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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MMP2

matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Gene Name: matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Family/Subfamily: Protease , Metallopeptidase M10A
Synonyms: MMP2, 72 kd type iv collagenase, 72 kDa gelatinase, 72 kd gelatinase, 72 kDa type IV collagenase, CLG4A, CLG4, GelA, Gelatinase A, Matrix metalloproteinase-2, MMP-2, MONA, Neutrophil gelatinase, TBE-1, Tbe-1 metalloprotease, Matrix metalloproteinase-II, MMP-II
Target Sequences: NM_004530 NP_004521.1 P08253

Publications (17)

1
The acute-phase response protects mice from D-galactosamine sensitization to endotoxin and tumor necrosis factor-alpha. Alcorn JM, Fierer J, Chojkier M. Hepatology (Baltimore, Md.). 1992 15:122-9. (WB; Human) [PubMed:1727788]
2
Differences in proliferation and invasion by normal, transformed and NF1 Schwann cell cultures are influenced by matrix metalloproteinase expression. Muir D. Clinical & experimental metastasis. 1995 13:303-14. [PubMed:7606893]
3
Neuronal matrix metalloproteinase-2 degrades and inactivates a neurite-inhibiting chondroitin sulfate proteoglycan. Zuo J, Ferguson TA, Hernandez YJ, Stetler-Stevenson WG, Muir D. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1998 18:5203-11. (Chicken) [PubMed:9651203]
4
MMP-2 and MMP-9 increase the neurite-promoting potential of schwann cell basal laminae and are upregulated in degenerated nerve. Ferguson TA, Muir D. Molecular and cellular neurosciences. 2000 16:157-67. (WB; Mouse) [PubMed:10924258]
5
Computed tomographic images reflect the biologic behavior of small lung adenocarcinoma: they correlate with cell proliferation, microvascularization, cell adhesion, degradation of extracellular matrix, and K-ras mutation. Dong B, Sato M, Sakurada A, Sagawa M, Endo C, Wu S, Yamanaka S, Horii A, Kondo T. The Journal of thoracic and cardiovascular surgery. 2005 130:733-9. (IHC-P; Human) [PubMed:16153921]
6
Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line. Wang XM, Yu DM, McCaughan GW, Gorrell MD. Hepatology (Baltimore, Md.). 2005 42:935-45. [PubMed:16175601]
7
Acetaminophen attenuates peroxynitrite-activated matrix metalloproteinase-2-mediated troponin I cleavage in the isolated guinea pig myocardium. Rork TH, Hadzimichalis NM, Kappil MA, Merrill GF. Journal of molecular and cellular cardiology. 2006 40:553-61. [PubMed:16530785]
8
Vascular endothelial growth factor expression in the basal subtype of breast carcinoma. Ribeiro-Silva A, Ribeiro do Vale F, Zucoloto S. American journal of clinical pathology. 2006 125:512-8. (IHC-P; Human) [PubMed:16627261]
9
Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease. Locke NR, Royce SG, Wainewright JS, Samuel CS, Tang ML. American journal of respiratory cell and molecular biology. 2007 36:625-32. (IHC-P; Mouse) [PubMed:17237192]
10
Nm23-H1 suppresses tumor cell motility by down-regulating the lysophosphatidic acid receptor EDG2. Horak CE, Lee JH, Elkahloun AG, Boissan M, Dumont S, Maga TK, Arnaud-Dabernat S, Palmieri D, Stetler-Stevenson WG, Lacombe ML, Meltzer PS, Steeg PS. Cancer research. 2007 67:7238-46. (WB; Human) [PubMed:17671192]
11
Microscopic mammalian retinal pigment epithelium lesions induce widespread proliferation with differences in magnitude between center and periphery. von Leithner PL, Ciurtin C, Jeffery G. Molecular vision. 2010 16:570-81. (ICC, IHC; Rat) [PubMed:20360994] [PMC:PMC2847682]
12
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S. Proceedings of the National Academy of Sciences of the United States of America. 2010 107:10649-54. (IHC) [PubMed:20498063] [PMC:PMC2890809]
13
Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats. Raaf L, Noll C, Cherifi, Samuel JL, Delcayre C, Delabar JM, Benazzoug Y, Janel N. Molecular and cellular biochemistry. 2011 347:63-70. (WB; Mouse) [PubMed:20938722]
14
Matrix metalloproteinase-2 and -9 activities in the human lens epithelial cells and serum of steroid induced posterior subcapsular cataracts. Alapure BV, Praveen MR, Gajjar DU, Vasavada AR, Parmar TJ, Arora AI. Molecular vision. 2012 18:64-73. [PubMed:22259225] [PMC:PMC3260085]
15
A Chinese herbal formula "Gan-Lu-Yin" suppresses vascular smooth muscle cell migration by inhibiting matrix metalloproteinase-2/9 through the PI3K/AKT and ERK signaling pathways. Chien YC, Sheu MJ, Wu CH, Lin WH, Chen YY, Cheng PL, Cheng HC. BMC complementary and alternative medicine. 2012 12:137. (WB; Rat) [PubMed:22920190] [PMC:PMC3475136]
16
Targeting L1 cell adhesion molecule expression using liposome-encapsulated siRNA suppresses prostate cancer bone metastasis and growth. Sung SY, Wu IH, Chuang PH, Petros JA, Wu HC, Zeng HJ, Huang WC, Chung LW, Hsieh CL. Oncotarget. 2014 5:9911-29. (IHC; Human) [Full Text Article] [PubMed:25294816] [PMC:PMC4259447]
17
Chlorogenic acid ameliorates brain damage and edema by inhibiting matrix metalloproteinase-2 and 9 in a rat model of focal cerebral ischemia. Lee K, Lee JS, Jang HJ, Kim SM, Chang MS, Park SH, Kim KS, Bae J, Park JW, Lee B, Choi HY, Jeong CH, Bu Y. European journal of pharmacology. 2012 Aug;689:89-95. [Full Text Article] [PubMed:22659584] Related Antibodies: LS-B2799.
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Filtered by: None
Target
MMP2 (193)
Reactivity
Human (170)
Mouse (60)
Rat (78)
Bat (3)
Bovine (21)
Cat (1)
Chicken (5)
Dog (12)
Gibbon (3)
Guinea pig (6)
Hamster (3)
Horse (5)
Monkey (10)
Pig (20)
Primate (1)
Rabbit (3)
Sheep (7)
Xenopus (3)
Zebrafish (3)
Application
IHC (61)
IHC-Fr (18)
IHC-P (19)
WB (162)
ELISA (64)
ICC (2)
IF (14)
IP (31)
Peptide-ELISA (1)
Host
rabbit (116)
mouse (76)
chicken (1)
Isotype
IgG (65)
IgG,k (3)
IgG1 (37)
IgG1,k (29)
IgG2a (4)
IgG2b,k (1)
Clonality
monoclonal mc (76)
polyclonal pc (117)
Clone
1H1 (1)
2C1 (1)
42-5D11 (1)
4D1E2 (2)
4D3 (2)
A-Gel VC2 (3)
CA-4001 or CA719E3C (3)
MMP2/1501 (2)
MMP2/2C1 (5)
OTI4A11 (2)
OTI4B11 (2)
SB13a (2)
SPM346 (1)
VB3 (3)
Format
AP Conjugated (9)
APC (4)
APC Conjugated (13)
Azide-free (4)
Biotin Conjugated (21)
Carrier-free (2)
Concentrated (1)
Cy3 Conjugated (4)
Cy7 Conjugated (4)
DY488 Conjugated (2)
DY550 Conjugated (2)
DY650 Conjugated (2)
FITC Conjugated (16)
HRP Conjugated (17)
PE Conjugated (13)
Unconjugated (90)
Epitope
aa110-660 (8)
aa303-331 (8)
aa445-660 (8)
C-Terminus (6)
aa475-490 (5)
aa110-662 (4)
aa228-507 (4)
APMA-Activated (3)
aa30-40 (3)
N-Terminus (2)
aa468-483 (2)
580-660 aa, C-terminal (1)
Amino Acid: 242-396 (1)
Hinge region (1)
Leu638 (1)
aa193-575 (1)
aa35-117 (1)
aa550-600 (1)
aa611-660 (1)
Publications
No (192)
Yes (1)
Showing 1-25 of 193 results

IHC-plus™ MMP2 Antibody (aa475-490) LS-B2799
Publications (1)
Publications (1)
Rabbit Polyclonal to Human MMP2
Chicken, Mouse, Guinea pig, Rat, Human
IHC, IHC-Fr, IHC-P, WB
Unconjugated
100µl 1mg/ml  $425.00
Anti-MMP2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of MMP2 in a Western blot of recombinant MMP2 and injured rat nerve lysate using  MMP2 Antibody. This image was taken for the unconjugated form of this product. Other forms have not been tested.

MMP2 Antibody (aa475-490, Biotin) LS-C142016
Rabbit Polyclonal to Human MMP2
Chicken, Mouse, Guinea pig, Rat, Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Biotin Conjugated
100µl 0.9mg/ml  $365.00
Anti-MMP2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Detection of MMP2 in a paraffin-embedded human neurofibroma section. Stained using MMP-2 Antibody Rabbit Polyclonal anti-MMP-2 (MMP2/475).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

IHC-plus™ MMP2 Antibody (aa468-483) LS-B2641
Mouse Monoclonal (IgG1,k) to Human MMP2
Pig, Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50µg 1mg/ml  $485.00
Anti-MMP2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

MMP2 Antibody (C-Terminus) LS-C352523
Rabbit Polyclonal to Human MMP2
Mouse, Dog, Bovine, Rat, Pig, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $245.00
Immunohistochemical analysis of MMP2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of MMP2 staining in COLO205 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

MMP2 Antibody (clone SB13a) LS-C149696
Mouse Monoclonal [clone SB13a] (IgG1) to Human MMP2
Human
ELISA, IHC, IHC-Fr, IHC-P
Unconjugated
0.1mg 0.5mg/ml  $315.00

MMP2 Antibody (clone 4D3) LS-C27029
Mouse Monoclonal [clone 4D3] (IgG1) to Human MMP2
Human
ELISA, IHC, WB
Unconjugated
200µg 1.27mg/ml  $355.00
A. IHC of human esophageal adenocarcinoma tissue using MMP-2 antibody (Matrix Metalloproteinase 2 (MMP2)). B. Western blot of MMP-2 antibody on recombinant MMP-2 proenzyme (400 ng/lane).

MMP2 Antibody (clone 4D1E2) LS-C169152
Mouse Monoclonal [clone 4D1E2] (IgG1) to Human MMP2
Human
ELISA, WB
Unconjugated
100µg 1mg/ml  $365.00
Western blot using MMP2 monoclonal antibody against human MMP2 recombinant protein. (Expected MW is 42.8 kDa)
Western blot using MMP2 mouse monoclonal antibody against A431 (1) cell lysate.

MMP2 Antibody LS-C746891
Rabbit Polyclonal (IgG) to Human MMP2
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
50µl  $235.00; 100µl  $295.00; 200µl  $385.00
Immunohistochemistry of paraffin-embedded human lung cancer using MMP2 Antibody at dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human breast cancer using MMP2 Antibody at dilution of 1:100 (40x lens).

MMP2 Antibody LS-C8714
Mouse Monoclonal (IgG1,k) to Human MMP2
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100µg  $635.00

MMP2 Antibody (C-Terminus) LS-C31756
Rabbit Polyclonal (IgG) to Human MMP2
Mouse, Dog, Guinea pig, Sheep, Bovine, Rat, Pig, Horse, Human, Monkey
WB
Unconjugated
100µl 0.5mg/ml  $335.00

MMP2 Antibody (clone MMP2/2C1) LS-C2814
Mouse Monoclonal [clone MMP2/2C1] (IgG1,k) to Human MMP2
Mouse, Rat, Human
ELISA, IHC, IHC-Fr, IP, WB
Unconjugated
100µl 0.76mg/ml  $335.00
1: Human Recombinant MMP-2 2: Schwann Cell Culture Medium electroblot to nitrocellulose slot blot immunolabeling 1?Ab: Matrix Metalloproteinase-2 antibody (MMP-2) [MMP2/2C1] 2?Ab: anti-mouse-biotin Detection: avidin-HRP Chromagen: DAB/H202.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

MMP2 Antibody LS-C8721
Rabbit Polyclonal (IgG) to Human MMP2
Mouse, Bovine, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µg  $665.00

MMP2 Antibody (aa30-40, clone CA-4001 or CA719E3C, Azide-free) LS-C88241
Mouse Monoclonal [clone CA-4001 or CA719E3C] (IgG1) to Human MMP2
Xenopus, Chicken, Zebrafish, Pig, Bat, Sheep, Bovine, Mouse, Dog, Rat, Hamster, Human
WB
Unconjugated, Azide-free
100µl 1mg/ml  $710.00; 200µl 1mg/ml  $1,155.00

MMP2 Antibody LS-C417149
Rabbit Polyclonal to Human MMP2
Mouse, Rat, Human
WB
Unconjugated
100µg  $305.00

MMP2 Antibody (aa30-40, clone CA-4001 or CA719E3C) LS-C88239
Mouse Monoclonal [clone CA-4001 or CA719E3C] (IgG1) to Human MMP2
Xenopus, Chicken, Zebrafish, Pig, Bat, Sheep, Bovine, Mouse, Dog, Rat, Hamster, Human
WB
Unconjugated
100µl 200µg/ml  $315.00; 500µl 200µg/ml  $650.00; 1ml 200µg/ml  $1,065.00

MMP2 Antibody (aa30-40, clone CA-4001 or CA719E3C, Biotin) LS-C88240
Mouse Monoclonal [clone CA-4001 or CA719E3C] (IgG1) to Human MMP2
Xenopus, Chicken, Zebrafish, Pig, Bat, Sheep, Bovine, Mouse, Dog, Rat, Hamster, Human
WB
Biotin Conjugated
100µl 200µg/ml  $365.00; 500µl 200µg/ml  $845.00; 1ml 200µg/ml  $1,335.00

MMP2 Antibody LS-C314391
Rabbit Polyclonal to Pig MMP2
Pig
WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $560.00
Western blot Image

MMP2 Antibody LS-C72181
Mouse Monoclonal (IgG1,k) to Human MMP2
Mouse, Rat, Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100µl  $590.00

MMP2 Antibody (APMA-Activated) LS-C8720
Mouse Monoclonal (IgG1) to Human MMP2
Human
IHC, IHC-Fr, IHC-P
Unconjugated
500µl  $815.00

MMP2 Antibody (clone VB3, Biotin) LS-C88484
Mouse Monoclonal [clone VB3] (IgG1,k) to Human MMP2
Human
IF, IP, WB
Biotin Conjugated
100µl 200µg/ml  $365.00; 500µl 200µg/ml  $845.00; 1ml 200µg/ml  $1,350.00

MMP2 Antibody (C-Terminus) LS-C32769
Rabbit Polyclonal to Human MMP2
Mouse, Rat, Human
ELISA, IP, WB
Unconjugated
50µg  $345.00

MMP2 Antibody LS-C137287
Rabbit Polyclonal (IgG) to Human MMP2
Human
IHC, WB
Unconjugated
100µl  $275.00
Immunohistochemistry Image
Western blot Image

IHC-plus™ MMP2 Antibody LS-B15998
Rabbit Polyclonal (IgG) to Mouse MMP2
Mouse, Rat, Human
IHC
Unconjugated
60µl 0.82mg/ml  $425.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE)

MMP2 Antibody LS-C488316
Rabbit Polyclonal to Mouse MMP2
Mouse
IP, WB
Unconjugated
50µl  $255.00; 100µl  $305.00; 200µl  $355.00

MMP2 Antibody LS-C8716
Rabbit Polyclonal to Human MMP2
Human
IP, WB
Unconjugated
500µl  $465.00
Showing 1-25 of 193 results

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PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).