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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MAPK8 / JNK1

mitogen-activated protein kinase 8

Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation. Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy. Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons. In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone. Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH.JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta-2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms.

Gene Name: mitogen-activated protein kinase 8
Family/Subfamily: Protein Kinase , MAPK
Synonyms: MAPK8, JNK, JNK1, JNK1A2, JNK-46, MAP kinase 8, PRKM8, SAPK1, SAPK1c, MAPK 8, C-Jun N-terminal kinase 1, JNK21B1/2, JUN N-terminal kinase
Target Sequences: NM_139049 NP_620637.1 P45983

Viewing 1-25 of 180 items
MAPK8 / JNK1 Antibody - Anti-MAPK8 / JNK1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Select
Mouse Monoclonal [clone 3H2] (IgG2a,k) to Human MAPK8 / JNK1
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg   $495.00
MAPK8 / JNK1 Antibody - Anti-MAPK8 / JNK1 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 2F3] (IgG2a,k) to Human MAPK8 / JNK1
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg   $495.00
MAPK8 / JNK1 Antibody - Anti-MAPK8 / JNK1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal to Human MAPK8 / JNK1
Chicken, Rabbit, Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50µg   $425.00
MAPK8 / JNK1 Antibody - Anti-MAPK8 / JNK1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 1A2] (IgG2a,k) to Human MAPK8 / JNK1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
MAPK8 / JNK1 Antibody - Anti-MAPK8 / JNK1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 4H6] (IgG2a,k) to Human MAPK8 / JNK1
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg   $495.00
MAPK8 / JNK1 Antibody - Anti-MAPK8 / JNK1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 4H5] (IgG2b,k) to Human MAPK8 / JNK1
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg   $495.00
MAPK8 / JNK1 Antibody - Anti-MAPK8 / JNK1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 1E1] (IgG2a,k) to Human MAPK8 / JNK1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
MAPK8 / JNK1 Antibody - Anti-MAPK8 / JNK1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 1E2] (IgG2b,k) to Human MAPK8 / JNK1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
MAPK8 / JNK1 Antibody - Anti-MAPK8 / JNK1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Mouse Monoclonal [clone 3B12] (IgG1,k) to Human MAPK8 / JNK1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   $495.00
Select
Rabbit Polyclonal to Human MAPK8 / JNK1
Xenopus, Chicken, Zebrafish, Drosophila, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Rat, Hamster, Human, Monkey
ELISA, WB
Unconjugated
50µg   $405.00
Select
Rabbit Polyclonal to Human MAPK8 / JNK1
Mouse, Rat, Human
ICC, IHC, IP, WB
Unconjugated
100µg   200µl   $455.00
MAPK8 / JNK1 Antibody - Western blot using MAPK8 monoclonal antibody against human MAPK8 (AA: 227-380) recombinant protein. (Expected MW is 43.4 kDa)
Select
Mouse Monoclonal [clone 1E5] (IgG1) to Human MAPK8 / JNK1
Human
ELISA, Flo, WB
Unconjugated
100µg   1mg/ml   $365.00
MAPK8 / JNK1 Antibody
Select
Rabbit Polyclonal (IgG) to Human MAPK8 / JNK1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   $275.00
MAPK8 / JNK1 Antibody - Western blot of MAPK8 / JNK1 / JNK antibody.
Select
Rabbit Polyclonal to Human MAPK8 / JNK1
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
30µg   $245.00; 100µg   200µl   $385.00
MAPK8 / JNK1 Antibody - Immunofluorescence analysis of NIH-3T3 cells using MAPK8/MAPK9/MAPK10 antibody.
Select
Rabbit Monoclonal to Human MAPK8 / JNK1
Zebrafish, Rat, Mouse, Dog, Bovine, Human, Monkey
IF, IP, WB
Unconjugated
50µl   $295.00; 100µl   $385.00; 200µl   $560.00
Select
Rabbit Polyclonal (IgG) to Human MAPK8 / JNK1
Mouse, Rat, Human
IHC, WB
Unconjugated
50µg   $435.00
Select
Sheep Polyclonal
ELISA, IP, WB
Unconjugated
250µg   $375.00
Select
Rabbit Polyclonal (IgG) to Human MAPK8 / JNK1
Chicken, Drosophila, Mouse, Rat, Human, C. elegans
IP, WB
Unconjugated
200µg   $605.00
MAPK8 / JNK1 Antibody
Select
Rabbit Polyclonal (IgG) to Human MAPK8 / JNK1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
MAPK8 / JNK1 Antibody
Select
Rabbit Polyclonal (IgG) to Human MAPK8 / JNK1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
MAPK8 / JNK1 Antibody
Select
Rabbit Polyclonal (IgG) to Human MAPK8 / JNK1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
MAPK8 / JNK1 Antibody - Immunohistochemistry of paraffin-embedded human prostate cancer using MAPK8 Antibody at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human MAPK8 / JNK1
Mouse, Human
ELISA, IF, IHC, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
MAPK8 / JNK1 Antibody - IHC of paraffin-embedded Carcinoma of Human prostate tissue using anti-JNK1 mouse monoclonal antibody.
Select
Mouse Monoclonal [clone OTI2C6] (IgG1) to Human MAPK8 / JNK1
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   0.49mg/ml   $345.00
Select
Rabbit Polyclonal to C. elegans MAPK8 / JNK1
C. elegans
IP, WB
Unconjugated
100µl   $530.00
MAPK8 / JNK1 Antibody
Select
Rabbit Polyclonal (IgG) to Human MAPK8 / JNK1
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00

Viewing 1-25 of 180 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).