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MAP2K4 / MKK4

mitogen-activated protein kinase kinase 4

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.

Gene Name: mitogen-activated protein kinase kinase 4
Family/Subfamily: Protein Kinase , MAP2K
Synonyms: MAP2K4, JNK activating kinase 1, JNK-activated kinase 1, JNK-activating kinase 1, MAPK/ERK kinase 4, MAPKK4, JNKK1, PRKMK4, SAPKK1, SEK1, MEK4, MKK4, SAPK/ERK kinase 1, SERK1, JNKK, MAP kinase kinase 4, MAPKK 4, MEK 4, SAPK kinase 1, SAPKK-1, SKK1
Target Sequences: NM_003010 NP_003001.1 P45985

☰ Filters
Antibodies (133)
Proteins (8)
ELISA Kits (3)
Cell-Based (1)
Cell-Based Phosphorylation (2)
Over-Expression Lysate (2)
Primary (133)
Recombinant (6)
MAP2K4 / MKK4 (144)
Human (125)
Mouse (70)
Rat (54)
Bat (4)
Bovine (9)
Chimpanzee (3)
Dog (1)
Gibbon (3)
Guinea pig (4)
Horse (4)
Monkey (6)
Pig (4)
Rabbit (4)
Sheep (1)
Zebrafish (5)
IHC (72)
IHC-P (20)
WB (103)
Flo (6)
DB (7)
ELISA (58)
ICC (5)
IF (25)
IP (12)
Peptide-ELISA (8)
rabbit (117)
mouse (16)
Product Group
IHCPlus (1)
IgG (85)
IgG1 (5)
IgG2a (4)
IgG2b (4)
IgM (2)
monoclonal mc (15)
polyclonal pc (118)
2D10D8, 4G11 B2 (1)
5H4 (2)
OTI1D6 (2)
OTI2D5 (2)
OTI2E4 (2)
OTI4B4 (2)
OTI8A8 (2)
96-Well Microplate (3)
AP Conjugated (9)
APC (1)
APC Conjugated (5)
Azide-free (4)
Biotin Conjugated (8)
Carrier-free (5)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (8)
HRP Conjugated (8)
PE Conjugated (5)
Preservative Free (1)
Unconjugated (88)
pThr261 (11)
pSer257 (10)
Ser257 (9)
pSer80 (9)
aa137-394 (8)
aa259-287 (8)
Thr261 (7)
200-280 aa (4)
aa2-397 (4)
aa222-271 (4)
20-100 aa (2)
Internal (2)
pSer257/Thr261 (2)
290-370 aa, C-terminal (1)
C-Terminus (1)
Gln253 (1)
Glu74 (1)
Lys350 (1)
N-Terminus (1)
Val255 (1)
aa223-272 (1)
aa227-276 (1)
aa316-365 (1)
aa349-399 (1)
aa360-378 (1)
aa50-100 (1)
p261 (1)
p80 (1)
pSer257/pThr261 (1)
No (144)
Adherent Cell Cultures (3)
GST (1)
GST, N-terminus (1)
His-GST (2)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (5)
Mouse (2)
293T Cells (1)
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Wheat Germ Extract (2)
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Low endotoxin level (1)
MAP2K4 / MKK4 Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using SEK1/MKK4/JNKK1 (Phospho-Ser257) Antibody. The picture on the right is blocked with the phospho peptide.
Select
MAP2K4 / MKK4 Rabbit anti-Human Polyclonal (pSer257) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$328; 100 µl/$388
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded breast tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
MAP2K4 / MKK4 Mouse anti-Human Monoclonal (OTI2E4) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded breast tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
MAP2K4 / MKK4 Mouse anti-Human Monoclonal (Carrier-free) (OTI2E4) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded muscle tissues using MAP2K4 mouse monoclonal antibody with DAB staining.
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MAP2K4 / MKK4 Mouse anti-Human Monoclonal (5H4) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$436
MAP2K4 / MKK4 Antibody
Select
MAP2K4 / MKK4 Mouse anti-Human Monoclonal (2D10D8, 4G11 B2) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$367
Select
MAP2K4 / MKK4 Rabbit anti-Human Polyclonal (pSer257/Thr261) Antibody
Human
ELISA, WB
Unconjugated
100 µl/$637
MAP2K4 / MKK4 Antibody - IHC of p-SEK1/MKK4 (S80) pAb in paraffin-embedded human breast carcinoma tissue.
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MAP2K4 / MKK4 Rabbit anti-Human Polyclonal (pSer80) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$404
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded breast tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
MAP2K4 / MKK4 Mouse anti-Human Monoclonal (OTI4B4) Antibody
Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$434
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded breast tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
MAP2K4 / MKK4 Mouse anti-Human Monoclonal (Carrier-free) (OTI4B4) Antibody
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
MAP2K4 / MKK4 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MAP2K4 / MKK4 Rabbit anti-Human Polyclonal (aa349-399) Antibody
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$485
MAP2K4 / MKK4 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of kidney tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
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MAP2K4 / MKK4 Mouse anti-Human Monoclonal (OTI8A8) Antibody
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K4 / MKK4 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of kidney tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
MAP2K4 / MKK4 Mouse anti-Human Monoclonal (Carrier-free) (OTI8A8) Antibody
Dog, Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
MAP2K4 / MKK4 Mouse anti-Human Monoclonal (OTI1D6) Antibody
Human
IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$434
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
MAP2K4 / MKK4 Mouse anti-Human Monoclonal (Carrier-free) (OTI1D6) Antibody
Human
IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
MAP2K4 / MKK4 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded muscle tissues with DAB staining using MEK-4 Monoclonal Antibody.
Select
MAP2K4 / MKK4 Mouse anti-Human Monoclonal Antibody
Human
ELISA, Flo, IHC, WB
Unconjugated
100 µl/$393
MAP2K4 / MKK4 Antibody - Immunohistochemical analysis of MKK4 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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MAP2K4 / MKK4 Rabbit anti-Human Polyclonal (Internal) Antibody
Zebrafish, Rat, Mouse, Bovine, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
MAP2K4 / MKK4 Antibody - Immunohistochemical analysis of MKK4 (pT261) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
MAP2K4 / MKK4 Rabbit anti-Human Polyclonal (pThr261) Antibody
Zebrafish, Rat, Mouse, Bovine, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$315
MAP2K4 / MKK4 Antibody - Immunohistochemical analysis of MKK4 (pS80) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
MAP2K4 / MKK4 Rabbit anti-Human Polyclonal (pSer80) Antibody
Zebrafish, Rat, Mouse, Bovine, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$315
MAP2K4 / MKK4 Antibody - Immunohistochemical analysis of MKK4 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Select
MAP2K4 / MKK4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
MAP2K4 / MKK4 Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
MAP2K4 / MKK4 Mouse anti-Human Monoclonal (OTI2D5) Antibody
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MAP2K4 / MKK4 Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
MAP2K4 / MKK4 Mouse anti-Human Monoclonal (Carrier-free) (OTI2D5) Antibody
Human
IF, IHC, IP, WB
Unconjugated, Carrier-free
100 µg/$511
MAP2K4 / MKK4 Antibody - Western blot of SEK1 antibody
Select
MAP2K4 / MKK4 Rabbit anti-Human Polyclonal (290-370 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µl/$289; 100 µl/$319; 200 µl/$389
MAP2K4 / MKK4 Antibody - SEK1 Antibody in Immunohistochemistry (IHC)
Select
MAP2K4 / MKK4 Mouse anti-Human Monoclonal (5H4) Antibody
Human
Flo, IHC, WB
Unconjugated
100 µl/$484
MAP2K4 / MKK4 Antibody - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue.
Select
MAP2K4 / MKK4 Rabbit anti-Human Polyclonal (pSer80) Antibody
IF, IHC, WB
Unconjugated
50 µl/$316; 100 µl/$391; 200 µl/$499
MAP2K4 / MKK4 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using MAP2K4 Antibody at dilution of 1:100
Select
MAP2K4 / MKK4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
Viewing 1-25 of 144 product results



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).