody - Ovary, carcinoma
NR0B2 Antibody - Pancreas, carcinoma
NR0B2 Antibody - Anti-NR0B2 antibody IHC of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NR0B2 Antibody - Breast, carcinoma
NR0B2 Antibody - Ovary, carcinoma
NR0B2 Antibody - Pancreas, carcinoma
NR0B2 Antibody - Anti-NR0B2 antibody IHC of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
NR0B2 Antibody - Breast, carcinoma
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PathPlus™ Polyclonal Rabbit anti‑Human NR0B2 Antibody (Ligand‑binding Domain, IHC, IF) LS‑A5411

PathPlus™ Polyclonal Rabbit anti‑Human NR0B2 Antibody (Ligand‑binding Domain, IHC, IF) LS‑A5411

Antibody:
NR0B2 Rabbit anti-Human Polyclonal (Ligand-binding Domain) Antibody
Application:
IHC, IHC-P, ICC, IF
Reactivity:
Human, Monkey, Mouse, Hamster, Rabbit
Format:
Unconjugated, Unmodified
Other formats:
Price
Catalog Number
$440
LS-A5411-50

Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
NR0B2 Rabbit anti-Human Polyclonal (Ligand-binding Domain) Antibody
Application:
IHC, IHC-P, ICC, IF
Reactivity:
Human, Monkey, Mouse, Hamster, Rabbit
Format:
Unconjugated, Unmodified
Other formats:

Specifications

Description
SHP (short heterodimer partner) is a bile acid-dependent orphan NR0 Knirps-Like receptor with dimerization and ligand-binding domains but not the conventional DNA-binding domain. SHP has been shown to inhibit the transcriptional activity of other nuclear receptors, including thyroid hormone receptor, constitutive androstane receptor, and retinoic acid receptors. SHP affects hepatic cholesterol catabolism based on a two-step mechanism dependent on both coactivator competition and direct transcriptional repression by mediating the repression of CYP7A1, the rate-limiting enzyme for bile acid synthesis. Mutations in the SHP gene contribute to increased body weight, indicating a possible role of SHP in the development of early-onset diabetes (maturity-onset diabetes of the young, MODY). Loss of SHP in mice caused abnormal accumulation and increased synthesis of bile acids due to derepression of rate-limiting CYP7A1 and CYP8B1 hydroxylase enzymes in the biosynthetic pathway. References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human NR0B2
Synonyms
NR0B2 | Short heterodimer partner | SHP | Nuclear receptor SHP | Orphan nuclear receptor SHP | Small heterodimer partner | SHP1
Host
Rabbit
Reactivity
Human, Monkey, Mouse, Hamster, Rabbit (tested or 100% immunogen sequence identity)
Predicted
Rat, Bat, Bovine (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 16 amino acid peptide from ligand-binding domain of human NR0B2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Hamster, Rabbit (100%); Rat, Bovine, Bat (94%); Elephant, Panda, Horse, Pig, Opossum (88%); Dog (81%).
Epitope
Ligand-binding Domain
Specificity
Human NR0B2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
  • IHC
  • IHC - Paraffin (4 µg/ml)
  • ICC
  • Immunofluorescence
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About NR0B2
Q15466 NM_021969 NP_068804.1

Validation

NR0B2 Antibody - Ovary, carcinoma
Ovary, carcinoma
Ovary, carcinoma

NR0B2 Antibody - Pancreas, carcinoma
Pancreas, carcinoma
Pancreas, carcinoma

NR0B2 Antibody - Anti-NR0B2 antibody IHC of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NR0B2 antibody IHC of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NR0B2 antibody IHC of human liver, hepatocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

NR0B2 Antibody - Breast, carcinoma
Breast, carcinoma
Breast, carcinoma

LSBio Ratings

PathPlus™ NR0B2 Antibody (Ligand-binding Domain) for IHC, ICC, IF/Immunofluorescence LS-A5411 has an LSBio Rating of
Publications (4.2)
Laboratory Validation Score (5)

Publications (3)

Nuclear receptor SHP, a death receptor that targets mitochondria, induces apoptosis and inhibits tumor growth. Zhang Y, Soto J, Park K, Viswanath G, Kuwada S, Abel ED, Wang L. Molecular and cellular biology. 2010 30:1341-56. (ICC, WB; Mouse, Human)

Cellular distributions of molecules with altered expression specific to the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model. Takahashi M, Shibutani M, Woo GH, Inoue K, Fujimoto H, Igarashi K, Kanno J, Hirose M, Nishikawa A. Carcinogenesis. 2008 Nov;29:2218-26.

Epigenetic inhibition of nuclear receptor small heterodimer partner is associated with and regulates hepatocellular carcinoma growth. He N, Park K, Zhang Y, Huang J, Lu S, Wang L. Gastroenterology. 2008 Mar;134:793-802.

Customer Reviews (0)


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Requested From: United States
Date Requested: 9/27/2021