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NPFF2 / NPFFR2

neuropeptide FF receptor 2

The Neuropeptide FF 2 Receptor (NPFF2/HLWAR77/NPGPR) is a Neuropeptide Receptor GPCR. This receptor has high affinity for NPAF and NPFF, and is also weakly activated by FMRF-amide (Phe-Met-Arg-Phe-amide) and a variety of related peptides. The receptor is expressed in brain regions associated with opiate activity, consistent with the pain-modulating activity of these peptides, and in adipose tissue, suggesting other physiological and pathophysiological activities for FMRF-amide neuropeptides (Elshourbagy et al, 2000). Four isoforms are produced by alternative splicing.

Gene Name: neuropeptide FF receptor 2
Family/Subfamily: GPCR , Neuropeptide
Synonyms: NPFFR2, G protein-coupled receptor 74, HLWAR77, G-protein coupled receptor 74, Neuropeptide FF receptor 2, Neuropeptide FF 2, NPFF2, Neuropeptide FF 2 receptor, NPGPR, GPR74, NPFF-R2, NPFF2 receptor, NPGP receptor
Target Sequences: NM_004885 NP_004876.2 Q9Y5X5

Publications (2)

1
Neuropeptide FF activates ERK and NF kappa B signal pathways in differentiated SH-SY5Y cells. Sun YL, Zhang XY, He N, Sun T, Zhuang Y, Fang Q, Wang KR, Wang R. Peptides. 2012 38:110-7. (ICC, WB; Human) [PubMed:22981806]
2
Multiple primary cilia modulate the fluid transcytosis in choroid plexus epithelium. Narita K, Kawate T, Kakinuma N, Takeda S. Traffic (Copenhagen, Denmark). 2010 Feb;11:287-301. [Full Text Article] [PubMed:19958467] Related Antibodies: LS-A463.

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Antibodies (25)
Primary (25)
NPFF2 / NPFFR2 (25)
Human (23)
Mouse (4)
Rat (3)
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Gibbon (3)
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IHC (6)
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rabbit (24)
rabbit-new zealand white (1)
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polyclonal pc (25)
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Azide-free (1)
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Unconjugated (14)
aa3-32 (7)
C-Terminus (5)
aa251-300 (4)
aa291-308 (2)
Extracellular Domain (1)
N-Terminus (1)
aa350-415 (1)
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Yes (1)
NPFF2 / NPFFR2 Antibody - Brain , Medulla
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Neuroscience
NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
NPFF2 / NPFFR2 Antibody - Anti-NPFF2 / NPFFR2 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 4-7 ug/ml.
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
NPFF2 / NPFFR2 Antibody - Western blot analysis of extracts of various cell lines, using NPFFR2 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
NPFF2 / NPFFR2 Antibody - NPFFR2 antibody Western blot of Jurkat lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (aa251-300) Antibody
Human
WB
Unconjugated
100 µl/$424
NPFF2 / NPFFR2 Antibody - NPFFR2 antibody Western blot of Jurkat lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (aa251-300) (HRP) Antibody
Bovine, Horse, Human
WB
HRP Conjugated
100 µl/$469
NPFF2 / NPFFR2 Antibody - NPFFR2 antibody Western blot of Jurkat lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (aa251-300) (Biotin) Antibody
Bovine, Horse, Human
WB
Biotin Conjugated
100 µl/$469
NPFF2 / NPFFR2 Antibody - NPFFR2 antibody Western blot of Jurkat lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (aa251-300) (FITC) Antibody
Bovine, Horse, Human
WB
FITC Conjugated
100 µl/$469
NPFF2 / NPFFR2 Antibody - Anti-NPFFR2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Horse, Human
IHC, IHC-P
Unconjugated
50 µg/$460
NPFF2 / NPFFR2 Antibody - NPFFR2 Antibody western blot of NCI-H460 cell line lysates (35 ug/lane). The NPFFR2 antibody detected the NPFFR2 protein (arrow).
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (aa3-32) Antibody
Human
WB
Unconjugated
400 µl/$393
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NPFF2 / NPFFR2 Rabbit-New Zealand White anti-Mouse Polyclonal (aa350-415) Antibody
Mouse
IHC, WB
Unconjugated
100 µl/$393
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (aa291-308) Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
100 µl/$783
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
100 µg/$351
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (aa3-32) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (aa3-32) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (aa3-32) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (aa3-32) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (aa3-32) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (aa3-32) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$475
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (aa291-308) Antibody
Human
ELISA
Unconjugated
200 µg/$1,027
NPFF2 / NPFFR2 Antibody - NPFFR2 antibody Western blot of THP-1 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
NPFF2 / NPFFR2 Antibody - NPFFR2 antibody Western blot of THP-1 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human, Monkey, Gibbon
WB
HRP Conjugated
100 µl/$469
NPFF2 / NPFFR2 Antibody - NPFFR2 antibody Western blot of THP-1 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human, Monkey, Gibbon
WB
Biotin Conjugated
100 µl/$469
NPFF2 / NPFFR2 Antibody - NPFFR2 antibody Western blot of THP-1 cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPFF2 / NPFFR2 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human, Monkey, Gibbon
WB
FITC Conjugated
100 µl/$469
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