Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.
NPFF2 / NPFFR2
neuropeptide FF receptor 2
The Neuropeptide FF 2 Receptor (NPFF2/HLWAR77/NPGPR) is a Neuropeptide Receptor GPCR. This receptor has high affinity for NPAF and NPFF, and is also weakly activated by FMRF-amide (Phe-Met-Arg-Phe-amide) and a variety of related peptides. The receptor is expressed in brain regions associated with opiate activity, consistent with the pain-modulating activity of these peptides, and in adipose tissue, suggesting other physiological and pathophysiological activities for FMRF-amide neuropeptides (Elshourbagy et al, 2000). Four isoforms are produced by alternative splicing.
Neuropeptide FF activates ERK and NF kappa B signal pathways in differentiated SH-SY5Y cells. Sun YL, Zhang XY, He N, Sun T, Zhuang Y, Fang Q, Wang KR, Wang R. Peptides. 2012 38:110-7. (ICC, WB; Human)
Multiple primary cilia modulate the fluid transcytosis in choroid plexus epithelium. Narita K, Kawate T, Kakinuma N, Takeda S. Traffic (Copenhagen, Denmark). 2010 Feb;11:287-301. [Full Text Article]
Related Antibodies: LS-A463.