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MTOR

mechanistic target of rapamycin (serine/threonine kinase)

Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP. mTORC1 exerts a feedback control on upstream growth factor signaling that includes phosphorylation and activation of GRB10 a INSR-dependent signaling suppressor. Among other potential targets mTORC1 may phosphorylate CLIP1 and regulate microtubules. As part of the mTORC2 complex MTOR may regulate other cellular processes including survival and organization of the cytoskeleton. Plays a critical role in the phosphorylation at 'Ser-473' of AKT1, a pro-survival effector of phosphoinositide 3-kinase, facilitating its activation by PDK1. mTORC2 may regulate the actin cytoskeleton, through phosphorylation of PRKCA, PXN and activation of the Rho-type guanine nucleotide exchange factors RHOA and RAC1A or RAC1B. mTORC2 also regulates the phosphorylation of SGK1 at 'Ser-422'.

Gene Name: mechanistic target of rapamycin (serine/threonine kinase)
Family/Subfamily: Protein Kinase , PI3/PI4
Synonyms: MTOR, FRAP1, FRAP2, FRAP, Mammalian target of rapamycin, RAFT1, Rapamycin and FKBP12 target 1, RAPT1, Rapamycin target protein 1
Target Sequences: NM_004958 NP_004949.1 P42345

Publications (1)

1
The role of mTOR and phospho-p70S6K in pathogenesis and progression of gastric carcinomas: an immunohistochemical study on tissue microarray. Xiao L, Wang YC, Li WS, Du Y. Journal of experimental & clinical cancer research : CR. 2009 28:152. (IHC) [PubMed:20003385] [PMC:PMC2797794]

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Antibodies (145)
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MTOR (145)
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No (145)
MTOR Antibody - Anti-MTOR antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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MTOR Rabbit anti-Human Polyclonal (pSer2448) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$625
MTOR Antibody - Anti-MTOR antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Cancer
MTOR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$485
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MTOR Rabbit anti-Human Polyclonal (aa1350-1400) Antibody
Mouse, Human
IP, WB
Unconjugated
100 µl/$457
MTOR Antibody - Anti-MTOR antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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MTOR Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IHC, IHC-P, WB
Unconjugated
0.05 mg/$555
MTOR Antibody - Anti-MTOR antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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MTOR Rabbit anti-Human Polyclonal (Ser2442) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, WB
Unconjugated
50 µl/$535
MTOR Antibody - Immunohistochemical analysis of mTOR (pS2448) staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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MTOR Rabbit anti-Human Polyclonal (pS2448) Antibody
Mouse, Sheep, Rat, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
30 µl/$253; 100 µl/$305; 200 µl/$369
MTOR Antibody - mTOR antibody for IHC in human prostate tissue
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MTOR Rabbit anti-Human Polyclonal Antibody
Fish, Rat, Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
MTOR Antibody - Western blot of mTOR phosphorylation expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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MTOR Rabbit anti-Human Polyclonal (pSer2481) Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$347
MTOR Antibody - Formalin-fixed and paraffin-embedded human testis tissue reacted with FRAP1-pS2481, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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MTOR Rabbit anti-Human Polyclonal (Ser2481) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$381
MTOR Antibody - IHC of paraffin-embedded Carcinoma of Human liver tissue using anti-MTOR mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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MTOR Mouse anti-Human Monoclonal (aa1766-2144) (OTI3E5) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$409
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MTOR Rat anti-Human Monoclonal Antibody
Mouse, Human
ELISA, ICC
Unconjugated
100 µg/$716
MTOR Antibody - Human Lung, Respiratory Epithelium: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer
MTOR Mouse anti-Human Monoclonal (aa1766-2144) (10B4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$545
MTOR Antibody - Detection limit for recombinant GST tagged MTOR is approximately 3 ng/ml as a capture antibody.
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MTOR Mouse anti-Human Monoclonal (2C5) Antibody
Human
ELISA
Unconjugated
100 µg/$407
MTOR Antibody - Western blot of Phospho-mTOR (S2448) antibody
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MTOR Rabbit anti-Human Polyclonal (pS2448) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
MTOR Antibody - Anti-MTOR antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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MTOR Rabbit anti-Human Polyclonal (aa2447-2496) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$505
MTOR Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using mTOR (Phospho-Ser2481) Antibody. The picture on the right is blocked with the phospho peptide.
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MTOR Rabbit anti-Human Polyclonal (pSer2481) Antibody
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$306; 100 µl/$366
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MTOR Rabbit anti-Human Monoclonal (Ser2448) (D9C2) Antibody
Mouse, Rat, Human
IF, IP, WB
Unconjugated
20 µl/$459; 100 µl/$728
MTOR Antibody - IHC of p-mTOR (S2448) pAb in paraffin-embedded human brain tissue.
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MTOR Rabbit anti-Human Polyclonal (pSer2448) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$327; 100 µl/$409
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MTOR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$479
MTOR Antibody - Western blot analysis of lysates from NIH/3T3 cells treated with Insulin 0.01U/ml 15', using mTOR (Phospho-Thr2446) Antibody. The lane on the right is blocked with the phospho peptide.
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MTOR Rabbit anti-Human Polyclonal (pThr2446) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$306; 100 µl/$366
MTOR Antibody - Anti-MTOR antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Cancer
MTOR Rabbit anti-Human Polyclonal (aa2415-2464) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µl/$460
MTOR Antibody - Western blot of mTOR antibody
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MTOR Rabbit anti-Human Polyclonal (2390-2470 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
MTOR Antibody - 1/100 staining human brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary antibody.
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MTOR Rabbit anti-Human Polyclonal (pSer2481) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µl/$369; 200 µl/$411
MTOR Antibody - Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MTOR Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$440
MTOR Antibody - Immunohistochemistry of paraffin-embedded rat ovary using mTOR antibody at dilution of 1:150 (40x lens).
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MTOR Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
20 µl/$253; 50 µl/$279; 100 µl/$333; 200 µl/$429
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).