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Catalog Number Size Price
LS-B2641-50 50 µg (1 mg/ml) $485 
MMP2 Antibody - Anti-MMP2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

PathPlus™ Monoclonal Mouse anti‑Human MMP2 Antibody (aa468‑483, IHC, WB) LS‑B2641

PathPlus™ Monoclonal Mouse anti‑Human MMP2 Antibody (aa468‑483, IHC, WB) LS‑B2641

Note: This antibody replaces LS-C8717
Antibody:
MMP2 Mouse anti-Human Monoclonal (aa468-483) Antibody
Application:
IHC, IHC-P, IHC-Fr, WB, ELISA
Reactivity:
Human, Pig
Format:
Unconjugated, Unmodified
Price
Catalog Number
$485
LS-B2641-50
Toll Free North America
206-374-1102
For Research Use Only

Overview

Antibody:
MMP2 Mouse anti-Human Monoclonal (aa468-483) Antibody
Application:
IHC, IHC-P, IHC-Fr, WB, ELISA
Reactivity:
Human, Pig
Format:
Unconjugated, Unmodified

Specifications

Description
MMP2 (matrix metalloproteinase-2, gelatinase A, CLG4) is an enzyme that functions in extracellular matrix breakdown and inflammation during embryogenesis, reproduction, tissue remodeling, arthritis, chronic airway diseases and metastasis. It plays an important role in inflammation and neovascularization. MMP2 activated by HIV-infected macrophages converts SDF-1 chemokine into a neurotoxic protein that induces neuronal death and inflammation, characterizing HIV-1 dementia. Mutations in MMP2 are correlated with arthritis, osteolysis and Torg-Winchester syndrome. In immunohistochemistry, MMP2 has cytoplasmic positivity in respiratory epithelia, placental tissue and endothelial and stromal cells in many tissues throughout the body. References: Nat. Genet. 28 (3): 261–5, PMID: 11431697; Biochimica et Biophysica Acta. 1705 (2): 69–89, PMID: 15588763; Cardiovascular Research. 2006. 69(3):562–573,DOI: 10.1016/j.cardiores.2005.12.002; Nat Neurosci. 2003 Oct;6(10):1064-71, PMID: 14502291
Target
Human MMP2
Synonyms
MMP2 | 72 kd type iv collagenase | 72 kDa gelatinase | 72 kd gelatinase | 72 kDa type IV collagenase | CLG4A | CLG4 | GelA | Gelatinase A | Matrix metalloproteinase-2 | MMP-2 | MONA | Neutrophil gelatinase | TBE-1 | Tbe-1 metalloprotease | Matrix metalloproteinase-II | MMP-II
Host
Mouse
Reactivity
Human, Pig (tested or 100% immunogen sequence identity)
Clonality
IgG1,k Monoclonal
Conjugations
Unconjugated
Purification
Purified
Modifications
Unmodified
Immunogen
Synthetic oligopeptide corresponding to aa residues 468-483 (VTPRDKPMGPLLVATF) of human MMP-2. Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Pig (100%); Marmoset, Mouse, Rat, Sheep, Hamster, Elephant, Panda, Dog, Rabbit, Horse (94%); Bovine (88%); Chicken (81%).
Epitope
aa468-483
Specificity
Recognizes the precursor and active forms of human MMP-2. Species cross-reactivity: mouse, rat, rabbit, porcine, bovine and equine MMP-2, but not with human MMP-1, 3, 9 and 13.
Applications
  • IHC
  • IHC - Paraffin (10 µg/ml)
  • IHC - Frozen (0.9 µg/ml)
  • Western blot (1 - 5 µg/ml)
  • ELISA
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Immunohistochemistry: LS-B2641 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B2641 was determined to be 10 ug/ml.
Presentation
0.1 M PBS, pH 7.0, 2% BSA (protease free).
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About MMP2
P08253 NM_004530 NP_004521.1

Validation

MMP2 Antibody - Anti-MMP2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-MMP2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-MMP2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

LSBio Ratings

PathPlus™ MMP2 Antibody (aa468-483) for IHC, WB/Western, ELISA LS-B2641 has an LSBio Rating of
Laboratory Validation Score (5)

Publications (0)

Customer Reviews (0)


Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 5/19/2024