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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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MAP2K4 / MKK4

mitogen-activated protein kinase kinase 4

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.

Gene Name: mitogen-activated protein kinase kinase 4
Family/Subfamily: Protein Kinase , MAP2K
Synonyms: MAP2K4, JNK activating kinase 1, JNK-activated kinase 1, JNK-activating kinase 1, MAPK/ERK kinase 4, MAPKK4, JNKK1, PRKMK4, SAPKK1, SEK1, MEK4, MKK4, SAPK/ERK kinase 1, SERK1, JNKK, MAP kinase kinase 4, MAPKK 4, MEK 4, SAPK kinase 1, SAPKK-1, SKK1
Target Sequences: NM_003010 NP_003001.1 P45985

Viewing 1-25 of 142 items
MAP2K4 / MKK4 Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human MAP2K4 / MKK4
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50µl   1mg/ml   $425.00
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded breast tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI2E4] (IgG2b) to Human MAP2K4 / MKK4
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   1.16mg/ml   $345.00
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded breast tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI2E4] (IgG2b) to Human MAP2K4 / MKK4
Human
IF, IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded muscle tissues using MAP2K4 mouse monoclonal antibody with DAB staining.
Select
Mouse Monoclonal [clone 5H4] (IgG1) to Human MAP2K4 / MKK4
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100µl   $365.00
MAP2K4 / MKK4 Antibody
Select
Mouse Monoclonal [clone 2D10D8, 4G11 B2] (IgM) to Human MAP2K4 / MKK4
Human
ELISA, IHC, WB
Unconjugated
100µg   1mg/ml   $315.00
Select
Rabbit Polyclonal (IgG) to Human MAP2K4 / MKK4
Human
ELISA, WB
Unconjugated
100µl   $650.00
MAP2K4 / MKK4 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of kidney tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI8A8] (IgG2b) to Human MAP2K4 / MKK4
IF, IHC, IHC-P, WB
Unconjugated
100µl   2.36mg/ml   $345.00
MAP2K4 / MKK4 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of kidney tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI8A8] (IgG2b) to Human MAP2K4 / MKK4
Dog, Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded breast tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI4B4] (IgG2a) to Human MAP2K4 / MKK4
Human
Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1.09mg/ml   $345.00
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded breast tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI4B4] (IgG2a) to Human MAP2K4 / MKK4
Human
Flo, IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI1D6] (IgG2a) to Human MAP2K4 / MKK4
Human
IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $345.00
MAP2K4 / MKK4 Antibody - IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI1D6] (IgG2a) to Human MAP2K4 / MKK4
Human
IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
MAP2K4 / MKK4 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded muscle tissues with DAB staining using MEK-4 Monoclonal Antibody.
Select
Mouse Monoclonal (IgG1) to Human MAP2K4 / MKK4
Human
ELISA, Flo, IHC, WB
Unconjugated
100µl   $345.00
MAP2K4 / MKK4 Antibody - Immunohistochemical analysis of MKK4 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human MAP2K4 / MKK4
Mouse, Human
ICC, IF, IHC, WB
Unconjugated
30µl   1mg/ml   $205.00; 100µl   1mg/ml   $245.00; 200µl   1mg/ml   $305.00
MAP2K4 / MKK4 Antibody - Immunohistochemical analysis of MKK4 (pT261) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human MAP2K4 / MKK4
Zebrafish, Rat, Mouse, Bovine, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $265.00
MAP2K4 / MKK4 Antibody - Immunohistochemical analysis of MKK4 (pS80) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human MAP2K4 / MKK4
Zebrafish, Rat, Mouse, Bovine, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $265.00
MAP2K4 / MKK4 Antibody - Immunohistochemical analysis of MKK4 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human MAP2K4 / MKK4
Zebrafish, Rat, Mouse, Bovine, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30µl   1mg/ml   $205.00; 100µl   1mg/ml   $245.00; 200µl   1mg/ml   $305.00
MAP2K4 / MKK4 Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI2D5] (IgG1) to Human MAP2K4 / MKK4
IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
MAP2K4 / MKK4 Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-MAP2K4 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI2D5] (IgG1) to Human MAP2K4 / MKK4
Human
IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
MAP2K4 / MKK4 Antibody - Western blot of SEK1 antibody
Select
Rabbit Polyclonal (IgG) to Human MAP2K4 / MKK4
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
MAP2K4 / MKK4 Antibody - SEK1 Antibody in Immunohistochemistry (IHC)
Select
Mouse Monoclonal [clone 5H4] (IgG1) to Human MAP2K4 / MKK4
Human
Flo, IHC, WB
Unconjugated
100µl   $405.00
MAP2K4 / MKK4 Antibody - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue.
Select
Rabbit Polyclonal (IgG) to Human MAP2K4 / MKK4
IF, IHC, WB
Unconjugated
50µl   $265.00; 100µl   $375.00; 200µl   $495.00
MAP2K4 / MKK4 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using MAP2K4 Antibody at dilution of 1:100
Select
Rabbit Polyclonal (IgG) to Human MAP2K4 / MKK4
Human
ELISA, IF, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
MAP2K4 / MKK4 Antibody - Mouse Map2k4 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded mouse cerebellum tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
Select
Rabbit Polyclonal to Mouse MAP2K4 / MKK4
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human MAP2K4 / MKK4
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00

Viewing 1-25 of 142 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).