The Neuropeptide FF 2 Receptor (NPFF2/HLWAR77/NPGPR) is a Neuropeptide Receptor GPCR. This receptor has high affinity for NPAF and NPFF, and is also weakly activated by FMRF-amide (Phe-Met-Arg-Phe-amide) and a variety of related peptides. The receptor is expressed in brain regions associated with opiate activity, consistent with the pain-modulating activity of these peptides, and in adipose tissue, suggesting other physiological and pathophysiological activities for FMRF-amide neuropeptides (Elshourbagy et al, 2000). Four isoforms are produced by alternative splicing.
|Gene Name:||neuropeptide FF receptor 2|
|Family/Subfamily:||GPCR , Neuropeptide|
|Synonyms:||NPFFR2, G protein-coupled receptor 74, HLWAR77, G-protein coupled receptor 74, Neuropeptide FF receptor 2, Neuropeptide FF 2, NPFF2, Neuropeptide FF 2 receptor, NPGPR, GPR74, NPFF-R2, NPFF2 receptor, NPGP receptor|
|Target Sequences:||NM_004885 NP_004876.2 Q9Y5X5|
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